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Öğe Active silicone oil removal with 23 gauge transconjunctival system; ‘’Doganay silicone oil extraction system’’(2019) Doganay, Derya; Doganay, Selim; Cankaya, CemAim: To describe a new and simple silicone oil removal method with 23-gauge (G) transconjunctival vitrectomy system. Material and Methods: This is a prospective, single center, interventional clinical trial. A hundred thirty-three eyes of 133 patients were enrolled in this study. 1000 centistoke (cSt) silicone oil was removed with our new method. Main outcome measurements were silicone oil removal time, number of sutured 23 G sclerotomy sites, intraoperative and postoperative complications, preoperative and postoperative intraocular pressure (IOP) alterations, and preoperative and postoperative visual acuity changes. Results: The mean time between pars plana vitrectomy surgery with silicone oil endotamponade and silicone oil removal was 8.5±3.5 months. Mean silicone oil removal time was 141.7±37.7 seconds. 210 of total 293 sclerotomies sites required suture. A statistically significant decrease in postoperative IOP was found only on day 1 (p<0.05). Mean preoperative (before silicone oil removal) best correct visual acuity (BCVA) was LogMAR 1.39±0.74 and mean postoperative BCVA at the final visit was LogMAR 1.23±0.88 (p<0.05). Mean postoperative follow-up was 7.2±6.2 months. Postoperative transient hypotony occurred in 23 eyes (IOP < 7 mm-Hg), revitreous hemorrhage occurred in 5 eyes and retinal re-detachment occurred in 7 (5.3%) eyes. Conclusion: Removal of 1000 cSt silicone oil with our new method is effective, safe, easy, and fast.Öğe The Alterations of the Anterior Chamber Parameters Measured with Pentacam with Age in Healthy Subjects(Turkish Ophthalmological Soc, 2008) Emre, Sinan; Koc, Bekir; Doganay, Selim; Yologlu, SaimPurpose: To determine the mean values and standard deviations of anterior chamber parameters with pentacam and evaluate the alterations of these parameters with age. Material-Method: 224 eyes of 112 patients with just basic refractive errors were included in this study. After complete ophthalmologic examination of patients, under standard conditions anterior chamber parameters were measured with pentacam. Central corneal thickness (CCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber angle (ACA), and also horizontal, vertical and mean keratometry values were recorded with pentacam. Results: 55 female and 57 male patients were included in this study. Mean age of patients was 28.57. Mean of the keratometric measurements was 43.1 D. Mean values for CCT, ACD, CV, ACV and ACA were 534 mu m, 3.14 mm, 59.77 mm(3), 190.26 mm(3), 36.88 degrees, respectively. Evaluation of parameters according to gender and eye distribution did not reveale any difference. Analysis the effect of age on CCT, ACD, CV, ACV and ACA parameters documented statistical significance (p< 0.005) and correlation coefficents were r=-0.185, -0.373, -0.263, -0.320, -0.264, respectively. Conclusion: This study documented the negative effect of age on the anterior chamber parameters with different correlation coefficients.Öğe Assessment of ganglion cell complex, macular thickness, and optic disc parameters in keratoconus patients(Wolters Kluwer Medknow Publications, 2020) Orman, Gozde; Firat, Penpe Gul; Doganay, Selim; Doganay, DeryaPURPOSE: Keratoconus (KC) is bilateral noninflammatory corneal disorder characterized by progressive corneal thinning, protrusion, and scarring. The purpose of this study was to evaluate ganglion cell complex(GCC), macula thickness(MT) and optic head disc parameters in keratoconus patients. METHODS: A hospital based prospective clinical case series was performed in Inonu University School of Medicine. 52 eyes of 52 keratoconus patients and 50 eyes of 50 normal patients were enrolled. RESULTS: There is no statistically significant in MT between groups. GCC in nasal superior, temporal superior and temporal inferior 9 mm from macula were found statistically significant decrease in keratoconus group (p<0,05). In optic disc analysis fifth and the eleventh clock-hour quadrants of peripapiller retina nerve fiber layer and cup area ratio were found statistically significant decrease in keratoconic eyes (p<0,05). CONCLUSION: We thought that structural retinal changes seem in keratoconus eyes; keratoconus pathogenesis may affect not only cornea but also retina and optic nerve head.Öğe Bilateral Aniridia Lenticular Coloboma and Snowflake Retinal Degeneration(Slack Inc, 2009) Doganay, Selim; Emre, Sinan; Firat, PenpeguelA 6-year-old boy presented with bilateral aniridia associated with lens coloboma and snowflake retinal degeneration. Ophthalmologic examination revealed bilateral corneal peripheral epithelial thickening and aniridia. Additionally, the patient had lenticular coloboma and snowflake retinal degeneration in both eyes. Intraocular pressure was 22 mm Hg bilaterally. The patient also had pendular nystagmus. Uncorrected visual acuity was counting fingers at 2 meters for both eyes, but improved to 0.2 and 0.05, respectively, with correction. Congenital aniridia has been reported with various ophthalmic pathologies, but this is the first case to display bilateral lenticular coloboma and snowflake retinal degeneration associated with aniridia. [Ophthalmic Surg Lasers Imaging 2009;40:54-56.]Öğe Bilateral Congenital Cystic Eye Posterior to the Lower Eyelid: Case Report(Ortadogu Ad Pres & Publ Co, 2012) Doganay, Selim; Alkan, Alpay; Cankaya, Cem; Firat, PenbegulOne day after delivery, an infant boy was referred to our clinic with the complaint of bilateral inferior eyelid bluish discoloration and absence of globe in orbital space. External ocular examination showed no globe in orbital space but a mild bulging of the right and left lower eyelid with an area of bluish discoloration. There were no other ocular or non-ocular abnormalities. Systemic evaluation was normal. Magnetic resonance imaging (MRI) confirmed presence of bilateral cystic eye and absence of ocular structures in orbital space. MRI at age of 14 months showed enlargement of the left cystic eye. A clear fluid (5 cc) was aspirated from the cyst to restore the globe size within the lower eyelid. Biochemical analysis of cystic fluid revealed no abnormalities.Öğe BILATERAL SEMINAL VESICLE AND UNILATERAL RENAL AGENESIS IN CASE WITH PRIMARY INFERTILISM(Aves, 2007) Erdem, Glnur; Karakas, Hakki Muammer; Ugras, Murat; Alkan, Alpay; Altinok, Tayfun; Doganay, SelimIntroduction: Agenesia of the seminal vesicle is an uncommon cause of the male infertility. While unilateral agenesia of seminal vesicle is observed in 0.6-1% of male population, bilateral agenesia is extremely rare. These malformations may be associated with unilateral or bilateral agenesia of the vas deferens or unilateral renal agenesia. 70-80% of the cases with bilateral agenesia of the seminal vesicle have gene mutations related to cystic fibrosis. In his article we presented the ultrasonographic and magnetic resonance imaging findings of bilateral agenesia of the seminal vesicle and unilateral renal agenesia in primary infertile case who has not cystic fibrosis. Materials and Methods: Pelvic magnetic resonance imaging (MRI) and abdominal ultrasonography was utilized in 29 years old male patient with primary infertility. Results: Bilateral seminal vesicle agenesis was found in MRI. In spermiogram, neither live nor dead spermium was detected. Abdominal ultrasonography was yielded as unilateral renal agenesis and contralateral compensatris hypertrophy consecutively on left and right sides. Conclusion: Pelvic and transrectal ultrasonography gives valuable data on investigation of the etiology of primary infertility. Pelvic MRI is important to distinguish the hypoplasia and the agenesis of the seminal vesicle.Öğe Changes in Anterior Chamber Parameters with the Pentacam Rotating Scheimpflug and Axial Length Measurements by Ultrasound in Patients Who Use Isotretinoin(Informa Healthcare, 2012) Cumurcu, Tongabay; Sener, Serpil; Ozsoy, Ercan; Doganay, SelimPurpose: Evaluation of changes in anterior chamber parameters with the Pentacam rotating Scheimpflug and axial length measurements (Alx) by ultrasound in patients who use isotretinoin for the treatment of acne vulgaris. Methods: Twenty-nine eyes of 29 patients (15 men, 14 women) were evaluated with the Pentacam before the treatment, and at the 3rd and 6th months of treatment. The axial length was evaluated by ultrasound biometry. The non-parametric paired t-test was used to compare pretreatment and 3rd and 6th month anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), lens thickness (LT), pupil size, axial length measurement (Alx) and mean keratometry values (K). Results: The mean age of the patients was 21.82 +/- 4.14 years. The differences between the pretreatment and 3rd and 6th month ACD, ACV, CCT, Alx, LT and mean K values were statistically significant (p < 0.05). The differences between the pretreatment and 3rd and 6th month pupil size measurements were not statistically significant (p > 0.05). The differences between the pretreatment and 3rd month ACA measurements were statistically significant (p > 0.05), but there was no statistically significant difference with 6th month values (p < 0.05). Conclusions: Isotretinoin treatment causes statistically significant changes in most anterior segment parameters during treatment.Öğe Comparison of ganglion cell and retinal nerve fiber layer thickness in primary open-angle glaucoma and normal tension glaucoma with spectral-domain OCT(Springer, 2013) Firat, Penpe Gul; Doganay, Selim; Demirel, Ersan Ersin; Colak, CemilThe aim of this study was to evaluate the macular thickness (MT), ganglion cell complex (GCC), and circum-papillary retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) with spectral domain optical coherence tomography (SD-OCT). A total of 169 subjects were enrolled: 52 normal subjects, 61 with POAG, and 56 with NTG. Spectral-domain optical coherence tomography (SD-OCT) was used to analyze MT, GCC, and RNFL thickness. To compare the discrimination capabilities between the MT, GCC, and RNFL thickness measurements, we analyzed the areas under the receiver operating characteristic (ROC) curves (AUCs). The relationships between GCC and RNFL measurement and also the relationships of the groups, with age, gender, GCC, and RNFL thickness were assessed. Normal subjects showed the thickest superior and inferior GCC, followed by in order NTG and POAG (p < 0.05). While there was a statistically difference in MT value of the normal subjects and the glaucoma patients (p < 0.05), MT value did not differ between POAG and NTG (p < 0.05). RNFL thickness parameters were significantly greater in normal subjects, followed in order by the NTG, and POAG (p < 0.05). Between the normal and entire glaucoma groups, all GCC and RNFL parameters showed the similar discrimination power. RNFL thickness parameters correlated significantly with all GCC thickness (p < 0.05). Superior RNFL thickness was the only independent variable between the POAG and NTG patients (odds ratio (OR) 0.942, p = 0.004, 95 %CI 0.905-0.981). SD-OCT evaluation results suggest higher GCC and RNFL parameters for NTG than POAG.Öğe Corneal tattooing for esthetic purposes in patients with corneal opacities(Wolters Kluwer Medknow Publications, 2020) Doganay, Derya; Doganay, Selim; Cankaya, CemPurpose: This study evaluated corneal tattooing for esthetic purposes in patients with corneal opacification. Methods: Eight eyes of eight patients were included in the study (four males and four females). Corneal tattooing was achieved by stromal puncture in five patients, femtosecond laser-assisted corneal tattooing in two patients, and femtosecond laser-assisted corneal tattooing and stromal needling (combined procedure) in one patient. In six of the patients, the entire cornea was stained black; in one patient, the center of the cornea (3 mm) was stained black and the periphery was stained dark brown; and in the last patient, the corneal periphery was stained dark brown. Patient satisfaction was evaluated on the first day after surgery and at the last visit as follows: Very satisfied (4), satisfied (3), moderately satisfied (3), and not satisfied (1). Results: The patients ranged in age from 11-80 years. The mean satisfaction score of the patients was 4 and 3.5 on the first postoperative day and at the last visit, respectively. No complication occurred during or after surgery. Conclusion: Corneal tattooing for esthetic purposes was successful in both blind eyes and seeing eyes.Öğe The effect of apricots on the experimental cataract model formed by sodium selenite(Pergamon-Elsevier Science Ltd, 2013) Doganay, Selim; Duz, Cem; Firat, Penpe Gul; Cankaya, Cem; Kutukde, Derya; Cigremis, YilmazThis study was designed in order to investigate whether sun dried apricots have a preventive effect on the experimental cataract model formed by sodium selenite in rats. Fifty-nine Spraque-Dawley rat pups were divided into three groups. Group I (control group) consisted of twenty rat pups, born from the rats nourished ad libitum. Group 2 consisted of 18 newborn rats, born from the rats nourished ad libitum with 10% sun dried natural apricots. Group 3 consisted of 21 newborn rats, born from the rats nourished ad libitum. Subcutaneous (30 nmol/gr) sodium selenite injection was applied to all the newborn rats except the control group (Group 1) on postpartum day 10. Cataract development was graded by slit-lamp examination and photography. Encapsulated lenses were analyzed for reduced glutathione (GSH) and malondialdehyde (MDA), a marker of lipid per oxidation. Lenses were also analyzed for total nitrite (TN). The presence of oxidative stress in selenite cataract development and its prevention by sun dried apricots. (C) 2013 Elsevier Ltd. All rights reserved.Öğe Effect of the preservation-to-surgery interval on corneal allograft survival in low-risk patients(Slack Inc, 2007) Doganay, Selim; Hepsen, I. Fevzi; Yologlu, Saim; Demirtas, Hakanm BACKGROUND AND OBJECTIVE: To investigate the role of the preservation-to-surgery interval on corneal allograft survival in low-risk patients. PATIENTS AND METHODS: Eighteen donor corneas obtained from an overseas eye bank were preserved and transported overseas in Optisol-GS solution (Chiron Vision, Irvine, CA) in Group 1. Thirty fresh, young, healthy, and unscreened donor corneas soaked in the same medium were used in Group 2. Average preservation-to-surgery time was more than 8 days in Group 1 and less than 30 hours in Group 2. Corneal allograft survival rates were determined by Kaplan-Meier estimates of the survivor functions. The log-rank test was used to determine statistical significance of the differences between groups. RESULTS: The mean preservation-to-surgery interval was 233.3 +/- 37.7 hours in Group I and 20.8 +/- 4.6 hours in Group 2 (P <.05 for the comparison of average times). There were significant differences between the groups with respect to donors' age and enucleation time, but there were no statistically significant differences between the groups in terms of graft diameter and recipient diameter or for corneal allograft survival in low-risk patients. The graft survival rate was 83.3% in Group I and 93.3% in Group 2 at the end of the follow-up period. CONCLUSIONS: Preservation-to-surgery time has no effect on corneal allograft survival in low-risk patients. However, prospective, randomized, long-term and large-scale clinical trials are necessary to confirm these findings.Öğe Effective management of exposure keratopathy developed in intensive care units: The impact of an evidence based eye care education programme(Elsevier Sci Ltd, 2014) Demirel, Soner; Cumurcu, Tongabay; Firat, Penpegul; Aydogan, Mustafa Said; Doganay, SelimObjectives: To assess the impact of eye care education on the incidence of corneal exposure in intensive care units (ICU). Research methodology/design: Approximately 300 ICU personnel were educated about eye care to reduce the incidence of corneal exposure. The patients were divided into two groups: pretraining (Group 1: Between February 1, 2011 and March 31, 2011 [2 months]) and post-training periods (Group 2: Between April 1, 2011 and April 1 2012 [1 year]). We compared the groups for keratopathy incidence to evaluate the efficacy of this education. Results: The number of patients were 762 in Group 1 and 6196 in Group 2 (p=0.335). Medians of patients followed in pre training ICU and post training ICU for each month were found to be 476 (interquartile range, 433-539) and 515 (interquartile range, 490-528). Exposure keratopathy was identified in 8 eyes of 6 patients (3 males and 3 females) in pre training ICU with the mean age of 27.6 +/- 31.8 years and 5 eyes of 3 patients (1 male and 2 females) in post training ICU with the mean age of 41.3 +/- 32.1 years. No significant difference was noticed between two groups in terms of the medians of patients followed in ICUs for each month (p =0.335). The time of hospitalisation in ICU when the patients were consulted for the first ocular assessment in pre training ICU and post training ICU were found to be 13 +/- 8.7 days and 8 +/- 1.7 days, respectively. After the training, the decrease in incidence of exposure keratopathy was found to be highly significant (p<0.001). Conclusion: We observed a highly significant reduction in the incidence of corneal exposure, following the eye-care education programme. (C) 2013 Published by Elsevier Ltd.Öğe Effects of third generation mobile phone-emitted electromagnetic radiation on oxidative stress parameters in eye tissue and blood of rats(Taylor & Francis Ltd, 2012) Demirel, Soner; Doganay, Selim; Turkoz, Yusuf; Dogan, Zumrut; Turan, Bahadir; Firat, Penpe Gul BozgulPurpose: To investigate the effects of electromagnetic radiation (EMR) emitted by a third generation (3G) mobile phone on the antioxidant and oxidative stress parameters in eye tissue and blood of rats. Methods: Eighteen Wistar albino rats were randomly assigned into two groups: Group I (n = 9) received a standardized a daily dose of 3G mobile phone EMR for 20 days, and Group II served as the control group (n = 9), receiving no exposure to EMR. Glutathione peroxidase (GSH-Px) and catalase (CAT) levels were measured in eye tissues; in addition, malondialdehyde (MDA) and reduced GSH levels were measured in blood. Results: There was no significant difference between groups in GSH-Px (p = 0.99) and CAT (p = 0.18) activity in eye tissue. There was no significant difference between groups in MDA (p = 0.69) and GSH levels (p = 0.83) in blood. Conclusions: The results of this study suggest that under a short period of exposure, 3G mobile phone radiation does not lead to harmful effects on eye tissue and blood in rats.Öğe Endoscopic Transcanalicular Diode Laser Dacryocystorhinostomy: Is It an Alternative Method to Conventional External Dacryocystorhinostomy?(Lippincott Williams & Wilkins, 2013) Derya, Kutukde; Demirel, Soner; Doganay, Selim; Orman, Gozde; Cumurcu, Tongabay; Gunduz, AbuzerPurpose: To compare the success rates of endoscopic transcanalicular diode laser dacryocystorhinostomy (EL-DCR) and external DCR. Materials and Methods: Operations were performed on 55 eyes of 54 patients who had distal nasolacrimal canal obstruction. External DCR was performed on 29 of the eyes and EL-DCR on 26 of them. Success was defined based on subjective relief of patients reported at their final examinations. Results: There were 23 women and 6 men in group 1 and 19 women and 6 men in group 2 (p = 0.77). The mean ages of groups were 45.24 +/- 12.08 (range, 15-74) and 43.2 +/- 17.01 (range, 11-72) years, respectively (p = 0.63). The mean follow-up times were 8.82 +/- 5.51 (range, 3-18) and 7.12 +/- 2.96 (range, 2-12) months, respectively in groups (p = 0.58). The success rates based on symptoms were measured at 25 of 29 (86%) and 17 of 25 (68%) for 2 groups. The difference in the success rates was higher but not found to be statistically significant (p = 0.202). The authors found various conditions related to nasal passage in 4 of 8 unsuccessful EL-DCR, including allergic rhinitis, nasal crust, silicone tube reaction, and unsuitable passage for endoscopic surgery. Conclusions: The success rate of EL-DCR was lower than that of the external DCR; however, no statistically significant difference was observed. Endoscopic transcanalicular diode laser DCR may be considered as an alternative method to external DCR with these results. (Ophthal Plast Reconstr Surg 2013;29:15-17)Öğe Evaluation of anterior segment parameter changes using the Pentacam after uneventful phacoemulsification(Wiley-Blackwell, 2010) Doganay, Selim; Bozgul Firat, Penpegul; Emre, Sinan; Yologlu, SaimPurpose: This study set out to evaluate the influences of uneventful phacoemulsification on the anterior segment parameters obtained with the Pentacam rotating Scheimpflug camera and intraocular pressure (IOP). Methods: A total of 42 eyes of 34 patients (26 men, eight women) were evaluated preoperatively, and at 1, 3 and 6 months postoperatively with the Pentacam. Intraocular pressure was measured with the Goldmann applanation tonometer. The non-parametric paired t-test was used to compare preoperative and 1-, 3- and 6-month postoperative measurements of anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), the central 3-, 5- and 7-mm corneal volume (CV), pupil size, and IOP. Pearson's correlation test was used to evaluate the relationships between IOP and ACD, ACV and ACA width. Results: The differences between ACD, ACV, ACA and IOP values taken preoperatively and those taken postoperatively at 1, 3 and 6 months were statistically significant (p < 0.05). The differences between CCT, central 3-, 5- and 7-mm CV, and pupil size measurements taken preoperatively and those taken postoperatively at 1, 3 and 6 months were not statistically significant (p > 0.05). The decrease in IOP was not correlated with the changes in ACD, ACV and ACA (p > 0.05). Conclusions: Uneventful phacoemulsification significantly reduced IOP, increased ACD and ACV, and widened the ACA. However, alterations in CV, CCT and pupil size values were not statistically significant. Alterations in ACD, ACV, ACA and IOP remain stable after the first month of surgery.Öğe Evaluation of anterior segment parameters in keratoconic eyes measured with the Pentacam system(Elsevier Science Inc, 2007) Emre, Sinan; Doganay, Selim; Yologlu, SaimPURPOSE: To evaluate the alteration in anterior chamber parameters with the progression of keratoconus using a rotating Scheimpflug camera. SETTING: Inonu University, Turgut Ozal Medical Center, Ophthalmology Department, Malatya, Turkey. METHODS: Two hundred sixteen eyes of 123 patients diagnosed with keratoconus and 224 eyes of 112 normal subjects were evaluated with a Pentacam Scheimpflug camera (Oculus Inc.). Keratoconic eyes were divided into 3 groups according to mean keratometer (K) readings: mild (K = less than 47.0 diopters [D]), moderate (K = 47.0 to 52.0 D), and severe (K = 52.0 D or higher). The following parameters were obtained: thinnest corneal thickness (TCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber angle (ACA), and anterior chamber volume (ACV). RESULTS: One hundred twenty-nine eyes had mild keratoconus, 59 had moderate keratoconus, and 35 had severe keratoconus. There were no statistically significant differences between the keratoconus group and control group in age, sex, or eye distribution (P>.05). With the progression of the disease, TCT and ACID were statistically different between all groups (P<.05). There were statistically significant differences in ACA and CV measurements between the mild keratoconus and severe keratoconus groups (P<.05). Also, CV readings were significantly different between the control group and all keratoconus groups (P<.05), although there was no significant difference in ACA measurements (P>.05). Despite a progressive increase in the ACV with disease progression, the differences between groups were not statistically significant (P>.05) except between the severe keratoconus group and the control group (P<.05). CONCLUSION: Anterior segment parameters of the eye showed significant alterations with the progression of keratoconus.Öğe Evaluation of Antimicrobial Activities of Topical Anesthetics(Ortadogu Ad Pres & Publ Co, 2011) Orman, Gozde; Cankaya, Cem; Doganay, Selim; Gunal, Selami; Otlu, BarisObjective: To investigate the antimicrobial activities of the drugs used as topical anesthetics. Material and Methods: Test drugs (oxybuprocaine 0.4%, proparacaine hydrochloride 0.5%, lidocaine 10%) were tested for Staphylococcus aureus (S. aureus) ATCC 29213, Streptococcus pneumoniae (S. pneumoniae)ATCC 27336, Pseudomonas aeruginosa (P. aeruginosa) ATCC 27853, standard strains of Escherichia coli (E. coli) ATCC 25922 and Candida albicans (C. albicans) using modified microplate alamar blue method (MABA) in different concentrations according to Clinical and Laboratory Standards Institute (CLSI) criteria. Results: S. Pneumoniae proliferated in none of the dilutions of three topical anesthetics. S. aureus proliferated in all dilutions of oxybuprocaine and lidocaine and in no dilutions of proparacaine hydrochloride. P. Aeruginosa proliferated in 0.2% dilution of oxybuprocaine and 2.5% and 5% dilutions of lidocaine and in all dilutions of proparacaine hydrochloride. C. albicans proliferated in 0.05% and 0.025 % dilutions of oxybuprocaine, 1.25% and 0.625% dilutions of lidocaine, 0.125%, 0.0625% and 0.0312% dilutions of proparacaine hydrochloride. E. Coll proliferated in all dilutions of oxybuprocaine, 0.625% dilutions of lidocaine and 0.125%, 0.0625% and 0.0312% dilutions of proparacaine hydrochloride. Conclusio: Topical anesthetics that are used before sample collection in superficial ocular infections can cause false results in cultures by inhibating proliferations of microorganisms. Thus, it is important to know the effects of topical anesthetics and dilutions on bacterial proliferation.Öğe Evaluation of corneal biomechanical properties after uneventful standard coaxial phacoemulsification surgery(2018) Cankaya, Cem; Ulas, Fatih; Doganay, Derya; Firat, Penpegul; Doganay, SelimAim: This study was designed to investigate the alteration of intraocular pressure measurements and biomechanical properties of the cornea in patients who underwent uneventful standard coaxial phacoemulsification cataract surgery through 2.75 mm corneal main incision with intraocular lens implantation. Material and Methods: 15 eyes of 15 patients admitted to our clinic because of the cataract problems in the study. Corneal hysteresis (CH), corneal resistance factor (CRF) measurements, Goldmann correlated (IOPg), and corneal compensated intraocular pressure (IOPcc) values were recorded by ocular response analyzer (ORA) before and 1 day, 1 week and 1 month after surgery. Results: The mean age of the patients was 64.3 ± 8.06 years. Preoperative mean CH, CRF, IOPg and IOPcc values were 8.23±2.10, 9.33±2.27, 18.54±3.42 and 19.66±3.22, respectively. The mean CH, CRF, IOPg and IOPcc values were 5.50±2.07, 8.69±2.04, 22.29±3.37 and 23.83±3.32, respectively on the first day after the surgery. The mean CH, CRF, IOPg and IOPcc values were 5.25±1.83, 8.29±2.10, 18.86±2.72 and 20.20±3.37, respectively of the first week after the surgery. The mean CH, CRF, IOPg and IOPcc values were 7.88±1.99, 8.37±1.83, 15.81±2.60 and 16.41±2.80, respectively in the first month after the surgery. Conclusion: These results revealed that the biomechanical properties of the cornea may change during the first one month period after uneventful standard coaxial phacoemulsification surgeryÖğe Evaluation of metabolite changes in visual cortex in diabetic retinopathy by MR-Spectroscopy(Elsevier Science Inc, 2012) Ozsoy, Ercan; Doganay, Selim; Dogan, Metin; Alkan, Alpay; Firat, Penpe GulPurpose: To evaluate metabolite changes in the visual cortex of diabetic patients with nonproliferative or proliferative diabetic retinopathy by Magnetic Resonance Spectroscopy (MRS). Materials and Methods: 15 normal subjects (group 1), 15 patients with diabetes who did not have diabetic retinopathy (group 2), 15 patients with nonproliferative diabetic retinopathy (NPDR) (group 3), and 15 patients with proliferative diabetic retinopathy (PDR) (group 4) were included in the study. Furthermore, diabetic patients were divided into two groups according to HbA1c levels (Group A: 20 patients, HbA1c <8%; Group B: 20 patients, HbA1c >8%). In all cases' left visual cortex, amounts of N-acetyl-aspartate (NAA), choline (Cho), and creatine (Cr) were measured by MRS. NAA/Cr, Cho/Cr, and NAA/Cho ratios were calculated. Furthermore, all cases' complete blood count (CBC) and biochemical parameters were evaluated. Results: There was no statistically significant difference for NAA/Cr, Cho/Cr, and NAA/Cho ratios between groups 1. 2, 3, and 4 (P>0.05). However there was a statistically significant difference for NAA/Cr and NAA/Cho ratios between groups A and B (P<0.05). There was no statistically significant difference for Cho/Cr ratio between groups A and B (P>0.05). Conclusion: Although NAA/Cr and NAA/Cho ratios decrease in the visual cortex while diabetic retinopathy progresses, these decreases are not statistically significant. While HbA1c levels increase, the NAA concentration decreases in the visual cortex which indicates neuronal loss. The metabolite changes in the visual cortex are associated with acute events rather than chronic. (c) 2012 Elsevier Inc. All rights reserved.Öğe Evaluation of Pentacam-Scheimpflug imaging of anterior segment parameters in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma(Wiley, 2012) Doganay, Selim; Tasar, Ahmet; Cankaya, Cem; Firat, Penpe Gul; Yologlu, SaimBackground: The aim was to evaluate anterior segment parameters in patients with pseudoexfoliation syndrome (PXS) or pseudoexfoliative glaucoma (PXG) with the Pentacam-Scheimpflug imaging system. Methods: Eighty eyes of 53 patients with PXS (Group 1), 80 eyes of 57 patients with PXG (Group 2) and 80 eyes of 45 control cases (Group 3) were included in the study. Anterior chamber depth, volume (ACV), angle (ACA) width, central corneal thickness (CCT), central 3.0, 5.0 and 7.0 mm corneal volumes and pupil diameters were compared between groups. Results: Although anterior chamber depths in the PXG group were significantly lower than the control group (p < 0.05), there was no statistically significant difference between the PXS group and the control group in means of anterior chamber depth values (p > 0.05). There were no statistically significant differences among PXS, PXG and the control group in mean values of ACV, ACA width, CCT, pupil diameters and central 3.0, 5.0 and 7.0 mm corneal volume (p > 0.05). Conclusions: The anterior chamber depths of PXG patients were lower than those of healthy individuals. Although the difference in anterior chamber depth between PXG patients and normal patients was statistically significant, this finding is unlikely to be of clinical significance. The anterior chamber depths of PXS patients were similar to those of healthy individuals. There were no significant differences in the means of ACV, ACA width, CCT, pupil diameter and corneal volume values on central 3.0, 5.0 and 7.0 mm among patients with PXS, PXG and healthy individuals.
