Neutrophil superoxide anion production, and CAT and GSSGR activity in patients with tuberculosis
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Luigi Ponzio E Figlio
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Tuberculosis (TB) is a chronic infection disease caused by Mycobacterium tuberculosis (MTB), as an intracellular pathogen. Various cytokines (TNF-alpha, IL's,GSF etc.) and other factors play important preventing roles and are secreted during the infection. It may cause changes in the metabolism of neutrophils. Production of superoxide anion and antioxidative enzymes activities, such as glutathione reductase (GSSGR) and catalase (CAT) may be changed during MTB infection in the host. In this study, the control group consisted of ten healthy subjects and ten patients with TB, were studied before anti-TB treatment. Level of superoxide anion production, activity of CAT and activity of GSSGR were studied from peripheral neutrophils of healthy subjects and patients with TB. Catalase activities of the neutrophils were significantly lower in patients with TB than normal subjects (p< 0.01). Glutathione reductase activities of the neutrophils were also significantly lower in patients with TB than normal subjects (p< 0.05). Superoxide anion production in the neutrophils did not show any significant difference between TB and normal subjects (p> 0.05). As a result, the activities of CAT and GSSGR were lower in the peripheral neutrophils of patients with TB than normal subjects, whereas superoxide anion production in the neutrophils did not differ between in TB patients than normal subjects.
Açıklama
Anahtar Kelimeler
neutrophils, superoxide anion, catalase, glutathione reductase, mycobacterium tuberculosis
Kaynak
Microbiologica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
26
Sayı
3
