Neutrophil superoxide anion production, and CAT and GSSGR activity in patients with tuberculosis

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dc.authoridAsma, Dilek/0000-0002-3866-3016
dc.authorwosidAsma, Dilek/AAA-5294-2021
dc.contributor.authorDüzova, H
dc.contributor.authorAsma, D
dc.contributor.authorEmre, MH
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTuberculosis (TB) is a chronic infection disease caused by Mycobacterium tuberculosis (MTB), as an intracellular pathogen. Various cytokines (TNF-alpha, IL's,GSF etc.) and other factors play important preventing roles and are secreted during the infection. It may cause changes in the metabolism of neutrophils. Production of superoxide anion and antioxidative enzymes activities, such as glutathione reductase (GSSGR) and catalase (CAT) may be changed during MTB infection in the host. In this study, the control group consisted of ten healthy subjects and ten patients with TB, were studied before anti-TB treatment. Level of superoxide anion production, activity of CAT and activity of GSSGR were studied from peripheral neutrophils of healthy subjects and patients with TB. Catalase activities of the neutrophils were significantly lower in patients with TB than normal subjects (p< 0.01). Glutathione reductase activities of the neutrophils were also significantly lower in patients with TB than normal subjects (p< 0.05). Superoxide anion production in the neutrophils did not show any significant difference between TB and normal subjects (p> 0.05). As a result, the activities of CAT and GSSGR were lower in the peripheral neutrophils of patients with TB than normal subjects, whereas superoxide anion production in the neutrophils did not differ between in TB patients than normal subjects.en_US
dc.identifier.endpage298en_US
dc.identifier.issn1121-7138
dc.identifier.issue3en_US
dc.identifier.pmid12901426en_US
dc.identifier.scopus2-s2.0-0141939525en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://hdl.handle.net/11616/93633
dc.identifier.volume26en_US
dc.identifier.wosWOS:000184437500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLuigi Ponzio E Figlioen_US
dc.relation.ispartofMicrobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneutrophilsen_US
dc.subjectsuperoxide anionen_US
dc.subjectcatalaseen_US
dc.subjectglutathione reductaseen_US
dc.subjectmycobacterium tuberculosisen_US
dc.titleNeutrophil superoxide anion production, and CAT and GSSGR activity in patients with tuberculosisen_US
dc.typeArticleen_US

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