The effects of a nonsteroidal anti-inflammatory drug on the degree of titanium implant osseointegration
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study was to histologically examine the effects of a nonsteroidal anti-inflammatory drug, namely diclofenac sodium (DCS), on the extent of the bone–implant contact (BIC) of titanium implants after four weeks of osseointegration period in a rodent model. Material & methods: Fourteen female Sprague-Dawley rats were divided into two groups: the control (n = 7) and experimental (DCS) groups. Fourteen machine-surfaced titanium implants were placed in the right tibial bones of the rats. The DCS (2 mg/kg) was administered by means of oral gavage to the experimental group for 14 days after four weeks of osseointegration. No medication was administered to the control group throughout the six-week study period. At the end of the study, the rodents were sacrificed and block sections were obtained for histologic evaluation. Results: The mean BIC ratios for the control and DCS groups were 64.15 ± 6.31% and 61.10 ± 6.08%, respectively. No statistically significant difference in terms of the BIC ratios was found between the two groups. Conclusion: The results of this study demonstrate that DCS did not impair the BIC of the implants after four weeks of osseointegration. © 2020 Craniofacial Research Foundation
Açıklama
Anahtar Kelimeler
Bone implant connection, Diclofenac sodium, Nonsteroidal anti-inflammatory drug, Osseointegration
Kaynak
Journal of Oral Biology and Craniofacial Research
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
10
Sayı
4
