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Öğe An Algorithm Recommendation to Detect Specific Pathology of the Lacrimal Sac(Lippincott Williams & Wilkins, 2022) Demirel, Soner; Firat, Murat; Firat, Ilknur Tuncer; Dikci, SeyhanWe aimed to recommend an efficient algorithm to detect the presence of specific pathologies of the lacrimal sac (LS). The charts of 296 patients who had undergone LS biopsy were reviewed retrospectively. The age, gender, history, examination and radiological findings, sac appearance, and pathology results of the patients were recorded. The power of our data to predict the presence of potential specific pathology was identified by regression analysis. After the causality evaluation of the statistical results, an algorithm was created to differentiate specific LS pathologies from chronic dacryocystitis. Our algorithm was mainly formed by deciding on radiological examination and biopsy according to the risk scoring created by the examination findings. A specific LS pathology was observed in 11(3.7%) patients. When we applied the recommended algorithm to cases with a suspicion of specific pathology and/or found to have a specific pathology, 36.4% of the patients would not require radiological examination and 29.6% of them would not require a biopsy. On the other hand, 80% of the frozen biopsies had been conducted on cases without a specific pathology. Managing the cases according to our algorithm would mean that frozen biopsy would be recommended in only 1 (12.5%) case without a specific pathology. Besides, the detection of cases with a specific pathology would not be prevented and the necessary diagnostic procedures would continue to be performed. Specific LS pathologies can be detected adequately, whereas decreasing unnecessary examinations and procedures in cases without a specific pathology by using our algorithm.Öğe Anatomical and functional results of pars plana vitrectomy+ ILM peeling+ gas endotamponade in patients with idiopathic stage 4 macular hole(2019) Dikci, Seyhan; Demirel, Soner; Tuncer Firat, Ilknur; Yilmaz, TurgutAim: To evaluate the anatomical and functional results in cases underwent 23-gauge pars plana vitrectomy (PPV) due to idiopathic stage 4 macular hole.Material and Methods: 17 eyes of 17 patients who underwent PPV due to idiopathic stage 4 macular hole between March 2013 and March 2016 at İnönü University Turgut Özal Medical Center Department of Ophthalmology were included in the study. The medical records of the patients were retrospectively reviewed. Macular hole staging was performed according to biomicroscopic examination and optical coherence tomography findings. Anatomical success was evaluated according to the condition of the macular hole after the surgery and functional success was evaluated according to the visual acuity.Results: 9 (53%) of the cases were females and 8 (47%) were males, the mean age was 66.6 ± 6.6 (55-81). PPV, internal limiting membrane (ILM) peeling and gas tamponade were applied to all cases. The mean follow-up period was 13.9±9.7 (4-30) months. ILM peeling was performed using trypan blue in three (17.6%) of the cases, brillant blue in 4 (23.5%) of the cases and membrane blue in 10 (58.8%) of the cases. Three cases (17.6%) were treated with C3F8 and 14 cases (82.3%) with SF6 gas tamponade. The mean preoperatively best-corrected visual acuity (BCVA) was 0.08±0.06 (0.03-0.2) and the mean postoperatively BCVA was 0.16±0.15 (0.03-0.5). Visual acuity did not change in two eyes (11.7%) and decreased in two eyes (11.7%). Macular hole had not closed in four patients (23.5%).Conclusion: 23 gauge PPV, ILM peeling and C3F8 or SF6 gas tamponade provides anatomical and functional success in the treatment of idiopathic stage 4 macular hole.Keywords: Internal limiting membrane; Macular hole; Pars plana vitrectomy.Öğe Anatomical and functional results of pars plana vitrectomy+ ILM peeling+ gas endotamponade in patients with idiopathic stage 4 macular hole(2019) Dikci, Seyhan; Demirel, Soner; Tuncer Fırat, İlknur; Yılmaz, TurgutAbstract: Aim: To evaluate the anatomical and functional results in cases underwent 23-gauge pars plana vitrectomy (PPV) due to idiopathic stage 4 macular hole. Material and Methods: 17 eyes of 17 patients who underwent PPV due to idiopathic stage 4 macular hole between March 2013 and March 2016 at İnönü University Turgut Özal Medical Center Department of Ophthalmology were included in the study. The medical records of the patients were retrospectively reviewed. Macular hole staging was performed according to biomicroscopic examination and optical coherence tomography findings. Anatomical success was evaluated according to the condition of the macular hole after the surgery and functional success was evaluated according to the visual acuity. Results: 9 (53%) of the cases were females and 8 (47%) were males, the mean age was 66.6 ± 6.6 (55-81). PPV, internal limiting membrane (ILM) peeling and gas tamponade were applied to all cases. The mean follow-up period was 13.9±9.7 (4-30) months. ILM peeling was performed using trypan blue in three (17.6%) of the cases, brillant blue in 4 (23.5%) of the cases and membrane blue in 10 (58.8%) of the cases. Three cases (17.6%) were treated with C3F8 and 14 cases (82.3%) with SF6 gas tamponade. The mean preoperatively best-corrected visual acuity (BCVA) was 0.08±0.06 (0.03-0.2) and the mean postoperatively BCVA was 0.16±0.15 (0.03-0.5). Visual acuity did not change in two eyes (11.7%) and decreased in two eyes (11.7%). Macular hole had not closed in four patients (23.5%). Conclusion: 23 gauge PPV, ILM peeling and C3F8 or SF6 gas tamponade provides anatomical and functional success in the treatment of idiopathic stage 4 macular hole.Öğe Apart From Surgical Procedures, Another Important Point to Note in Lacrimal Canalicular Lacerations: Traumatic Retinal Tears(Lippincott Williams & Wilkins, 2019) Demirel, Soner; Dikci, Seyhan; Firat, Penpe Gul; Genc, Oguzhan; Mutlu, KayhanBackground: To evaluate fundus examinations in terms of traumatic retinal tears or dialysis that may be related to canalicular lacerations (CLs). Materials and Methods: This retrospective study was conducted on patients with CL repair from June 1, 2009 to May 30, 2018. The authors collected the data from the patients' medical records, including their demographic details, mechanism and setting of injury, associated ocular injuries, type of stent used, setting of repairs, duration of follow-up, complications, pre- or intraoperative findings of biomicroscopic and fundus examinations, refractive errors, postoperative follow-up of fundus examination, and management. Results: Sixty patients (43 males and 17 females) were included in the study. The mean age of all the patients was 27.50 +/- 21.72 (min: 1-max: 94) years. Isolated CL was found in 38 patients. Nonisolated CL, which means with some additional pathologies, were found in 22 patients (37%, approximately 1/3). Retinal follow-up records were available in 49 patients with a mean follow-up period of 7.48 +/- 9.82 months. Retinal tears were seen in 3 patients (0.05%) with no predisposing risk factors. Two of these tears were found in the follow-up period after the traumas. Conclusion: Consequent retinal tears after canalicular lacerations were not strongly addressed in previous works. In this study, the authors aimed to view CL from a different perspective. Canalicular laceration is also an ocular trauma that may threaten vision. The authors emphasized that performing detailed fundus examinations and follow-up in all canalicular traumas is necessary.Öğe The association of outer retinal tubulation with vitreomacular adhesion and epiretinal membrane in eyes with age-related macular degeneration(2020) Dikci, Seyhan; Ulucan, Pamuk Betül; Demirel, Soner; Fırat, Penpe Gül; Yılmaz, TurgutAbstract: Aim of this study to investigate the relationship between outer retinal tubulation (ORT) and vitreomacular adhesion (VMA) or epiretinal membrane (ERM) in eyes with age-related macular degeneration (ARMD). 251 eyes of 138 (46 female, 92 male) patients were included in the study. Of those, 84 eyes were with dry type ARMD, 167 eyes were with wet type ARMD. Medical records of the cases were evaluated retrospectively. Evaluation of the vitreomacular interface (including VMA and ERM), and ORT was checked by using optical coherence tomography. VMA was observed in 26 eyes of 251 eyes and ERM in 46 of 251 eyes. In eyes with VMA, while ORT was not found in dry type ARMD, ORT was found in 5 (29.4%) of 17 eyes with wet type ARMD. In eyes with ERM, while ORT was found in one of 13 eyes (7.7%) with dry type ARMD, ORT was found in 6 (18.2%) of 33 eyes with wet type ARMD. No statistically significant difference was found between ORT presence and ERM or VMA presence in dry or wet type ARMD patients (p?0.05). Our study results suggest that, although there is no correlation between VMA and ERM with development of ORT in ARMD, further large-scale studies are required to confirm these findings and to establish a definite conclusion.Öğe The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome (vol 19, pg 166, 2019)(Bentham Science Publ Ltd, 2019) Dikci, Seyhan; Ozturk, Emrah; Firat, Penpe Gul; Yilmaz, Turgut; Taskapan, Mehmet Cagatay; Yologlu, Saim[Abstract Not Available]Öğe Bilateral retinal vasculitis in a patient with lichen planus(Consel Brasil Oftalmologia, 2016) Dikci, Seyhan; Genc, Oguzhan; Yilmaz, Turgut; Firat, Penpe GulLichen planus (LP) is an autoimmune, inflammatory disease of unknown etiology that commonly affects the skin and mucous membranes. Retinal vasculitis is a group of vision-threatening disorders, in which autoimmunity is thought to play a role in pathogenesis. We present the case of a patient who was diagnosed with retinal vasculitis and who was followed up for mucosal LP. LP has not been reported as a cause of retinal vasculitis in the literature. We believe that the retinal vasculitis in this case was related to LP because cellular immunity plays a role in the pathogenesis of both entities.Öğe Canalicular Incisional Approach for Recanalization of Punctum: A Modified Surgical Treatment for Acquired Complete Upper and Lower Punctum Occlusions as an Alternative to Bypass Methods(Lippincott Williams & Wilkins, 2020) Demirel, Soner; Ozturk, Emrah; Dikci, Seyhan; Firat, Penpe GulPurpose: To define the success of surgical technique used in the treatment of epiphora that is caused by bi-canalicular acquired complete punctum occlusion. Materials and Methods: The study is a retrospective consecutive case series, who underwent canalicular incisional approach for recanalization (CIAFOR) for acquired bi-canalicular punctum occlusions. The authors have used this technique in the cases not possible to perform a punctum dilatation and not possible to determine the punctum location exactly due to severe fibrosis. Functional and anatomical success was evaluated by the absence of epiphora and with lavage at post-operative 6th months. Results: Seven eyes of 5 patients (3 males and 2 females) were included in the study. The ages of the patients were 70, 65, 45, 64, and 70 years, respectively. Current follow-up periods vary between 6 and 23 months. Although functional and anatomical success achieved in all eyes, complication such as accessory punctum observed. Conclusions: CIAFOR seems to be a successful and simple surgical technique to treat acquired total punctum occlusion.Öğe Clinicopathological analysis of conjunctival lesions: An experience from the eastern part of Türkiye(2023) Akatlı, Ayşe Nur; Dikci, SeyhanAim: The aim of our study is to determine the clinical-pathological features of conjunc- tival lesions operated in a tertiary-care hospital in the eastern region of our country over a 10-year period. Materials and Methods: Demographic data of the patients and histopathological find- ings in the conjunctival biopsy specimens that were sent to our pathology laboratory between January 2010 and July 2020 were retrospectively analyzed. Lateralization, local- ization, distribution rates and frequency of lesions in different histopathological subgroups according to age and gender were evaluated. Results: 286 conjunctival biopsy materials from 272 patients were analyzed. The age of the patients ranged from 1 to 95, and the mean age was 50.39±23.59. One hundred and sixteen (43%) of the patients were female and 156 (57%) were male. Of the lesions, 144 (50.3%) were located in the right eye, and 142 (49.7%) were located in the left eye. In our series, the most common lesion was pterygium with a rate of 33.9%, and the second most common conjunctival lesion was nevi with a rate of 19.2%. Nevi were the most common melanocytic lesion with a rate of 93.2%. Melanocytic lesions are the most common lesions in childhood and adolescence, with a significant decrease in incidence with increasing age. Degenerative lesions were seen in all age groups, they were most common over the age of 45 (n:76, %78). In the 46-65 age groups pterygium was the most common lesion among all groups with a rate of 40.2%. Among epithelial neoplastic lesions, benign lesions, premalignant lesions, and malignant lesions were detected with a rate %2.4 %16.4, and %3.5 respectively. Most of the lesions were located in the bulbar conjunctiva (87.4%). This was followed by tarsal (5.2%), caruncle/fornix (4.9%) and limbus (2.4%) locations, respectively. Conclusion: Melanocytic lesions are more common in the first two decades, and degen- erative lesions are commonly seen after the 4th decade. In advanced ages (over 65 years), premalignant and malignant lesions are seen at a very high rate. Pterygium is accom- panied by CIN with a rate of 7% and all conjunctival lesions should be directed to the pathology laboratory for histopathological examination.Öğe Coats BenzeriRetinitis Pigmentoza(Retina-Vitreus, 2015) Demirel, Ersin Ersan; Dikci, Seyhan; Genç, Oğuzhan; Yılmaz, TurgutÖz:Retinitis pigmentoza (RP); dünya genelinde en yaygın görülen, fotoreseptör hücrelerinin ilerleyici kaybı ve retinal pigment depositleriyle karakterize kalıtsal bir grup retinal dejeneratif hastalıktır. İzole olarak da görülebilen RP birçok sendrom ile birlikte bulunabilir. RP'nin rod-kon distrofisi olarak bilinen tipik formunun yanında atipik formları da mevcuttur. Eksudatif retina dekolmanı ve kistoid maküla ödemi gibi patolojileri bulunduran Coats benzeri retinitis pigmentosa atipik retinitis pigmentosa çeşitlerinden biridir. Bu çalışmada kliniğimize yaklaşık bir yıldır karanlıkta görme güçlüğü, son üç aydır da sağ gözde gün ışığında da devam eden görme azlığı şikayeti ile başvuran ve yapılan göz muayenesi sonucunda Coats benzeri RP tanısı konulan 31 yaşındaki erkek hasta sunuldu. Nadir bir RP türü olan Coats benzeri RP hakkında son yayınlar ışığında küçük bir derleme yapmayı amaçladıkÖğe Comparison of intravitreal ranibizumab and bevacizumab treatment for retinopathy of prematurity(Consel Brasil Oftalmologia, 2016) Ceylan, Osman Melih; Dikci, Seyhan; Genc, Oguzhan; Yilmaz, Turgut[Abstract Not Available]Öğe Comparison of Nd:YAG laser (532 nm green) vs diode laser (810 nm) photocoagulation in the treatment of retinopathy of prematurity: an evaluation in terms of complications(Springer London Ltd, 2020) Dikci, Seyhan; Demirel, Soner; Firat, Penpe Gul; Yilmaz, Turgut; Ceylan, Osman Melih; Bag, Harika Gozde GozukaraPurpose To compare the anterior and posterior segment complications of diode (810 nm) laser photocoagulation (LPC) and Nd:YAG (532 nm green) LPC in the treatment of retinopathy of prematurity (ROP). Patients and methods The 84 eyes of 43 patients treated with diode LPC (group 1) and 58 eyes of 31 patients treated with Nd:YAG LPC (group 2) for ROP in our clinic were enrolled in the study. Medical records of all patients were investigated retrospectively. The patients in each group were examined in terms of birth weights, gestational weeks, stage of retinopathy, number of lasers pots, laser parameters, and anterior and posterior complications of LPC. Results The mean birth weeks of group 1 patients were postmenstrual 27.7 +/- 2.5 (23-33), while the mean birth weights were 1006.0 +/- 334.5 (540-1980) grams. The mean birth weeks of group 2 patients were postmenstrual 27.4 +/- 2.6 (23-33), while the mean birth weights were 1073.8 +/- 329.2 (480-1720) grams. The mean numbers of laser spots were 1036.0 +/- 515.2 (430-2410) in group 1 per eye, while the mean numbers of laser spots were 1085.4 +/- 526.0 (445-2530) in group 2 per eye (p >= 0.05). Additional laser application was performed in four eyes (4.8%) in group 1 and four eyes (6.9%) in group 2. Four eyes (4.8%) treated with diode LPC and one eye (1.7%) treated with Nd:YAG laser developed retinal detachment. Two eyes of a patient (3.4%) applied Nd:YAG LPC developed cataract. Conclusion Cataract may develop when Nd:YAG laser is used; however, posterior segment complications may be more likely to appear with the use of diode laser in these cases.Öğe Computed Tomography Diagnostic Abilities for Open-Globe Injuries in Pediatric Versus Adult Patients(Lippincott Williams & Wilkins, 2021) Dikci, Seyhan; Yildirim, Ismail Okan; Firat, Murat; Firat, Penpe Gul; Demirel, Soner; Yilmaz, Turgut; Tuncer, IlknurObjectives The aim of this study was to compare the role of computed tomography (CT) in the diagnosis of open-globe trauma and intraocular foreign body (IOFB) in pediatric and adult age groups. Methods Medical records of cases with open-globe trauma at Inonu University Hospital's Ophthalmology Emergency Service were retrospectively evaluated. Preoperative orbital CT images of the cases obtained at emergency services and their clinical and/or surgical findings were compared in pediatric and adult groups. Results We included 47 eyes of 47 cases aged 18 years and below (pediatric group) and 85 eyes of 82 cases over 18 years (adult group). The mean +/- SD age was 10.80 +/- 5.11 years (range, 2-18 years) in the pediatric group and 46.34 +/- 19.01 years (range, 19-82 years) in the adult group. Computed tomography images revealed 21.7% of the cases with corneal lacerations, 55.5% with scleral lacerations, and 91.6% with corneoscleral lacerations in the pediatric group, whereas the respective numbers were 48.4%, 66.6%, and 61.9% in the adult group. The detection rates of corneal penetrations and vitreous hemorrhage with CT were significantly lower in the pediatric group than in the adult group (P < 0.05). The CT scans diagnosed 66.6% of the pediatric cases and 90% of the adult cases with an IOFB. Conclusions Corneal lacerations and IOFBs can be missed, especially in the pediatric group, because the eye is smaller in adults. Pediatric patients with a history of ocular trauma should undergo an examination under general anesthesia followed by surgical exploration if necessary.Öğe Conjunctival impression cytology and tear-film changes in cases with vitamin D deficiency(Springer, 2020) Dikci, Seyhan; Akatli, Ayse Nur; Yildirim, TulayPurpose To evaluate conjunctival surface cells and tear-film functions in cases with vitamin D deficiency. Methods Thirty-six patients with serum vitamin D deficiency and 27 control subjects with normal serum vitamin D levels were included in this prospective study. The tear break-up time (TBUT), Schirmer II test, and conjunctival impression cytology tests were performed to all participants. Results The mean serum vitamin D levels were 10.5 +/- 5.0 mu l in the study group and 33.9 +/- 11.7 mu l in the control group (p < 0.001). The median TBUT scores were 11 s and 17 s and the median Schirmer II values were 7.5 mm and 12 mm in the study and the control groups, respectively (p = 0.003, p = 0.049). According to the Nelson staging system, 69.4% of the patients in the study group had grade 2 or 3 impression cytology, whereas 18.5% of the participants in the control group had grade 2 or 3 impression cytology (p < 0.001). Conclusion Our study results showed that vitamin D deficiency may lead to dry eye causing conjunctival squamous metaplasia and loss of goblet cells on the ocular surface.Öğe Correlation between intraocular pressure obtained with water drinking test versus modified diurnal tension curve measurement in pseudoexfoliation glaucoma(Springer, 2021) Firat, Penpe Gul; Dikci, Seyhan; Firat, Ilknur Tuncer; Demirel, Soner; Firat, Murat; Ozturk, Emrah; Gok, Zarife EkiciPurpose The aim of this paper was to study the correlation and agreement between the intraocular pressure (IOP) peak value and fluctuations detected with the modified diurnal tension curve (mDTC) and the water drinking test (WDT) in pseudoexfoliation glaucoma (XFG) patients. Methods This prospective observational study enrolled 42 eyes of 42 XFG patients. The IOPs were measured at 2-h intervals from 8 am to 4 pm with a Goldmann applanation tonometer by a single observer to establish the mDTC. The WDT was then performed between 4 and 5 pm on the same day and the IOP was measured 4 times at 15-min intervals after water ingestion. The IOPpeak, IOPmean, IO (min), and IOPfluctuation were measured with both the mDTC and WDT. The paired sample t test, Spearman's correlation coefficient and Bland-Altman plots were used for statistical analysis. Results The mean age of the 42 patients consisting of 24 females and 18 males was 66.9 +/- 6.8 years, and the mean central corneal thickness was 517.7 +/- 29.1 mu m. The mean values with the mDTC and WDT measurements were 15.05 +/- 2.75 mmHg and 17.17 +/- 3.25 mmHg (p <= 0.0001, r = 0.884) for IOPmean, 16.76 +/- 3.45 mmHg and 18.92 +/- 3.94 mmHg (p <= 0.0001, r=0.787) for IOPpeak, and 13.61 +/- 2.56 mmHg and 15.11 +/- 2.84 mmHg (p <= 0.0001, r=0.824) for IOPmin, respectively, and a positive correlation was present between these values. Conclusion There was a positive correlation between the peak, minimum, and mean IOP values determined using the mDTC and WDT in treated XFG patients. WDT can be used as an alternative in the assessment of the IOP in these patients as a more practical method.Öğe Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma(Hindawi Ltd, 2018) Firat, Penpe Gul; Demirel, Ersan Ersin; Dikci, Seyhan; Kuku, Irfan; Genc, OguzhanPurpose. Iron deficiency anemia is an important public health problem. Also it is considered to be a risk factor for many diseases. The study demonstrates the iron deficiency anemia frequency in glaucoma patients and compares with the normal subjects. We aimed to determine the iron deficiency anemia frequency in glaucoma patients. Methods. Prospective, controlled study in a single university hospital setting. A total of 130 normal subjects (Group 1) and 131 glaucoma patients (Group 2) were included. The erythrocytes parameters, hemoglobin, red blood cell, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and red blood cell distribution width, and iron status indicators, Fe (iron), total iron binding capacity, and ferritin of the cases, in normal subjects and glaucoma patients were compared. Results. There was no statistically significant difference for the erythrocyte parameters between the groups (p >= 0.05). The number of the patients with iron deficiency anemia in both groups was similar. No statistically significant difference was found in the comparison of erythrocyte parameters and iron status indicators values according to the number of antiglaucomatous agents and visual field changes according to the presence of anemia in Group 2 (p >= 0.05). A statistically significant difference was found only in MCH when the erythrocyte parameters and iron status indicators values of the cases in glaucoma patients were compared with the glaucoma duration (p<0.05). Conclusion. The iron deficiency anemia frequency was like the normal population in glaucoma patients.Öğe Evaluation of ıron deficiency anemia frequency as a risk factor in glaucoma(Hındawı ltd, adam house, 3rd flr, 1 fıtzroy sq, london, w1t 5hf, england, 2018) Firat, Penpe Gul; Demirel, Ersan Ersin; Dikci, Seyhan; Kuku, Irfan; Genc, OguzhanPurpose. Iron deficiency anemia is an important public health problem. Also it is considered to be a risk factor for many diseases. The study demonstrates the iron deficiency anemia frequency in glaucoma patients and compares with the normal subjects. We aimed to determine the iron deficiency anemia frequency in glaucoma patients. Methods. Prospective, controlled study in a single university hospital setting. A total of 130 normal subjects (Group 1) and 131 glaucoma patients (Group 2) were included. The erythrocytes parameters, hemoglobin, red blood cell, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and red blood cell distribution width, and iron status indicators, Fe (iron), total iron binding capacity, and ferritin of the cases, in normal subjects and glaucoma patients were compared. Results. There was no statistically significant difference for the erythrocyte parameters between the groups (p >= 0.05). The number of the patients with iron deficiency anemia in both groups was similar. No statistically significant difference was found in the comparison of erythrocyte parameters and iron status indicators values according to the number of antiglaucomatous agents and visual field changes according to the presence of anemia in Group 2 (p >= 0.05). A statistically significant difference was found only in MCH when the erythrocyte parameters and iron status indicators values of the cases in glaucoma patients were compared with the glaucoma duration (p<0.05). Conclusion. The iron deficiency anemia frequency was like the normal population in glaucoma patients.Öğe Göz kapağında nadir bir psödolenfoma: jessner in lenfositik infiltrasyonu (jlıs)(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2014) Dikci, SeyhanJessner'in lenfositik infiltrasyonu derinin etyolojisi bilinmeyen nadir, benign bir hastalığıdır. Sıklıkla orta yaştaki bireylerde baş, boyun ve gövdenin üst kısmında görülmektedir. Çocuklar nadiren etkilenmektedir. Aylarca ya da yıllarca sebat edebilen lezyonlar, kendiliğinden gerileyebilmekte ve genellikle birkaç yıl içinde nüksetme eğilimindedir. Deri lezyonlarının oldukça benzerlik gösterdiği kutanöz lupus eritematozis başta olmak üzere benign lenfoid hiperplastik patolojiler ve malign lenfoma ayırıcı tanıda düşünülmelidir. Jessner'in lenfositik infiltrasyonunun tedavisi tatmin edici değildir ve tedavide sınırlı yararı olan ampirik yöntemler denenmiştir. Bu yazıda nadir bir ortaya çıkış şekli olarak göz kapağı ve çevresine sınırlı lezyonları olan ve Jessner'in lenfositik infiltrasyonu tanısı alan otuz dokuz yaşındaki erkek hastayı sunduk.Öğe Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma(Taylor & Francis Inc, 2019) Firat, Penpe Gul; Demirel, Ersan Ersin; Demirel, Soner; Dikci, Seyhan; Turkoz, Yusuf; Ozyalin, FatmaPurpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.Patients and Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry.Results: A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls (p =0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels.Conclusion: The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.Öğe Kazara Lens İçi Deksametazon İmplant Enjeksiyonu: İki Olgu Sunumu(Glokom Katarakt, 2017) Yılmaz, Turgut; Yeşilöz, Özgür; Tuncer, İlknur; Fırat, Murat; Genç, Oğuzhan; Dikci, SeyhanÖz: İntravitreal deksametazon implant (Ozurdex®, Allergan, USA) retina ven tıkanıklıkları (RVT) yanında diyabet ve üveit gibi nedenlere bağlı maküler ödem tedavisinde günümüzde sıkça kullanılmaktadır. Bu uygulamanın en sık görülen yan etkileri göz içi basınç artışı ve katarakt gelişimidir. Bu çalışmada intravitreal deksametazon implant uygulamasının nadir bir komplikasyonu olarak retinal ven tıkanıklığına bağlı maküla ödemi nedeniyle intravitreal uygulanması planlanan ancak implantın yanlışlıkla lens içine yerleştiği iki olguyu sunmak amaçlandı. Lens içine enjeksiyon nedenleri arasında hekim dikkatsizliği, hasta uyumsuzluğu, lokal anestezi tipi, enjeksiyon sahasının limbusa uzaklığı, hipotoni, skleral zayıfl ık, tekrarlayan enjeksiyonlara bağlı lensi tutan zonüllerde hasar oluşması ile lens pozisyonun değişmesi sayılabilir.Bu nadir komplikasyondan kaçınmak için özellikle implant uygulamaları sırasında enjeksiyon tekniğinin iyi bilinmesi önem taşımaktadır.
