The effects of a nonsteroidal anti-inflammatory drug on the degree of titanium implant osseointegration

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dc.authorscopusid57191632156
dc.authorscopusid55653708100
dc.authorscopusid55317812800
dc.contributor.authorToy V.E.
dc.contributor.authorDundar S.
dc.contributor.authorBozoglan A.
dc.date.accessioned2024-08-04T20:03:38Z
dc.date.available2024-08-04T20:03:38Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to histologically examine the effects of a nonsteroidal anti-inflammatory drug, namely diclofenac sodium (DCS), on the extent of the bone–implant contact (BIC) of titanium implants after four weeks of osseointegration period in a rodent model. Material & methods: Fourteen female Sprague-Dawley rats were divided into two groups: the control (n = 7) and experimental (DCS) groups. Fourteen machine-surfaced titanium implants were placed in the right tibial bones of the rats. The DCS (2 mg/kg) was administered by means of oral gavage to the experimental group for 14 days after four weeks of osseointegration. No medication was administered to the control group throughout the six-week study period. At the end of the study, the rodents were sacrificed and block sections were obtained for histologic evaluation. Results: The mean BIC ratios for the control and DCS groups were 64.15 ± 6.31% and 61.10 ± 6.08%, respectively. No statistically significant difference in terms of the BIC ratios was found between the two groups. Conclusion: The results of this study demonstrate that DCS did not impair the BIC of the implants after four weeks of osseointegration. © 2020 Craniofacial Research Foundationen_US
dc.identifier.doi10.1016/j.jobcr.2020.06.006
dc.identifier.endpage336en_US
dc.identifier.issn2212-4268
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85087911576en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1016/j.jobcr.2020.06.006
dc.identifier.urihttps://hdl.handle.net/11616/91961
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Oral Biology and Craniofacial Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone implant connectionen_US
dc.subjectDiclofenac sodiumen_US
dc.subjectNonsteroidal anti-inflammatory drugen_US
dc.subjectOsseointegrationen_US
dc.titleThe effects of a nonsteroidal anti-inflammatory drug on the degree of titanium implant osseointegrationen_US
dc.typeArticleen_US

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