Yazar "Durak, Mehmet Akif" seçeneğine göre listele
Listeleniyor 1 - 20 / 37
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute subdural hematomas caused by ruptured aneurysms: Experience from a single turkish center(Turkish Neurosurgery, 2009) Koçak, Ayhan; Ateş, Özkan; Durak, Mehmet Akif; Alkan, Alpay; Çaylı, Süleyman; Saraç, KayaÖz: AMAÇ: Bir anevrizma ruptürü tipik olarak tomografide subaraknoid kanama ile ortaya çıkmasına rağmen kendiliğinden (travmasız) subdural kanama ile beraber görülebilir. Bu makalenin amacı, bu hayatı tehdit eden durumun klinik ve radyolojik özellikleriyle birlikte tanı ve tedavisindeki potansiyel tehlikeleri tartışmaktır. YÖNTEM ve GEREÇ: İnönü Üniversitesi Nöroşirürji Anabilimdalı (Turgut Özal Tıp Merkezi) 1999’dan bu yana intrakraniyal anevrizma tanısı ile tedavi edilen hastaların kayıtlarını prospektif olarak tutmaktadır. Bu veri tabanını kullanarak, tomografisinde akut subdural kanama ile gelen ruptüre anevrizma hastalarını tespit ettik. BULGULAR: Ocak 2000-Ocak 2009 tarihleri arasında radyolojik olarak dökümante edilmiş 687 hasta başvurdu. Bunların 11 (on bir) tanesinde akut travmatik olmayan subdural kanama mevcuttu. Akut subdural kanama-anevrizma rüptürü birlikteliği serimizde % 1,6 idi. SONUÇ: Subaraknoid kanamanın varlığı veya yokluğunda bile, tomografide görülen akut travmatik olmayan subdural kanama anevrizma ruptürü ile ilgili acil çalışmaları düşündürmelidir. CT anjiyografinin DSA’ya göre avantajları vardır ve akut olan bir travmatik olmayan subdural kanama olgularının tedavi planlaması, triyajı ve tanısında makul bir alternatif modalitedir.Öğe The beneficial effects of 18 glycyrrhetinic acid following oxidative and neuronal damage in brain tissue caused by global cerebral ischemia reperfusion in a C57BL J6 mouse model(Neurol Sci, 2014) Öztanır, Mustafa Namık; Çiftçi, Osman; Çetin, Aslı; Durak, Mehmet Akif; Başak, Neşe; Akyuva, YenerThis study investigated the effects of 18bglycyrrhetinic acid (GA) on neuronal damage in brain tissue caused by global cerebral ischemia/reperfusion (I/R) in C57BL/J6 mice. All subjects (n = 40) were equally divided into four groups: (1) sham-operated (SH), (2) I/R, (3) GA, and (4) GA?I/R. The SH group was used as a control. In the I/R group, the bilateral carotid arteries were clipped for 15 min, and the mice were treated with the vehicle for 10 days. In the GA group, mice were given GA (100 mg/ kg) for 10 days following a median incision without carotid occlusion. In the GA?I/R group, the I/R model was applied to the mice exactly as in the I/R group, and they were then treated with the same dose of GA for 10 days. Cerebral I/R significantly induced oxidative stress via an increase in lipid peroxidaitons and a decrease in elements of the antioxidant defense systems. However, GA treatment was protective against the oxidative effects of I/R by inducing significant increases in antioxidant defense systems and a significant decrease of lipid peroxidations. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by GA treatment. Therefore, the current study demonstrated that GA treatment effectively prevents oxidative and histological damage in the brain caused by global I/R. In this context, GA may be useful for the attenuation of the negative effects of global cerebral I/R and, in the future, it may be a viable and safe alternative treatment for ischemic stroke in humans.Öğe Chrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse model(Turkısh journal of medıcal scıences, 2016) Durak, Mehmet Akif; Öztanır, Mustafa Namık; Türkmen, Neşe Başak; Çiftçi, Osman; Taşlıdere, Aslı; Tecellioğlu, Mehmet; Önder, ArifThe present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group bilateral carotid arteries were clipped for 15 min and the mice were also treated with CRS (50 mg/kg) for 10 days. All of the rats were sacrificed under anesthesia on day 10, and neurodegenerative histological changes in the brain and tissue levels of oxidants and antioxidants were evaluated. Results: CRS treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathologies. In the CRS + I/R group, the decrease in TBARS levels and increase in GSH levels were similar to those in the SH group. Conclusion: Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.Öğe Clinical analysis of the cancer patients who admitted to the emergency room(Scientific Publishers India, 2016) Gurbuz, Sukru; Turtay, Muhammet Gokhan; Oguzturk, Hakan; Guven, Taner; Gur, Ali; Colak, Cemil; Durak, Mehmet AkifObjective: Patients with cancer diagnosis often admit to emergency room with complaints that are directly or indirectly related to their current condition. We aimed to analyze what complaints the cancer patients admit with most, how long the cancer patients who are treated with antitumor treatment admit to the emergency room after the antitumor treatment, which departments were consulted with these patients most and the outcomes of these patients in the emergency room. Method: In this study, 1946 male and female patients older than 18 years old with oncological diseases who admitted to the emergency room for any complaints were analyzed retrospectively. Results: 879 (45.2%) of the patients were females and 1067 (54.8%) of them were males. The mean age was 59.1. The most common complaint was abdominal pain with 344 (17.7%) patients. The most common malignancy was lung cancer with 335 (17.3%) patients. 610 (31.3%) of the patients in the study were still receiving chemotherapy whereas 1052 (54%) of the patients never had chemotherapy. 285 (14.6%) patients were not receiving chemotherapy although they previously had. It was found that the patients admitted to the emergency room a mean of 69.9 days after the chemotherapy. 651 (33.5%) of the patients were not consulted with any departments whereas other patients were consulted with other departments, with medical oncology being the most consulted department. 1017 (52.2%) patients were discharged from the emergency room and 895 (46%) patients were hospitalized. 33 patients (1.7%) died in the emergency room. Conclusions: Patients with lung cancer admitted to the emergency rooms more often. Cancer patients admitted to the emergency department with abdominal pain and shortness of breath most. Emergency physicians have increased responsibility for tests, treatment and hospitalization of these patients as the patients are generally older and have multiple conditions.Öğe Clinical analysis of the cancer patients who admitted to the emergency room(BIOMEDICAL RESEARCH-INDIA, 2016) Gürbüz, Şükrü; Turtay, Gökhan; Ögüztürk, Hakan; Güven, Taner; Gür, Ali; Çolak, Cemil; Durak, Mehmet AkifObjective: Patients with cancer diagnosis often admit to emergency room with complaints that are directly or indirectly related to their current condition. We aimed to analyze what complaints the cancer patients admit with most, how long the cancer patients who are treated with antitumor treatment admit to the emergency room after the antitumor treatment, which departments were consulted with these patients most and the outcomes of these patients in the emergency room. Method: In this study, 1946 male and female patients older than 18 years old with oncological diseases who admitted to the emergency room for any complaints were analyzed retrospectively. Results: 879 (45.2%) of the patients were females and 1067 (54.8%) of them were males. The mean age was 59.1. The most common complaint was abdominal pain with 344 (17.7%) patients. The most common malignancy was lung cancer with 335 (17.3%) patients. 610 (31.3%) of the patients in the study were still receiving chemotherapy whereas 1052 (54%) of the patients never had chemotherapy. 285 (14.6%) patients were not receiving chemotherapy although they previously had. It was found that the patients admitted to the emergency room a mean of 69.9 days after the chemotherapy. 651 (33.5%) of the patients were not consulted with any departments whereas other patients were consulted with other departments, with medical oncology being the most consulted department. 1017 (52.2%) patients were discharged from the emergency room and 895 (46%) patients were hospitalized. 33 patients (1.7%) died in the emergency room. Conclusions: Patients with lung cancer admitted to the emergency rooms more often. Cancer patients admitted to the emergency department with abdominal pain and shortness of breath most. Emergency physicians have increased responsibility for tests, treatment and hospitalization of these patients as the patients are generally older and have multiple conditions. Keywords Cancer, Emergency room, Oncology. Introduction Death caused by cancer is the second most common reason after cardiovascular causes in our country, Turkey. With the increase in older population, an increase in new cancer cases and side effects of cancer treatment are expected [1]. This increase affects emergency rooms as well as oncology departments in terms of volume and work force. Cancer patients can admit to emergency rooms for complaints caused by their condition like pain, bleeding and respiratory distress as well as the metabolic, infectious and endocrine problems caused by their condition. In addition to this, these patients can admit for febrile neutropenia or hypersensitivity reactions caused by antitumor medication administered for their treatment, or malnutrition or lack of care caused by inadequacy of social conditions. They also can admit to the hospital for trauma, cardiovascular diseases, pulmonary diseases and other conditions that are not caused by cancer [2,3]. Usually, the benefits of emergency rooms to the cancer patients are more than expected. We aimed to analyze what complaints the cancer patients admit with most, how long the cancer patients who are treated with antitumor treatment admit to the emergency room after the antitumor treatment, which departments were consulted with these patients most and the outcomes of these patients in the emergency room in a period of one year.Öğe Clinical analysis of the cancer patients who admitted to the emergency room(Biomedical research-India, 2016) Gürbüz, Şükrü; Turtay, Muhammet Gökhan; Oğuztürk, Hakan; Güven, Taner; Gür, Ali; Çolak, Cemil; Durak, Mehmet AkifObjective: Patients with cancer diagnosis often admit to emergency room with complaints that are directly or indirectly related to their current condition. We aimed to analyze what complaints the cancer patients admit with most, how long the cancer patients who are treated with antitumor treatment admit to the emergency room after the antitumor treatment, which departments were consulted with these patients most and the outcomes of these patients in the emergency room. Method: In this study, 1946 male and female patients older than 18 years old with oncological diseases who admitted to the emergency room for any complaints were analyzed retrospectively. Results: 879 (45.2%) of the patients were females and 1067 (54.8%) of them were males. The mean age was 59.1. The most common complaint was abdominal pain with 344 (17.7%) patients. The most common malignancy was lung cancer with 335 (17.3%) patients. 610 (31.3%) of the patients in the study were still receiving chemotherapy whereas 1052 (54%) of the patients never had chemotherapy. 285 (14.6%) patients were not receiving chemotherapy although they previously had. It was found that the patients admitted to the emergency room a mean of 69.9 days after the chemotherapy. 651 (33.5%) of the patients were not consulted with any departments whereas other patients were consulted with other departments, with medical oncology being the most consulted department. 1017 (52.2%) patients were discharged from the emergency room and 895 (46%) patients were hospitalized. 33 patients (1.7%) died in the emergency room. Conclusions: Patients with lung cancer admitted to the emergency rooms more often. Cancer patients admitted to the emergency department with abdominal pain and shortness of breath most. Emergency physicians have increased responsibility for tests, treatment and hospitalization of these patients as the patients are generally older and have multiple conditions.Öğe Comparison of the effects of PRP and hyaluronic acid in promoting peripheral nerve regeneration An experimental study with vascular conduit model in rats'(Edizioni Luigi Pozzi, 2016) Firat, Cemal; Aytekin, Ahmet Hamdi; Durak, Mehmet Akif; Geyik, Yilmaz; Erbatur, Serkan; Dogan, Metin; Elmas, OmerAIM: Peripheral nerve defects generally occur due to mechanical, chemical, thermal and pathologic causes and the reconstruction is still a challenging problem. In the present study, we aimed to compare the effects of platelet rich plasma (PRP) that has high levels of growth factors and hyaluronic acid (HA) that is known to have positive effects on nerve regeneration by decreasing scar formation in a rat model where they were injected through allogeneic aorta graft in peripheral nerve defects using histopathologic and functional methods. MATERIAL AND METHODS: The study involved 20 Wistar Albino male rats that weighed 200 to 250 grams and aged about 1 year old. Of the rats, two were used as donor for PRP and aorta graft harvest. Three random groups of 6 rats were composed. In all of the groups, the left sciatic nerves were used and 1 cm of defects were created. The right sciatic nerves were used as control groups. Group I was the group repaired with autograft, Group 2 was the group repaired with HA injected through aorta graft and Group 3 was the group repaired with PRP injected through aorta graft. The findings were evaluated in terms of functional (electromyography and walk test analysis) and histopathologic parameters at 12 weeks. RESULTS: In all of the groups varying degrees of axonal regeneration was observed. Group I was the closest group to the control group showing highest rate of nerve regeneration followed by Group 3 where PRP was injected through aorta graft and group 2 where ha was used respectively. CONCLUSION: The study demonstrates that PRP enhances peripheral nerve regeneration more than HA when used in a vascular conduit model.Öğe Concurrence of polyostotic fibrous dysplasia and spinal aspergillus in non-immunocompromised adult patient(2017) Akatlı, Ayşe Nur; Yıldırım, İsmail Okan; Durak, Mehmet Akif; Aladag, Mehmet Arif; Pasahan, RamazanAspergillus, a rare agent in spinal infections, is often transmitted via inhalation. It can be traced as an infectious agent in immunocompromised patients. While in non-immunocompromised patients, it is highly unlikely to cause spondylodiscitis. Radiological findings remind tuberculosis. The recommended medical treatment is applied with Itraconazole and Amphotericin B. Surgical indication involves the presence of progressive neurological deficit, instability and biopsy requirement. Fibrous dysplasia was first reported in 1938 by Lichtenstein and is a benign developmental disorder of the skeletal system with uncertain etiology. Polyostotic type involved more than one bone, while the monostotic type occurs by involving only one bone structure. Spinal involvement may lead to collapse fractures and deformity development and the most common complaint is pain.In our case, these two disorders occur concurrently, causing bone destruction and severe pain, and no similar cases were found in the literature.Öğe Concurrence of polyostotic fibrous dysplasia and spinal aspergillus in non-immunocompromised adult patient: Case report(Inonu University Faculty of Medicine Department of Neurosurgery, Malatya, Turkey, 2017) Pasahan, Ramazan; Durak, Mehmet Akif; Aladag, Mehmet Arif; Akatli, Ayşe Nur; Yildirim, Ismail OkanÖz: Aspergillus, a rare agent in spinal infections, is often transmitted via inhalation. It can be traced as an infectious agent in immuno- compromised patients. While in non-immunocompromised patients, it is highly unlikely to cause spondylodiscitis. Radiological find- ings remind tuberculosis. The recommended medical treatment is applied with Itraconazole and Amphotericin B. Surgical indication involves the presence of progressive neurological deficit, instability and biopsy requirement. Fibrous dysplasia was first reported in 1938 by Lichtenstein and is a benign developmental disorder of the skeletal system with uncertain etiology. Polyostotic type involved more than one bone, while the monostotic type occurs by involving only one bone structure. Spinal involvement may lead to collapse fractures and deformity development and the most common complaint is pain. In our case, these two disorders occur concurrently, causing bone destruction and severe pain, and no similar cases were found in the literature.Öğe Concurrence of polyostotic fibrous dysplasia and spinal aspergillus in non-immunocompromised adult patient:case report(2017) Pasahan, Ramazan; Durak, Mehmet Akif; Aladag, Mehmet Arif; Akatli, Ayşe Nur; Yildirim, Ismail OkanAspergillus, a rare agent in spinal infections, is often transmitted via inhalation. It can be traced as an infectious agent in immunocompromised patients. While in non-immunocompromised patients, it is highly unlikely to cause spondylodiscitis. Radiological findings remind tuberculosis. The recommended medical treatment is applied with Itraconazole and Amphotericin B. Surgical indication involves the presence of progressive neurological deficit, instability and biopsy requirement. Fibrous dysplasia was first reported in 1938 by Lichtenstein and is a benign developmental disorder of the skeletal system with uncertain etiology. Polyostotic type involved more than one bone, while the monostotic type occurs by involving only one bone structure. Spinal involvement may lead to collapse fractures and deformity development and the most common complaint is pain. In our case, these two disorders occur concurrently, causing bone destruction and severe pain, and no similar cases were found in the literature.Öğe Congenital Agenesis of Right Internal Carotid Artery: A Report of Two Cases(Ubiquity Press Ltd, 2016) Kahraman, Aysegul Sagir; Kahraman, Bayram; Ozdemir, Zeynep Maras; Dogan, Metin; Kaya, Mehmet; Gormeli, Cemile Ayse; Durak, Mehmet AkifCongenital unilateral agenesis of the internal carotid artery (ICA) is a rare anomaly. Due to proper sufficient collateral circulation via the circle of Willis most cases are asymptomatic, but patients can also present with ischemic or hemorrhagic cerebrovascular insults. The absence of the bony carotid canal is essential to differentiate this anomaly from chronic ICA occlusion. Awareness of this situation by clinicians and radiologists is essential because these patients have an increased incidence of various intracranial pathologies. We report two cases of this rare developmental congenital abnormality occurring in two young patients and describe the presentation, diagnosis, determined developmental causes, imaging findings, and complications.Öğe Detailed anatomical analysis of the sphenoid sinus and sphenoid sinus ostium by cone beam computed tomography(Journal of Craniofacial Surgery, 2016) Yılmaz, Nesibe; Köse,Evren; Dedeoğlu, Numan; Çolak, Cemil; Özbağ, Davut; Durak, Mehmet AkifAbstract: The aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. The authors’ study was performed using the cone-beam computed tomography images of 16 to 82-year old 200 (112 female, 88 male) patients (Newton 5G, Verona, Italy). Septum deviation of sphenoid sinus and the distance between 2 ostia were evaluated by coronal and axial sections, respectively. Pneumatization degree of sphenoid sinus, diameter of sphenoid sinus ostium, and distance lower edge of superior turbinate to sphenoid sinus ostium were measured by using sagittal sections. The sellar type was the most common pneumatization type of sphenoid sinus in authors’ study. While the C-type septum deviation was observed as the most common, T-type deviation was the least type. Sphenoid sinus ostium was bilaterally in 71.5% of individuals, and it was not found in 10% of individuals included in the study. A significant decrease was determined in diameter of the left sphenoid sinus ostium with aging. The distances between 2 sphenoid sinus ostia were 7.30 2.77 mm for women and 6.09 2.58 mm for men, respectively. No statistical differences were found in women and men in terms of distances between the lower edge of the right and left superior turbinate and sphenoid sinus ostium on their sides. Consequently, making detailed preoperative radiological evaluation of anatomic variations of sphenoid sinus and sphenoid sinus ostium is important in terms of guiding the surgeon in the process of a successful transsphenoidal surgery.Öğe Detailed anatomical analysis of the sphenoid sinus and sphenoid sinus ostium by cone beam computed tomography(Journal of Craniofacial Surgery, 2016) Yılmaz, Nesibe; Dedeoğlu, Numan; Çolak, Cemil; Özbağ, Davut; Durak, Mehmet AkifThe aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. The authors’ study was performed using the cone-beam computed tomography images of 16 to 82-year old 200 (112 female, 88 male) patients (Newton 5G, Verona, Italy). Septum deviation of sphenoid sinus and the distance between 2 ostia were evaluated by coronal and axial sections, respectively. Pneumatization degree of sphenoid sinus, diameter of sphenoid sinus ostium, and distance lower edge of superior turbinate to sphenoid sinus ostium were measured by using sagittal sections. The sellar type was the most common pneumatization type of sphenoid sinus in authors’ study. While the C-type septum deviation was observed as the most common, T-type deviation was the least type. Sphenoid sinus ostium was bilaterally in 71.5% of individuals, and it was not found in 10% of individuals included in the study. A significant decrease was determined in diameter of the left sphenoid sinus ostium with aging. The distances between 2 sphenoid sinus ostia were 7.30 2.77 mm for women and 6.09 2.58 mm for men, respectively. No statistical differences were found in women and men in terms of distances between the lower edge of the right and left superior turbinate and sphenoid sinus ostium on their sides. Consequently, making detailed preoperative radiological evaluation of anatomic variations of sphenoid sinus and sphenoid sinus ostium is important in terms of guiding the surgeon in the process of a successful transsphenoidal surgery. Key Words: Cone-beam computed tomography, sphenoid sinus, sphenoid sinus ostium, transsphenoidal surgery The sphenoid sinus is a double sinus located within the body of the sphenoid bone. Sizes, shapes, and pneumatization type vary from person to person. The bony septum that is located in the midline separates the 2 sinuses from each other.1 The sinus was surrounded with many important anatomical structures, neighborhoods internal carotid artery in the lateral wall, optic nerve at the superolateral and pterygoid nerve (The Vidian Nerve) at the base of the spheoid sinus.2 This sinus opens sphenoethmoidal recess by sphenoid sinus ostium that is located in the upper part of the front wall through the sphenoid sinus.3 The diameter of sphenoid sinus ostium is 2 to 3 mm, it is situated 11 to 14 mm above the base level of the sinus, 4 to 5 mm in lateral of nasal septum, 30 degrees above the base of the nose.4–6 The opening of sphenoid sinus ostium is one of the most important points in transsphenoidal surgery for surgeons. The surgical procedure is done by extending this opening. Closed or being in different positions of this opening can cause difficulty during surgical procedures.7 During the endoscopic and surgical transsphenoidal approaches, finding the ostium is not always easy. So the detection of detailed anatomical analysis this natural way and adjacent structures prior to transsphenoidal surgery may reduce complication incidence. The aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. At the same time, the anatomical variations and the pneumatization status of the sphenoid sinus were examined using the same method.Öğe Detailed Anatomical Analysis of the Sphenoid Sinus and Sphenoid Sinus Ostium by Cone-Beam Computed Tomography(Lippincott Williams & Wilkins, 2016) Yilmaz, Nesibe; Kose, Evren; Dedeoglu, Numan; Colak, Cemil; Ozbag, Davut; Durak, Mehmet AkifThe aim of this study is the evaluation of the anatomical structures of sphenoid sinus ostium used as a reference point for transsphenoidal surgery by cone beam computed tomography. The authors' study was performed using the cone-beam computed tomography images of 16 to 82-year old 200 (112 female, 88 male) patients (Newton 5G, Verona, Italy). Septum deviation of sphenoid sinus and the distance between 2 ostia were evaluated by coronal and axial sections, respectively. Pneumatization degree of sphenoid sinus, diameter of sphenoid sinus ostium, and distance lower edge of superior turbinate to sphenoid sinus ostium were measured by using sagittal sections. The sellar type was the most common pneumatization type of sphenoid sinus in authors' study. While the C-type septum deviation was observed as the most common, T-type deviation was the least type. Sphenoid sinus ostium was bilaterally in 71.5% of individuals, and it was not found in 10% of individuals included in the study. A significant decrease was determined in diameter of the left sphenoid sinus ostium with aging. The distances between 2 sphenoid sinus ostia were 7.30 +/- 2.77mm for women and 6.09 +/- 2.58mm for men, respectively. No statistical differences were found in women and men in terms of distances between the lower edge of the right and left superior turbinate and sphenoid sinus ostium on their sides. Consequently, making detailed preoperative radiological evaluation of anatomic variations of sphenoid sinus and sphenoid sinus ostium is important in terms of guiding the surgeon in the process of a successful transsphenoidal surgery.Öğe Effectiveness of Diffusion Tensor Imaging in Determining Cervical Spondylotic Myelopathy(Turkish Neurosurgical Soc, 2021) Er Ulubaba, Hilal; Saglik, Semih; Yildirim, Ismail Okan; Durak, Mehmet AkifAIM: To determine the effectiveness of diffusion tensor imaging (DTI) in diagnosing cervical spondylotic myelopathy (CSM) in patients with no findings detected in conventional magnetic resonance imaging (MRI). MATERIAL and METHODS: Fifty-four patients who presented for cervical MRI between January 2016 and June 2016, with symptoms such as neck pain, paresis, and numbness in hands, were included in the study. The patients were split into four groups based on their degrees of spinal stenosis. The obtained data were examined using special software and color-coded fractional anisotropy (FA), and apparent diffusion coefficient (ADC) maps were formed. Through these maps, using regions of interest (ROIs), FA and ADC values were calculated and the contribution of these values to the diagnosis was evaluated statistically. RESULTS: When all grades of cervical spinal canal stenosis were compared, a statistically significant negative correlation between spinal canal stenosis degree and FA values, and a positive correlation between stenosis degree and ADC values were noted (p<0.001). In the comparison of stenotic levels and non-stenotic levels for the grade 2 patient group, there was a statistically significant decrease in FA values and an increase in ADC values in stenotic levels compared with prestenotic and poststenotic levels (p<0.05). CONCLUSION: DTI and quantitative FA and ADC measurements are candidate imaging techniques for the diagnosis of early-stage CSM, which shows no findings in conventional MRI, and determining the degree of spinal cord injury.Öğe Effects of apocynin on sciatic nerve injury in rabbits(Taylor & Francis Ltd, 2023) Durak, Mehmet Akif; Ozhan, Onural; Tetik, Bora; Yildiz, Azibe; Aksungur, Zeynep; Vardi, Nigar; Turkoz, YusufWe investigated the effects of apocynin (APO) on experimental sciatic nerve compression injury in rabbits. We used 21 male rabbits divided randomly into three groups of seven. The control group was subjected to sciatic nerve compression with no further intervention. The APO treated group was subjected to compression injury and 20 mg/kg APO was administered daily for 21 days by intraperitoneal injection beginning the day after the injury. The sham group was treated with APO without injury. The control group exhibited shrinkage of axons, disruption of myelin sheaths and loss of nerve fibers. The damage for the control group was significantly greater than for the sham group. The severity of histopathology was decreased in the APO treated group compared to the control group, as was the oxidative stress index. Our findings suggest that APO treatment may contribute to healing of sciatic nerve damage.Öğe Effects of perineural administration of phenytoin in combination with levobupivacaine in a rat sciatic nerve block(Medicine Science, 2018) Özkan, Ahmet Selim; Akbaş, Sedat; Durak, Mehmet Akif; Erdoğan, Mehmet Ali; Parlakpınar, Hakan; Vardı, Nigar; Özer, AliÖz: Peripheral nerve blocks are commonly preferred worldwide for the purposes of anesthesia application and postoperative analgesia. In this study, we investigated the effects of phenytoin which has a similar mechanism to local anesthetics in terms of the duration of analgesia and quality. The study was performed on 32 Sprague-Dawley male rats. Rats were randomly grouped into 4 groups. Group S: Sham group (n: 8); 0,2 ml saline perineural unilateral sciatic nerve. Group L: Perineural levobupivacaine (0,2 ml 0,5% levobupivacaine, n: 8); Group Ph: Perineural phenytoin (0,2 ml 62,5 mg / kg, n: 8); Group L + PH: Perineural phenytoin and levobupivacaine (0,2 ml 0,5% levobupivacaine + 62,5 mg / kg phenytoin, n: 8). Hot-plate and tail- ?ick tests were performed to measure acute thermal pain and histological changes were evaluated. The latency time at 30 minute in Group L+Ph were significantly increased when compared to the other groups during evaluation of the hot plate test. There was a significant difference in terms of latency time at 30 minute in Group L+Ph in the Tail Flick test and the latency time in Group L+Ph was longer when compared to the other groups (p<0,05) These results were obtained according to hot-plate and tail-?ick tests and indicated that the analgesic quality. Perineural administration of phenytoin in combination with levobupivacaine did not affect the duration of the sensory and motor blockade at doses used in our study. However, phenytoin combined with levobupivacaine increased the duration and quality of the analgesia.Öğe Effects of Systemic Administration of Cisplatin and Hydrogen Sulfide on Cerebrum and Cerebellum Tissue in Rats(Karger, 2021) Polat, Seyhan; Ozhan, Onural; Parlakpinar, Hakan; Durak, Mehmet Akif; Vardi, Nigar; Yildiz, Azibe; Turkoz, Yusuf[Abstract Not Available]Öğe The Effects of Thymoquinone against Cisplatin-Induced Neurotoxic Rat Model(Karger, 2018) Durak, Mehmet Akif; Yildiz, Azibe; Ozhan, Onural; Parlakpinar, Hakan; Vardi, Nigar; Cigremis, Yilmaz; Tunc, Selahattin[Abstract Not Available]Öğe Efficiency of mechanical thrombectomy in acute ischemic stroke patients(2020) Kolu, Mehmet; Yıldırım, İsmail Okan; Turan Kaya, Ahmet; Kamışlı, Suat; Kaplan, Yüksel; Durak, Mehmet Akif; Gürbüz, Şükrü; Saraç, KayaAbstract: The aim of this single-center study is to assess the outcomes in patients with acute ischemic stroke underwent endovascular mechanical thrombectomy. The data and outcome of patients who were admitted due to acute ischemic stroke caused by a large vessel occlusion in the anterior or posterior circulation and treated with endovascular stent retriever mechanical thrombectomy between 2014 and 2018 were retrospectively evaluated. Recanalization success was assessed based on Thrombolysis in Cerebral Infarction (TICI) scores, and the TICI grades 2b and 3 were considered as ‘successful’. Functional outcomes of the patients were assessed by modified Rankin Scale (mRS) at the 3rd month follow up and a score of ?2 points was considered as ‘good clinical outcome’. Successful recanalization was achieved in 34 patients (69%). At the 3rd month follow-up, 23 patients (46,9%) had mRS scores of ?2 points. The overall mortality rate at the 90th day was %30 (n=15). After endovascular thrombectomy, symptomatic intracranial hemorrhage was seen in 9 patients, groin hematoma due to vascular access in 5 patients, which did not require additional treatment, and pseudoaneurysm in 3 patients. Stent retriever mechanical thrombectomy is an effective and safe procedure in patients admitted due to acute ischemic stroke caused by large vessel occlusion.
