Effect of the preservation-to-surgery interval on corneal allograft survival in low-risk patients
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Slack Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
m BACKGROUND AND OBJECTIVE: To investigate the role of the preservation-to-surgery interval on corneal allograft survival in low-risk patients. PATIENTS AND METHODS: Eighteen donor corneas obtained from an overseas eye bank were preserved and transported overseas in Optisol-GS solution (Chiron Vision, Irvine, CA) in Group 1. Thirty fresh, young, healthy, and unscreened donor corneas soaked in the same medium were used in Group 2. Average preservation-to-surgery time was more than 8 days in Group 1 and less than 30 hours in Group 2. Corneal allograft survival rates were determined by Kaplan-Meier estimates of the survivor functions. The log-rank test was used to determine statistical significance of the differences between groups. RESULTS: The mean preservation-to-surgery interval was 233.3 +/- 37.7 hours in Group I and 20.8 +/- 4.6 hours in Group 2 (P <.05 for the comparison of average times). There were significant differences between the groups with respect to donors' age and enucleation time, but there were no statistically significant differences between the groups in terms of graft diameter and recipient diameter or for corneal allograft survival in low-risk patients. The graft survival rate was 83.3% in Group I and 93.3% in Group 2 at the end of the follow-up period. CONCLUSIONS: Preservation-to-surgery time has no effect on corneal allograft survival in low-risk patients. However, prospective, randomized, long-term and large-scale clinical trials are necessary to confirm these findings.
Açıklama
Annual Meeting of the American-Society-of-Cataract-and-Refractive-Surgery -- APR, 2005 -- Washington, DC
Anahtar Kelimeler
Organ-Culture Medium, Langerhans Cells, Dendritic Cells, Storage Time, Donor, Rejection, Transplantation, Tissue
Kaynak
Ophthalmic Surgery Lasers & Imaging
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
38
Sayı
6
