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    Assessment of left atrial volume and mechanical functions using real-time three-dimensional echocardiography in patients with mitral annular calcification
    (Turkish Soc Cardiology, 2016) Bayramoglu, Adil; Tasolar, Hakan; Otlu, Yilmaz Omur; Hidayet, Siho; Kurt, Fuat; Dogan, Adil; Pekdemir, Hasan
    Objective: Mitral annular calcification (MAC) is degeneration of the fibrous annular ring of the mitral valve. Left atrial (LA) function and volume have been evaluated by many methods; however, none have used real-time three-dimensional echocardiography (RT3DE) in patients with MAC. Our study is the first to evaluate LA volume and mechanical function using RT3DE in patients with MAC. Methods: Our study was a prospective cross-sectional study. In total, 32 patients with echocardiographic evidence of MAC and 30 volunteers without MAC were enrolled in the study. Kolmogorov-Smirnov test, Student's t-test, Mann-Whitney U test, chi-square test, Pearson's correlation test, and multiple linear regression analyses were used in this study. Results: LA diameter was significantly higher in patients with MAC (38.5 +/- 3.8 vs. 31.1 +/- 2.9, p<0.001). Maximum LA volume (49.6 +/- 11.2 vs. 35.6 +/- 2.5, p<0.001), minimum LA volume (23.8 +/- 7.9 vs. 12.6 +/- 2.3, p<0.001), and LA volume index (LAVI) (26.9 +/- 6.1 vs. 20.5 +/- 2.4, p<0.001) were also higher in the MAC group. LAVI was correlated with age (p<0.001), blood urea nitrogen levels (p=0.089), total cholesterol levels (p=0.055), left ventricular systolic myocardial velocity (p=0.048), E/A ratio (p<0.001), and MAC (p<0.001). Multiple linear regression analyses revealed that age (beta=0.390, p<0.001) and MAC (beta=0.527, p<0.001) were independent predictors of LAVI. Conclusion: We found that LA mechanical function was impaired in patients with MAC. Furthermore, age and MAC were independent predictors of increased LAVI according to our RT3DE examination.
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    The evaluation of the optic nerve in multiple sclerosis using MRI histogram analysis
    (2020) Dogan, Adil; Baykara, Murat
    Aim: Comparison of optic nerve with healthy subjects by MRI histogram analysis in patients with multiple sclerosis (MS). Material and Methods: A total of 78 patients with age range of 39 ms (18-54), 27 females, 12 males and 39 healthy age range (19-54), 26 females and 13 males (control group) were included in the study. The right optic nerve in the MS and control group was included in the study. ROI was placed on the optic nerve from the images and numerical data were obtained by histogram analysis. Numerical data were loaded into MATLAB program.Results: Mean, standard deviation, minimum, maximum, median, variance and entropy values were significantly higher in MS patients than control group(p0.05). In MS patients, changes in tissue histology were detected in the optic nerve compared to healthy individuals by mri histogram analysis without a visual change in the optic nerve.Conclusion: We think that the diagnosis of optic neuritis, which has an important role in disability in MS patients, will improve the quality of life of patients with early diagnosis and treatment by MRI histogram analysis of the optic nerve.
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    Evaluation of Vertebral Artery Involvement by Doppler Sonography in Patients With Behcet Disease
    (Wiley, 2014) Tasolar, Sevgi; Dogan, Metin; Tasolar, Hakan; Kahraman, Aysegul; Kamisli, Suat; Dogan, Adil; Yildirim, Okan
    Objectives-Neurologic lesions in Behcet disease are most frequently observed in areas supplied by the vertebrobasilar system. We aimed to evaluate possible vertebral artery involvement by Doppler sonography in patients with Behcet disease. Methods-Forty-five patients with Behcet disease and 29 healthy volunteers had Doppler sonography of the vertebral arteries. Patients were grouped according to neurologic examination and magnetic resonance imaging findings as follows: group 1, Behcet disease without neurologic involvement; group 2, neuro-Behcet disease; and group 3, control. Results were assessed with a 95% confidence interval. Results-The main findings of our study were as follows: (1) total vertebral artery volume flow was significantly lower in the patient groups than the control group (P < .05); (2) total volume flow was lower in group 2 than group 1, although the difference was not statistically significant; (3) peak systolic and end-diastolic velocity values were significantly lower in the patient groups than the control group; (4) right and left mean volume values were lower in group 2; and (5) resistive and pulsatility index values for the left vertebral artery were significantly higher in group 2, but no statistically significant differences were found in the resistive and pulsatility index values for the right vertebral artery. Conclusions-Doppler sonography of the vertebral arteries in Behcet disease shows alterations that may aid in the diagnosis and treatment of this condition.