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    The effects of a nonsteroidal anti-inflammatory drug on the degree of titanium implant osseointegration
    (Elsevier B.V., 2020) Toy V.E.; Dundar S.; Bozoglan A.
    Objective: The aim of this study was to histologically examine the effects of a nonsteroidal anti-inflammatory drug, namely diclofenac sodium (DCS), on the extent of the bone–implant contact (BIC) of titanium implants after four weeks of osseointegration period in a rodent model. Material & methods: Fourteen female Sprague-Dawley rats were divided into two groups: the control (n = 7) and experimental (DCS) groups. Fourteen machine-surfaced titanium implants were placed in the right tibial bones of the rats. The DCS (2 mg/kg) was administered by means of oral gavage to the experimental group for 14 days after four weeks of osseointegration. No medication was administered to the control group throughout the six-week study period. At the end of the study, the rodents were sacrificed and block sections were obtained for histologic evaluation. Results: The mean BIC ratios for the control and DCS groups were 64.15 ± 6.31% and 61.10 ± 6.08%, respectively. No statistically significant difference in terms of the BIC ratios was found between the two groups. Conclusion: The results of this study demonstrate that DCS did not impair the BIC of the implants after four weeks of osseointegration. © 2020 Craniofacial Research Foundation
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    Guided bone regeneration with local zoledronic acid and titanium barrier: An experimental study
    (Spandidos Publications, 2016) Dundar S.; Ozgur C.; Yaman F.; Cakmak O.; Saybak A.; Ozercan I.H.; Alan H.
    The aim of this study was to evaluate the effects on new bone formation of autogenous blood alone or in combination with zoledronic acid (ZA), a ?-tricalcium phosphate (?-TCP) graft or ZA plus a ?-TCP graft placed under titanium barriers. For this purpose, eight adult male New Zealand white rabbits were used in the study, each with four titanium barriers fixed around four sets of nine holes drilled in the calvarial bones. The study included four groups, each containing 2 rabbits. In the autogenous blood (AB group), only autogeneous blood was placed under the titanium barriers. The three experimental groups were the AB+ZA group, with autogenous blood plus ZA, the AB+?-TCP group, with autogeneous blood plus a ?-TCP graft, and the AB+?-TCP+ZA group, with autogeneous blood plus a ?-TCP graft and ZA mixture under the titanium barriers. The animals were sacrificed after 3 months. The amounts of new bone formation identified histomorphometrically were found to be higher after 3 months than at the time of surgery in all groups. The differences between the groups were examined with histomorphometric analysis, and statistically significant differences were identified at the end of the 3 months. The bone formation rate in the AB+?-TCP+ZA group was determined to be significantly higher than that in the other groups (P<0.05). In the AB+ZA and AB+?-TCP groups, the bone formation rate was determined to be significantly higher than that in the AB group (P<0.05). No statistically significant difference in bone formation rate was observed between the AB+?-TCP and AB+ZA groups. Local ZA used with autogeneous blood and/or graft material appears to be a more effective method than the use of autogeneous blood or graft alone in bone augmentation executed with a titanium barrier. © 2016, Spandidos Publications. All rights reserved.