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    Comparison of bipolarity features between art students and other university students
    (2019) Kocamer Sahin, Sengul; Demir, Ahmet; Elboga, Gulcin; Altindag, Abdurrahman; Dogan, Ilkay
    Aim: There is a common belief that creativity and artistic talent/creativity are related to psychopathology. Mood disorders are more prominent in studies about relations between creativity and psychopathology. Also patients may be more productive during mania and hypomania periods of bipolar mood disorder. Considering these data, the purpose of this study was to investigate whether there is a predisposition to bipolar disorder in people with artistic creativity. Materials and Methods: A total of 157 students were selected randomly from the Art department and 157 from different departments including Faculties of Law, Science and Literature and Education. Art students had proven their artistic competence by two stage examination. Groups were compared based on mood disorder questionnaire (MDQ) and bipolarity predisposition factors. SPSS 22.0 was used for statistical analyses. Chi-square analysis was used to compare case-control groups according to demographic characteristics.Results: There were no significant differences between the groups in terms of age, sex, education, smoking, marital status, family history of psychiatric disorder. The number of psychiatric admissions were higher in the students of art (p=0.026). Alcohol-substance use was higher among students of Art (p=0.001). The MDQ scale result was 50.3% positive for Art students and 26.8% positive for students from different departments. MDQ scale, the predisposition of bipolar disorder was found to be significantly higher in Art students.Conclusion: The high prevalence of bipolarity features with MDQ scale in art students supports the relationship between artistic talent / creativity and bipolar disorder.
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    Thyroid dysfunction in chronically transfused adults with β-thalassemia major
    (2019) Haydaroglu Sahin, Handan; Dogan, Ilkay
    Aim: This study aims to determine the prevalence and severity of thyroid dysfunction in adult β-thalassemia major (BTM) patients and to investigate its relationship with the frequency of transfusions, serum ferritin levels, and adequacy of oral chelation therapy. Material and Methods: This study included 62 adult patients diagnosed BTM and had been receiving regular blood transfusions for at least 1 year. Iron load was defined as the serum ferritin level. Thyroid dysfunction was categorized as primary hypothyroidism (thyroid-stimulating hormone (TSH)>5.6 mU/L and serum-free thyroxine (FT4)<0.61 ng/dL), subclinical hypothyroidism (Normal FT4 with TSH>5.6 mU/L) or secondary hypothyroidism (FT4<0.61 ng/dL with low or normal TSH). Patients’ data was presented retrospectively. Results: The prevalence of hypothyroidism was 22.6%, and the prevalence of primary hypothyroidism was 14.6%. Mean ferritin levels were determined as 5283.64±2023.95 ug/L, and 1868.67±955.98 ug/L respectively for patients with hypothyroidism, and euthyroidism; and a significant difference was determined between the two groups (p=0.001). Thyroid dysfunction was encountered more frequently in patients receiving four units of blood transfusion per month, and high-dose chelation therapy (both p=0.001). Severity of thyroid dysfunction was determined to have a statistically significant relationship with increased serum TSH, and decreased serum FT4 levels. Conclusion: This study determined primary hypothyroidism as the most common subtype of thyroid dysfunction. A significant relationship was found between thyroid dysfunction and serum ferritin levels. In view of these data; reducing the incidence of thyroid dysfunction appears to be possible through successful management of iron chelation therapy in patients receiving regular blood transfusions.