Chrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse model

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dc.authorid53917en_US
dc.contributor.authorDurak, Mehmet Akif
dc.contributor.authorÖztanır, Mustafa Namık
dc.contributor.authorTürkmen, Neşe Başak
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorTaşlıdere, Aslı
dc.contributor.authorTecellioğlu, Mehmet
dc.contributor.authorÖnder, Arif
dc.date.accessioned2017-06-27T11:39:39Z
dc.date.available2017-06-27T11:39:39Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group bilateral carotid arteries were clipped for 15 min and the mice were also treated with CRS (50 mg/kg) for 10 days. All of the rats were sacrificed under anesthesia on day 10, and neurodegenerative histological changes in the brain and tissue levels of oxidants and antioxidants were evaluated. Results: CRS treatment significantly reversed the oxidative effects of I/R and inhibited the development of neurodegenerative histopathologies. In the CRS + I/R group, the decrease in TBARS levels and increase in GSH levels were similar to those in the SH group. Conclusion: Treatment with CRS can positively affect the neural system of mice and it can be used for the treatment of global cerebral I/R.en_US
dc.identifier.citationDurak, M. A. Öztanır, M. N. Türkmen, N. B. Çiftçi, O. Taşlıdere, A. Tecellioğlu, M. Önder, A. (2016). Chrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse model. Turkısh journal of medıcal scıences. 46, 1926–1933.en_US
dc.identifier.doi10.3906/sag-1508-119en_US
dc.identifier.endpage1933en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid28081349en_US
dc.identifier.scopus2-s2.0-85006699902en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1926en_US
dc.identifier.trdizinid254904en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1508-119
dc.identifier.urihttps://hdl.handle.net/11616/7258
dc.identifier.urihttp://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=sag-1508-119
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/254904
dc.identifier.volume46en_US
dc.identifier.wosWOS:000393331000049en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkısh journal of medıcal scıencesen_US
dc.relation.ispartofTurkısh journal of medıcal scıencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChrysinen_US
dc.subjectNeuroprotectionen_US
dc.subjectGlobal ischemia/reperfusionen_US
dc.subjectC57 BL /J6 miceen_US
dc.titleChrysin prevents brain damage caused by global cerebralischemia reperfusion in a C57BL J6 mouse modelen_US
dc.typeArticleen_US

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