Yazar "Delen, Leman Acun" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association between blood groups and COVID-19 susceptibility(2022) Erdoğan, Esra; Delen, Leman AcunCOVID-19, become one of the biggest global problems in human history since the final days of 2019. Fever, dry cough, dyspnea, myalgia and fatigue are frequently encountered among the clinical symptoms of the patients. Although COVID-19 causes mild to moderate symptoms in most infected individuals, people with comorbid illness or people over the age of 60 have a higher risk of developing severe illness as well as death. In more severe cases, the infection causes pneumonia, severe acute respiratory failure, multiple organ failure, and even death. In this study, we aimed to examine the effects of ABO and Rh blood groups on the severity of COVID-19 infection (admission to intensive care units, intubation and death) among patients hospitalized in COVID-19 pandemic wards. Of the patients who were hospitalized in COVID-19 pandemic inpatient services in Malatya Training and Research Hospital; a tertiary health care facility serving as 1040-bed situated in Eastern Turkey, 300 adult patients with known blood groups, and the patients who had applied to the hospital’s blood bank during the same dates (control group=21911) were included in the study. Intensive care unit admission and mortality rates were found to be significantly higher in B blood group as compared to other blood groups, while intubation and death rates were found to be significantly lower in O blood group when compared to other groups. When the blood groups of the population (control group=21991) and COVID-19 patients were compared, it was seen that there was no significant difference between the blood groups, and the distribution was observed to be similar to that of the population. As a result, more research is needed in order to clarify the relationship between COVID-19 and the ABO and Rh blood groups to better understand the COVID-19 infection, which has affected the whole world.Öğe Candidemia in adult intensive care units: Analysis of a 4 year process in a tertiary hospital in Turkey(2020) Erdoğan, Esra; Erdoğan, Mehmet Mustafa; Delen, Leman AcunAim: Candidemia are one of the most important causes of mortality and morbidity in inpatients, and their importance is increasingwith the increasing number of immunosuppressive patients and the widespread use of invasive procedures and broad spectrumantibiotics in recent years. In our study, we aimed to identify Candida species isolated from blood cultures and to determine theantifungal susceptibility rates of adult patients who were hospitalized in Malatya Education and Research Hospital Intensive CareUnits between July 2015 and July 2019, and had Candida growth in at least one of their blood cultures.Materials and Methods: The blood cultures isolated from adult intensive care units patients and sent to the Microbiology Laboratoryof our hospital over the four years, were examined retrospectively. Species distribution and antifungal susceptibility were determinedusing VITEK 2 Compact System (BioMerieux, France).Results: Of the 123 clinical samples, 59 (48%) were C. albicans, 21 (17.1%) were C. parapsilosis, 18 (14.6%) were C. tropicalis, 12(9.8%) were C. glabrata, 5 (4.1%) were C. kefyr, 2 (1.6%) were C. krusei, 2 (1.6%) were C. lipoliytica, 2 (1.6%) were C. lusitaniae, 1 (0.8%)was C. dubliniensis and 1 (0.8%) was C. pelliculosa. 96.5% of C. glabrata strains were found to be susceptible to amphotericin-B,93.1% to fluconazole, 98.3% to voriconazole, 93.5% to caspofungin, 91.4% to micafungin and 96.7% to flucytosine. 98.1% of nonalbicansCandida (NAC) strains were found to be susceptible to amphotericin-B, 74.6% to fluconazole, 90.7% to voriconazole, 78.4%to caspofungin, 80% to micafungin and 100% to flucytosine.Conclusion: The highest resistance to antifungals was found in C. glabrata and the highest susceptibility was observed in C. tropicalis.In order to develop effective and accurate infection control strategies and reduce mortality and morbidity, it is important to know thedistribution and susceptibility of infectious agents, especially in critical patients in intensive care units.Öğe Comparison of nutritional risk status assessment tools in predicting 30-day survival in critically ill COVID-19 pneumonia patients(K Faisal Spec Hosp Res Centre, 2022) Kasapoglu, Umut Sabri; Gok, Abdullah; Delen, Leman Acun; Ozer, Ayse BelinBACKGROUND: Few clinical studies have addressed nutritional risk assessment in patients with COVID-19 pneumonia admitted to the intensive care unit (ICU). OBJECTIVES: Assess the nutritional risk status of the critically ill COVID-19 pneumonia patients admitted to the ICU, and compare the nutritional risk screening tools. DESIGN: Medical record review SETTINGS: Tertiary critical care unit PATIENTS AND METHODS: We included adult (age >18 years) PCR-confirmed critically ill COVID-19 pneumonia cases admitted to the ICU between August 2020 and September 2021. Scoring systems were used to assess COVID-19 severity and nutritional status (mNUTRIC: modified Nutrition Risk in Critically Ill, NRS2002: Nutritional Risk Screening 2002). The 30-day mortality prediction performance of nutritional scores and survival comparisons between clinical and demographic factors were assessed. MAIN OUTCOME MEASURES: Compare the nutrition risk tools SAMPLE SIZE: 281 patients with a mean (SD) age of 64.3 (13.3) years; 143 (50.8%) were 65 years and older. RESULTS: The mean mNUTRIC score of the cases was 3.81 (1.66) and the mean NRS-2002 score was 3.21 (0.84.), and 101 (35.9%) were at high risk of malnutrition according to the mNUTRIC score and 229 (81.4%) according to the NRS 2002 score. In cases at high risk of malnutrition by the mNUTRIC score there was a greater need for invasive mechanical ventilation, vasopressors, and renal replacement therapy (P<.001 for all comparisons). The mNUTRIC score was superior to the NRS-2002 score in estimating 30-day mortality. In patients who died within 30 days, the mNUTRIC score and NRS-2002 score on the day of hospitalization were significantly higher (P<.001), and the proportion of patients with NRS2002 score >= 3 and mNUTRIC score >= 5 was significantly higher in the non-surviving group (P<.001). In addition, patients with a high risk of malnutrition had a shorter survival time. The mNUTRIC score was an independent and important prognostic factor for 30-day mortality, and patients with an mNUTRIC score >= 5 had a 6.26-fold risk for 30-day mortality in the multivariate Cox regression. CONCLUSION: One third of critical COVID-19 pneumonia cases hospitalized in the ICU due to acute respiratory failure have a high risk of malnutrition, and a high mNUTRIC score is associated with increased mortality. LIMITATIONS: Single center retrospective study.Öğe Differential diagnosis of COVID-19 pneumonia from acute heart failure in pandemic: Importance of radiological and laboratory findings(Turkish Assoc Tuberculosis & Thorax, 2021) Kasapogu, Umut Sabri; Gok, Abdullah; Delen, Leman Acun; Sayan, Hasan; Kacmaz, Osman; Cagasar, Ozlem; Karaca, RukanIntroduction: COVID-19 pneumonia typically presents with high fever, cough, and shortness of breath and on thorax computed tomography (CT) peripheral ground glass opacities help the diagnosis. Although typical imaging findings for COVID-19 pneumonia are specified in thorax CT, these findings can confused with other diseases. The aim of this study is to investigate the roles of radiological imaging and laboratory findings in the differential diagnosis of COVID-19 pneumonia and acute heart failure (AHF). Materials and Methods: In the present study, 74 patients who admitted to the emergency department with respiratory distress during the pandemic period and received a diagnosis of COVID-19 pneumonia and AHF were included. Laboratory data and radiological findings of the patients, at the time of admission, were evaluated. Results: On admission, there was no difference in age, gender between two groups. However, COVID-19 exposure history was found significantly higher in COVID-19 pneumonia patients group (p< 0.001). Fever, cough, and fatigue were found significantly higher in the COVID-19 pneumonia patients group (p< 0.001). There was difference of lesions distribution between the two groups, centrally distributed lesions were found significantly higher in acute heart failure patients (p< 0.001). Pleural effusion and cardiomegaly were found significantly higher in AHF patients (p< 0.001, p< 0.001). Counts of the white blood cells and lymphocytes were found significantly lower in COVID-19 pneumonia patients 0.003, p= 0.009). COVID-19 pneumonia patients had significantly higher levels of CRP ferritin, LDH and CK compared with AHF patients (p< 0.001, p< 0.001, p= 0.002, p= 0.013). However the level of NT-proBNP was found significantly higher in the AHF patients group (p< 0.001). Conclusion: We believe that laboratory data and thorax CT findings can provide beneficial clinical information in differentiating COVID-19 pneumonia from AHF during the pandemic.Öğe EFFECTS OF HYDROXYCHLOROQUINE PLUS FAVIPIRAVIR TREATMENT ON THE CLINICAL COURSE AND BIOMARKERS IN HOSPITALIZED COVID-19 PATIENTS WITH PNEUMONIA(Sestre Milosrdnice Univ Hospital, 2022) Delen, Leman Acun; Gok, Abdullah; Kasapoglu, Umut Sabri; Cagasar, Ozlem; Gok, Zarife; Berber, Nurcan; Derya, SerdarBackground: The novel coronavirus disease 2019 (COVID-19) has a broad spectrum of clin-ical manifestations, the most common serious clinical manifestation of the coronavirus infection being pneumo-nia. Unfortunately, the optimal treatment approach is still uncertain. However, many studies have been conducted on the effectiveness of several medications in the treatment of COVID-19 infection. The aim of this study was to evaluate the effectiveness of the hydroxychloroquine (HCQ) + favipiravir (FAV) treatment regimen and HCQ alone by comparing the patient's clinical response and laboratory results on the fifth day of treatment in patients hospitalized due to COVID-19 infection.Patients and methods: This retrospective cohort study was conducted in Malatya Training and Research Hospital between March 2020 and July 2020. The study included 69 patients with confirmed COVID-19 with pneumonia. The patients were divided into 2 groups, those receiving HCQ alone and those receiving the HCQ + FAV combination.Results: A total of 69 patients were included in the study, and the mean age was 60.09 +/- 15.56 years. A statisti-cally significant decrease was observed in C-reactive protein (CRP) levels, at the end of the fifth day, in patients who received HCQ + FAV treatment (p=0.002), whereas there was no decrease in CRP levels in patients who received HCQ treatment alone. In addition, an increase in lymphocyte count and a better fever response was observed at the end of the fifth day in patients who received HCQ + FAV (p=0.008). However, there was no statistical difference between both treatment regimens in terms of hospital stay and treatment results (p=0.008, p=0.744, p=0.517).Conclusion: Although the combination of HCQ + FAV treatment was observed to be effective on CRP levels and fever response in patients with COVID-19 pneumonia, there was no difference in terms of hospital stay and discharge.Öğe The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction(Aepress Sro, 2022) Delen, Leman Acun; Disli, Zeliha Korkmaz; Tas, Hakan G.; Kuyrukluyildiz, Ufuk; Yazici, Gulce N.; Suleyman, Bahadir; Kuzucu, MehmetPropofol may cause an increase in reactive oxygen species in the body. In this study, we tested the effect of antioxidant thiamine pyrophosphate (TPP) on propofol-induced liver damage. The eighteen rats were split into three groups: HG, healthy; PP, propofol-treated (50 mg/kg) and PT, treated with propofol (50 mg/kg) and TPP (25 mg/kg). Total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) levels were tested together with aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and malondialdehyde (MDA). Histopathological examination of the tissues was performed. We have found that levels of MDA, TOS, ALT, AST, and LDH were all higher in PP group than in HG and PT groups (p < 0.05). In PP group, the TAS and tGSH levels were statistically substantially lower. The PT for oxidants levels showed a statistically significant reduction. In PT group, the levels of antioxidants were found to be considerably higher. The epitheliums, glands, and vascular structures of the PTs were histologically close to normal. By boosting antioxidants, TPP may help to reduce propofol-induced liver damage.Öğe Evaluation of Code Blue activations in Covid 19 Patients andnon-COVID-19 patients: A retrospective research review(2022) Delen, Leman Acun; Dişli, Zeliha KorkmazWe aimed to contribute to increase the efficiency of the Cardiopulmonary Resusitation (CPR) interventions by comparing the code blue applications activated for patients with and without COVID 19 during the pandemic process. The code blue registration forms who were diagnosed with and without COVID-19 and underwent resuscitation, between March 15-November 30, 2020 were examined retrospectively through the hospital information processing system. Demographic data, time of code blue activation, COVID-19 status, call accuracy, initial heart rhythm, respiratory arrest, survival in the first 24 hours, 30-day survival, discharge, time to reach unit. CPR durations were recorded. 79% of patients with code blue were covid-19. İnitial asystolic rhythm was present 16.7%, VF arrest was present in 34.8% and respiratory arrest was present in 71.7% patients and 53.6% of the patients died in the first 24 hours. The average time the team reaches the unit was aproximately 3 minutes, and the mean CPR duration was apoximately 30 minute. The rate initial asystolic rhythm was found higher in COVID- patients . The rate being declared exitus was higher in COVID-19 patients. The time to reach the place of activation and the duration of CPR were found higher in COVID-19 patients. The time to reach the place was found to be delayed for about 1 minute in our study. To develop strategies for minimizing the time between wearing the protective equipment properly and the response to the blue code without delay should be our first goal for the success of resuscitation.Öğe Experience and opinions of healthcare professionals on COVID-19 and inactive COVID-19 Vaccine (Coronavac, developed by sinovac of china)(2022) Tetik, Burcu Kayhan; Tekin, Çiğdem; Delen, Leman Acun; Tekinemre, Işılay Gedik; Bayindir, YasarIt is aimed to determine the opinions and experiences of healthcare professionals about COVID-19, inactive COVID-19 vaccine and the frequency of hesitation, vaccine rejection, and vaccination status, and to analyze the reasons for vaccine rejection and the contributing factors. The research is a cross-sectional study, and the universe of the study consists of all healthcare personnel (7200 people) working in hospitals. The independent variables of the questionnaire included socio-demographic characteris- tics, descriptive questions about the COVID-19 pandemic, and the COVID-19 Fear Scale. A value of p <0.05 was considered statistically significant. We found that 26.2% (184) of the healthcare workers participating in the study were diagnosed with COVID-19. 53.7% of the participants reported that they provided health care for COVID-19 patients. When the vaccine preferences of the participants were questioned, 42.2% stated that they would prefer the Chinese CoronaVac vaccine, 30.1% Turkish vaccine, 22.4% German BioNTechPfizer vaccine, 1.7% American Moderna vaccine, 3.1% English Oxford AstraZeneca vaccine, and 0.6% the Russian Gamaleya vaccine. When the reasons for anti-vaccine attitude were questioned, 44.2% of the participants stated that they did not think the vaccine was safe. When we compared the COVID-19 Fear Scale scores according to the characteristics of the participants, we found that individuals in the 35-44 age group got higher COVID-19 Fear Scale scores than the other groups (p<0.05). When the median scores of the profession groups were compared, the median scores of nurses/midwives/paramedics were found to be higher than the other groups (p<0.05). Awareness in the population can be raised and confusion can be eliminated by healthcare professionals by speaking clearly and decisively, based on experience in previous epidemics.Öğe The Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Rats(Colegio Farmaceuticos Provincia De Buenos Aires, 2022) Disli, Zeliha Korkmaz; Delen, Leman Acun; Tas, Hakan Gokalp; Kuyrukluyildiz, Ufuk; Disli, Olcay Murat; Yazici, Gulce Naz; Coban, AbdulkadirThe metabolite of desflurane has been linked to hepatotoxicity. Carvacrol possesses antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, and spasmolytic properties, according to research. Our goal is to demonstrate that carvacrol protects rats' livers against repeated doses of desflurane. Healthy (HG), desflurane (DS), and carvacrol + desflurane treatment (CDS) groups were formed from 18 albino male Wistar rats. A single dosage of carvacrol and 6% desflurane was given for 2 h on the 0th and 8th days. In the CDS group, the ALT and AST, MDA, TOS, NF-xB, TNF-alpha IL1 beta levels were lower compared to the DS group (p < 0.001). The tGSH,TAS levels were found to be higher in the CDS group compared to the DS group (p < 0.001). It was determined that the mean degeneration level, Kupffer cell activation and PMNL infiltration were found to be lower compared to the DS group (p < 0.05).We confirmed that carvacol can be used in the treatment of desflurane-related liver injury.Öğe The Risk Factors Affecting Length of Stay and Mortality in Covid 19 Patients: Laboratory Parameters, Comorbidities, and Demographic Characteristics(Duzce Univ, Fac Medicine, 2021) Delen, Leman Acun; Erdogan, Esra; Yasar, SeymaObjective: Covid 19 can cause fatal pneumonia and serious complications. In the course of the disease the levels of different biochemical parameters increased and these parameters provide important information about the prognosis of the disease. The aim of this study was to investigate the relationship between biochemical parameters and length of stay and mortality in Covid 19 patients. Methods: In this retrospective study, a total of 767 Covid 19 patients hospitalized in our hospital were included. The demographic characteristics, length of stay, comorbid diseases and biochemical parameters of the patients were scanned from the hospital's database and patient files and recorded. Patients were grouped according to the length of stay; 1st Group: 7 days and less, 2nd Group: 8-10 days, 3rd Group: 11-13 days, and 4th Group: 14 days and more. Results: The mean CRP level was significantly higher in group 4 compared to group 1 (p = 0.002). The mean levels of LDH, PRO_BNP, and procalcitonin were significantly higher in group 4 compared to group 1 and group 2 (p <0.001, p = 0.026, p = 0.007, respectively). The mean level of fibrinogen was significantly higher in group 4 compared to group 2 (p = 0.011). Presence of DM and HT as comorbidities (p = 0.022, p = 0.006) and high levels of LDH and ferritin (p <0.001, p = 0.041) significantly increased the risk of death. Conclusions: The results of our study show that positive correlation between the levels of CRP, LDH, PCT, PROBNP, and fibrinogen the prolongation of hospitalization in Covid 19 patients and these parameters can be associated with the severity disease. These results show that increased levels of LDH and ferritin, age, prolongation of hospitalization, and the presence of HT and DM increase mortality rate and can be specific parameters in terms of prognosis.Öğe YOĞUN BAKIM ÜNİTELERİNDEN İZOLE EDİLEN PSEUDOMONAS AERUGİNOSA SUŞLARININ ANTİBİYOTİKLERE DUYARLILIKLARI(2021) Erdoğan, Mehmet Mustafa; Delen, Leman Acun; Erdoğan, EsraÖz: Pseudomonas aeruginosastrains are frequently isolated, especially from inpatient samples in intensive care units. These strains lead to infections that are difficult to treat due to antibiotic resistance, thus increasing morbidity and mortality. The aim of this study is to determine the resistance of P. aeruginosaisolates, isolated from intensive care patients of Malatya Training and Research Hospital, to various antibiotics. P. aeruginosastrains isolated from various clinical samples of patients who were followed up in intensive care units of Malatya Training and Research Hospital between July 2016 and July 2019, were included in the study. Identification and in vitro antibiotic susceptibility of the strains were determined using Vitek 2 automated system (bioMérieux, France). Of the 468 P. aeruginosastrains included in the study, 51.7% were isolated from respiratory tract samples, followed by urine samples with 31.2% and, abscess and wound samples with 9%. Colistin and norfloxacin were determined to be the most effective antibiotics for P. aeruginosastrains, while the lowest susceptibility was determined for aztreonam among the studied antibiotics. Susceptibility rates were determined to be; 76.5% for amikacin, 8.1% for aztreonam, 74.4% for gentamicin, 62.2% for imipenem, 97.1% for colistin, 57.5% for levofloxacin, 61.4% for meropenem, 57.4% for netilmisin, 89.9% for norfloxacin, 48.7% for piperacillin/tazobactam, 35.7% for piperacillin, 57.7% for cefepime, 62.7% for ceftazidime, 66% for ciprofloxacin, and 80.9% for tobramycin. In order to develop effective and accurate infection control strategies and reduce morbidity and mortality, it is important to know the distribution and susceptibility of infectious agents, especially in critical patients in intensive care units.
