Chrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse model
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkısh journal of medıcal scıences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group bilateral carotid arteries were clipped for 15 min and the mice were also treated with CRS (50 mg/kg) for 10 days. All of the rats were sacrificed under anesthesia on day 10, and neurodegenerative histological changes in the brain and tissue levels of oxidants and antioxidants were evaluated. Results: CRS treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathologies. In the CRS + I/R group, the decrease in TBARS levels and increase in GSH levels were similar to those in the SH group. Conclusion: Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.
Açıklama
Anahtar Kelimeler
Chrysin, Neuroprotection, Global ischemia/reperfusion, C57 BL /J6 mice
Kaynak
Turkısh journal of medıcal scıences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
46
Sayı
6
Künye
Durak, M. A. Öztanır, M. N. Türkmen, N. B. Çiftçi, O. Taşlıdere, A. Tecellioğlu, M. Önder, A. (2016). Chrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse model. Turkısh journal of medıcal scıences. 46, 1926–1933.
