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Öğe Correlations between event-related potential components and nitric oxide in maximal anaerobic exercise among sportsmen trained at various levels(Taylor & Francis Ltd, 2005) Duzova, H; Özisik, HI; Polat, A; Emre, MH; Gullu, EPhysical exercise has influence on all organs except its effects oil the central nervous system have not been fully elucidated. This study attempts to determine whether the degree of training could affect the response to physical stress by comparing the three groups of males in different levels of the physical fitness. Serum samples from high (n = 11), moderate (n = 10), and low physical activity sportsmen (n = 10) were collected to determine nitrite/nitrate levels before and after carrying out an anaerobic maximal exercise test. All oddball paradigm of auditory stimuli was used to evoke the N200 and P300 before and after the exercise. The amplitude of the N200 decreased significantly after anaerobic maximal exercise compared to the values of the recorded pre-exercise at Fz area in high physical activity group. There was a negative correlation between event-related potentials component and both nitrite/mtrate serum level changes and the heart rate changes in low physical activity subjects. However. in high and moderate physical activity groups, these relationships were positive.Öğe Effects of training period on haemorheological variables in regularly trained footballers(Bmj Publishing Group, 2005) Karakoc, Y; Duzova, H; Polat, A; Emre, MH; Arabaci, IObjective: To investigate the effects of one football training period on haemorheological variables in regularly trained footballers. Method: Ten subjects were randomly selected from the reserve team of a football club in the Turkish Premier League. During the last week of the football season, one day before a standard training session and two days after the previous league match, venous blood samples were taken (pre-exercise). After 90 minutes of standard training, further blood samples were taken (post-exercise). Blood lactate, blood viscosity, plasma fibrinogen, blood clotting time, acid-base variables, and plasma Na+, K+, and Ca2+ were determined. Results: Haemoglobin, packed cell volume, and mean corpuscular volume were all significantly decreased, whereas white blood cells and platelets were both increased after training. Blood viscosity decreased but the reduction was not significant. Blood lactate, plasma glucose, and Na+ content were significantly increased, but standard bicarbonate, actual bicarbonate, and Ca2+ were significantly decreased. Blood clotting time had shortened significantly after training. Blood viscosity was inversely correlated with plasma glucose concentration (r = -0.48 and p = 0.032). Conclusions: The results show that blood viscosity tends to decrease as the result of this type of training. This is due to a reduction in packed cell volume and mean corpuscular volume. The increased blood lactate does not have an adverse effect on the blood of these subjects because protective mechanisms develop with regular training throughout the season.Öğe Neutrophil superoxide anion production, and CAT and GSSGR activity in patients with tuberculosis(Luigi Ponzio E Figlio, 2003) Düzova, H; Asma, D; Emre, MHTuberculosis (TB) is a chronic infection disease caused by Mycobacterium tuberculosis (MTB), as an intracellular pathogen. Various cytokines (TNF-alpha, IL's,GSF etc.) and other factors play important preventing roles and are secreted during the infection. It may cause changes in the metabolism of neutrophils. Production of superoxide anion and antioxidative enzymes activities, such as glutathione reductase (GSSGR) and catalase (CAT) may be changed during MTB infection in the host. In this study, the control group consisted of ten healthy subjects and ten patients with TB, were studied before anti-TB treatment. Level of superoxide anion production, activity of CAT and activity of GSSGR were studied from peripheral neutrophils of healthy subjects and patients with TB. Catalase activities of the neutrophils were significantly lower in patients with TB than normal subjects (p< 0.01). Glutathione reductase activities of the neutrophils were also significantly lower in patients with TB than normal subjects (p< 0.05). Superoxide anion production in the neutrophils did not show any significant difference between TB and normal subjects (p> 0.05). As a result, the activities of CAT and GSSGR were lower in the peripheral neutrophils of patients with TB than normal subjects, whereas superoxide anion production in the neutrophils did not differ between in TB patients than normal subjects.Öğe Protection from renal ischemia reperfusion injury by an endothelin a-receptor antagonist bq-123 in relation to nitric oxide production(Federation Amer Soc Exp Biol, 2005) Erdodan, H; Fadillioglu, E; Emre, MH[Abstract Not Available]Öğe Renal antioxidant status in rats with hypertension induced by N sup omega nitro-L-arginine methyl ester(Karger, 2002) Fadillioglu, E; Erdogan, H; Polat, A; Emre, MHNitric oxide (NO) has a role in the etiopathogenesis of hypertension. Relaxation of vascular smooth muscles is failed when NO production is reduced leading to increased vascular peripheral resistance. N sup omega nitro-L-arginine methyl ester (L-NAME) is one of the inhibitors of NO production. The aim of this study was to investigate oxidant-antioxidant systems of renal tissue in rats with hypertension induced by L-NAME. Rats were divided into three groups: control group and study groups treated with 100 or 500 mg/l L-NAME in drinking water for 15 days. The activities of catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), and the levels of malondialdehyde (MDA) and NO were studied in the renal tissue after hypertension induction. Arterial blood pressure was increased in both L-NAME groups. CAT activity of 500-mg L-NAME group was higher than control. GSH-Px activity of 500-mg L-NAME group was decreased compared with 100-mg ones. NO level was lower in 500-mg L-NAME group than control. MDA levels in both L-NAME groups were decreased compared with control. In conclusion, hypertension was induced with oral L-NAME treatment. Increased CAT activity was compensated with decreased GSH-Px activity in 500-mg L-NAME group. Both study groups were protected from lipid peroxidation with NO inhibition.Öğe Serum selenium response to maximal anaerobic exercise among sportsmen trained at various levels(Wiley-Liss, 2004) Emre, MH; Düzova, H; Sancak, B; Polat, A; Erdogan, H; Yologlu, SSerum selenium (Se) is a constitutional part of both major plasma selenoprotein P and glutathione peroxidase (GSH-Px), a cytoprotective enzyme against the oxidative damage. It is an accepted fact that any case related to oxidative stress increased by physical exercise changes serum Se levels. In this Study serum Se levels were examined in high physical activity (group I). moderate physical activity (group II), and low physical activity (group III) mates undertaking a soccer-training regimen. In addition, Se changes before and after the acute intensive maximal exercise in an anaerobicloading coordination tests among groups I, II, and III soccer players were investigated. For a minimum of 3 months, the players in group I (n = 12), exercising more than 5 It a week. group II (n = 9), exercising less than 5 h but more than 2 h a week, and group III (n = 11), exercising regularly or irregularly less than 2h were examined. Heart rate monitor 220 (heart rate)-age formula wits used to evaluate the maximal exercising test during the procedure. Serum Se was analyzed by atomic absorption spectrophotometry. The difference between groups before and after the exercise was tested by Wilcoxon test, and the difference varying in the groups was tested by Kruskal-Wallis variance analyse. The relation between heart rate and serum Se was tested by Sperman's rank correlation analyses. After maximal physical exercise, the serum selenium level decreased significantly compared with pre-exercise values (P < 0.05) in group I only. III group 1, maximal and pre-exercise heart rates as opposed to pre- and post-exercise serum Se level were negative correlated (P < 0.05). In conclusion, a nutrition regime rich in selenium may be beneficial for both athletes who exercise regularly and in patients with increasing oxidative stress. (C) 2004 Wiley-Liss. Inc.
