Thyroid dysfunction in chronically transfused adults with β-thalassemia major
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: This study aims to determine the prevalence and severity of thyroid dysfunction in adult β-thalassemia major (BTM) patients
and to investigate its relationship with the frequency of transfusions, serum ferritin levels, and adequacy of oral chelation therapy.
Material and Methods: This study included 62 adult patients diagnosed BTM and had been receiving regular blood transfusions for
at least 1 year. Iron load was defined as the serum ferritin level. Thyroid dysfunction was categorized as primary hypothyroidism
(thyroid-stimulating hormone (TSH)>5.6 mU/L and serum-free thyroxine (FT4)<0.61 ng/dL), subclinical hypothyroidism (Normal
FT4 with TSH>5.6 mU/L) or secondary hypothyroidism (FT4<0.61 ng/dL with low or normal TSH). Patients’ data was presented
retrospectively.
Results: The prevalence of hypothyroidism was 22.6%, and the prevalence of primary hypothyroidism was 14.6%. Mean ferritin
levels were determined as 5283.64±2023.95 ug/L, and 1868.67±955.98 ug/L respectively for patients with hypothyroidism, and
euthyroidism; and a significant difference was determined between the two groups (p=0.001). Thyroid dysfunction was encountered
more frequently in patients receiving four units of blood transfusion per month, and high-dose chelation therapy (both p=0.001).
Severity of thyroid dysfunction was determined to have a statistically significant relationship with increased serum TSH, and
decreased serum FT4 levels.
Conclusion: This study determined primary hypothyroidism as the most common subtype of thyroid dysfunction. A significant
relationship was found between thyroid dysfunction and serum ferritin levels. In view of these data; reducing the incidence of thyroid
dysfunction appears to be possible through successful management of iron chelation therapy in patients receiving regular blood
transfusions.
Açıklama
Anahtar Kelimeler
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Haydaroglu Sahin, H., & Dogan, I. (2021). Thyroid dysfunction in chronically transfused adults with β-thalassemia major . Annals of Medical Research
