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The Alterations of the Anterior Chamber Parameters Measured with Pentacam with Age in Healthy Subjects
(Turkish Ophthalmological Soc, 2008) Emre, Sinan; Koc, Bekir; Doganay, Selim; Yologlu, Saim
Purpose: To determine the mean values and standard deviations of anterior chamber parameters with pentacam and evaluate the alterations of these parameters with age. Material-Method: 224 eyes of 112 patients with just basic refractive errors were included in this study. After complete ophthalmologic examination of patients, under standard conditions anterior chamber parameters were measured with pentacam. Central corneal thickness (CCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber volume (ACV), anterior chamber angle (ACA), and also horizontal, vertical and mean keratometry values were recorded with pentacam. Results: 55 female and 57 male patients were included in this study. Mean age of patients was 28.57. Mean of the keratometric measurements was 43.1 D. Mean values for CCT, ACD, CV, ACV and ACA were 534 mu m, 3.14 mm, 59.77 mm(3), 190.26 mm(3), 36.88 degrees, respectively. Evaluation of parameters according to gender and eye distribution did not reveale any difference. Analysis the effect of age on CCT, ACD, CV, ACV and ACA parameters documented statistical significance (p< 0.005) and correlation coefficents were r=-0.185, -0.373, -0.263, -0.320, -0.264, respectively. Conclusion: This study documented the negative effect of age on the anterior chamber parameters with different correlation coefficients.
Bilateral Aniridia Lenticular Coloboma and Snowflake Retinal Degeneration
(Slack Inc, 2009) Doganay, Selim; Emre, Sinan; Firat, Penpeguel
A 6-year-old boy presented with bilateral aniridia associated with lens coloboma and snowflake retinal degeneration. Ophthalmologic examination revealed bilateral corneal peripheral epithelial thickening and aniridia. Additionally, the patient had lenticular coloboma and snowflake retinal degeneration in both eyes. Intraocular pressure was 22 mm Hg bilaterally. The patient also had pendular nystagmus. Uncorrected visual acuity was counting fingers at 2 meters for both eyes, but improved to 0.2 and 0.05, respectively, with correction. Congenital aniridia has been reported with various ophthalmic pathologies, but this is the first case to display bilateral lenticular coloboma and snowflake retinal degeneration associated with aniridia. [Ophthalmic Surg Lasers Imaging 2009;40:54-56.]
Bir çocuk olguda idiopatik orbital miyozit
(2008) Türkçüoğlu, Peykan; Emre, Sinan; Fırat, Ahmet; Bilak, Şemsettin
Öz: Onbeş yaşında kız hasta, beş gün önce başlayan yukarı bakışta çift görme şikayeti ile kliniğimize başvurdu. Hastanın göz hareket muayenesinde yukarı bakışta hareket kısıtlılığı tespit edildi. Orbital miyozit, tiroid oftalmopati ön tanıları ile orbital manyetik rezonans görüntüleme (MRG) tetkiki istendi ve sol alt rektus kasın tendonu ile birlikte düzensiz tutulduğu görüldü. Tiroid hormon testlerinin normal sınırlarda olması ve MRG bulguları ile, hastaya idiopatik orbital miyozit tanısı konarak 60 mg/gün oral fluokortolon tedavisi başlandı. Birinci ayın sonunda yukarı bakış kısıtlılığının ve çift görme şikayetinin kalmaması nedeni ile iki hafta içinde ilaç dozu azaltılarak kesildi.
Comparison of the Protective Effects of Prostaglandin Analogues in the Ischemia and Reperfusion Model of Rabbit Eyes
(Int Press Editing Centre Inc, 2009) Emre, Sinan; Gul, Mehmet; Ates, Burhan; Esrefoglu, Mukaddes; Koc, Bekir; Erdogan, Ali; Yesilada, Elif
This study was planned to investigate the neuroprotective potentials of three commercially available prostaglandin analogues (PGA), in the ischemia and reperfusion model (I/R). Thirty New Zealand rabbits were divided into 5 groups and except for the control group (non-ischemic, non-treated), 0.9% NaCl, bimatoprost, latanoprost, or travoprost were applied to both eyes of animals of the respective groups for 1 week. At the end of treatment, ischemia was induced in both eyes of the 4 treatment groups by anterior chamber irrigation of the animals for 60 min. Following 24 h reperfusion, the animals were sacrified. Enucleated eyes and retinal tissues were investigated by light microscopy, electron microscopy, immunohistochemicstry for retinal histopathology, intracellular and apoptotic cells and by retinal morphometry. Vitreous samples were biochemically investigated for probable role of reactive oxygen species, by measuring xanthine oxidase (XO) activity. Analysis of morphometric measurements and vitreous XO activity revealed significant differences between the PGA-treated groups and the NaCl-treated group (P<0.05). Similarly, apoptotic cell counts in different retinal layers showed that PGA-treated groups had fewer apoptotic cells in all retinal layers than the NaCl-treated ischemic group (P<0.05). PGA may have high protective potential for different retinal layers and cells. Biochemical analysis of vitreous showed that all PGAs decreased vitreous XO activity significantly compared to the NaCl-treated group (P<0.05). However we could not find any statistically significant differences among the analogues. PGAs may reduce the injury induced by I/R, through the inhibition of XO activity, and it seems that their effects are elicited through numerous pathways.
Conducting polymers with benzothiadiazole and benzoselenadiazole units for biosensor applications
(Elsevier Science Sa, 2011) Emre, Fatma Bilge; Ekiz, Fulya; Balan, Abidin; Emre, Sinan; Timur, Suna; Toppare, Levent
Poly(4,7-di(2,3)-dihydrothienol[3,4-b][1,4]dioxin-5-yl-benzo[1,2,5]thiadiazole) (PBDT) and poly(4,7-di(2,3)-dihydrothienol[3,4-b][1,4]dioxin-5-yl-2,1,3-benzoselenadiazole) (PESeE) were electrochemically deposited on graphite electrodes and used as immobilization matrices for biosensing studies. After electrochemical deposition of the polymeric matrices, glucose oxidase (GOx) was immobilized on the modified electrodes as the model enzyme. In the biosensing studies, the decrease in oxygen level as a result of enzymatic reaction was monitored at -0.7 V vs Ag/AgCl (3.0 M KCl) and correlated with substrate concentration. The biosensor was characterized in terms of several parameters such as operational and storage stabilities, kinetic parameters (K-m and I-max) and surface morphologies. The biosensor was tested on real human blood serum samples. (C) 2011 Elsevier B.V. All rights reserved.
Diyabet Hastalarının Lens Ön Kapsüllerinde Glutatyon Seviyesi ve Glutatyon Peroksidaz Aktivitesi
(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2008) Emre, Sinan; Ateş, Burhan; Taşar, Ahmet; Doğanay, Selim
Amaç: Bu çalışmada yaşa bağlı kataraktı bulunan hastalar ile sıkı kontrol altındaki diabet hastalarının lens ön kapsüllerinde ölçülen glutatyon (GSH) seviyesi ve glutatyon peroksidaz (GSH-Px) aktiviteleri değerlendirilmiştir. Yöntem: Çalışmaya tip II diabeti ve kataraktı bulunan hastalar ile yaş uyumlu olacak şekilde yaşa bağlı kataraktı bulunan hastalar dahil edildiler. Çalışma kapsamında sıkı diabet kontrolünde olan 18 hasta ile (Grup A), yaşa bağlı kataraktı bulunan 26 hastanın (Grup B) fakoemulsifikasyon yöntemi ile yapılan katarakt operasyonlarında alınan lens ön kapsülleri dahil edilmiştir. Örnekler çözünüp, santrifüje edilmelerinden sonra numunelerden GSH seviyeleri ve GSH-Px enzim aktiviteleri ölçülmüştür. Sonuçlar: Grup A ortalama yaşları 60.3 ± 8.3 yıl olan, 10 bayan ve 8 erkek hastadan oluşmaktaydı. Grup B ise ortalama yaşları 63.9 ± 12.2 yıl olan, 11 bayan ve 15 erkek hastadan oluşmaktaydı. Grup A ve B için lens ön kapsülünde ölçülen ortalama GSH seviyeleri sırasıyla 82.4±16.5 ve 97.5±12.5 nmol/mg iken ortalama GSH-Px aktivite düzeyleri sırasıyla 27.0±9.7 ve 36.9±9.3 mmol/mg protein idi. Her iki parametre içinde gruplar arasındaki fark istatistiksel olarak anlamlı düzeyde tespit edilmedi (p>0.05). Yorum: Diabetin anti-oksidan mekanizmalar üzerindeki zararlı etkisi iyi bilinmektedir. Bizim sonuçlarımızda GSH seviyesinin ve GSH-Px aktivitelerinin sıkı kontrollü diabet grubunda ve yaşa bağlı kataraktı grubu arasında yakın değerlerde çıkmış olması, diabetin sıkı kontrolünün diabetin lens üzerindeki etkilerini hafifletmek bakımından önemli olduğunu düşündürtmektedir.
Evaluation of anterior segment parameter changes using the Pentacam after uneventful phacoemulsification
(Wiley-Blackwell, 2010) Doganay, Selim; Bozgul Firat, Penpegul; Emre, Sinan; Yologlu, Saim
Purpose: This study set out to evaluate the influences of uneventful phacoemulsification on the anterior segment parameters obtained with the Pentacam rotating Scheimpflug camera and intraocular pressure (IOP). Methods: A total of 42 eyes of 34 patients (26 men, eight women) were evaluated preoperatively, and at 1, 3 and 6 months postoperatively with the Pentacam. Intraocular pressure was measured with the Goldmann applanation tonometer. The non-parametric paired t-test was used to compare preoperative and 1-, 3- and 6-month postoperative measurements of anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), the central 3-, 5- and 7-mm corneal volume (CV), pupil size, and IOP. Pearson's correlation test was used to evaluate the relationships between IOP and ACD, ACV and ACA width. Results: The differences between ACD, ACV, ACA and IOP values taken preoperatively and those taken postoperatively at 1, 3 and 6 months were statistically significant (p < 0.05). The differences between CCT, central 3-, 5- and 7-mm CV, and pupil size measurements taken preoperatively and those taken postoperatively at 1, 3 and 6 months were not statistically significant (p > 0.05). The decrease in IOP was not correlated with the changes in ACD, ACV and ACA (p > 0.05). Conclusions: Uneventful phacoemulsification significantly reduced IOP, increased ACD and ACV, and widened the ACA. However, alterations in CV, CCT and pupil size values were not statistically significant. Alterations in ACD, ACV, ACA and IOP remain stable after the first month of surgery.
Evaluation of anterior segment parameters in keratoconic eyes measured with the Pentacam system
(Elsevier Science Inc, 2007) Emre, Sinan; Doganay, Selim; Yologlu, Saim
PURPOSE: To evaluate the alteration in anterior chamber parameters with the progression of keratoconus using a rotating Scheimpflug camera. SETTING: Inonu University, Turgut Ozal Medical Center, Ophthalmology Department, Malatya, Turkey. METHODS: Two hundred sixteen eyes of 123 patients diagnosed with keratoconus and 224 eyes of 112 normal subjects were evaluated with a Pentacam Scheimpflug camera (Oculus Inc.). Keratoconic eyes were divided into 3 groups according to mean keratometer (K) readings: mild (K = less than 47.0 diopters [D]), moderate (K = 47.0 to 52.0 D), and severe (K = 52.0 D or higher). The following parameters were obtained: thinnest corneal thickness (TCT), anterior chamber depth (ACD), corneal volume (CV), anterior chamber angle (ACA), and anterior chamber volume (ACV). RESULTS: One hundred twenty-nine eyes had mild keratoconus, 59 had moderate keratoconus, and 35 had severe keratoconus. There were no statistically significant differences between the keratoconus group and control group in age, sex, or eye distribution (P>.05). With the progression of the disease, TCT and ACID were statistically different between all groups (P<.05). There were statistically significant differences in ACA and CV measurements between the mild keratoconus and severe keratoconus groups (P<.05). Also, CV readings were significantly different between the control group and all keratoconus groups (P<.05), although there was no significant difference in ACA measurements (P>.05). Despite a progressive increase in the ACV with disease progression, the differences between groups were not statistically significant (P>.05) except between the severe keratoconus group and the control group (P<.05). CONCLUSION: Anterior segment parameters of the eye showed significant alterations with the progression of keratoconus.
Incontinentia pigmenti: a case report and literature review
(Turkish J Pediatrics, 2009) Emre, Sinan; Firat, Yezdan; Gungor, Serdal; Firat, Ahmet Kemal; Karincaoglu, Yelda
Incontinentia pigmenti (IP) is a rare, X-linked dominant disorder that presents at or soon after birth with characteristic cutaneous signs. The eyes and central nervous system are the next most commonly affected systems. We aimed to describe the ophthalmological, neurological and radiodiagnostic findings of a patient with IP and bilateral retinal detachment. Clinical and laboratory findings of a four-month-old female baby who did not have light fixation and had neurological maturation retardation are presented. Characteristic skin lesions of IP were noted especially at the extremities, bilaterally. On neurological examination, motor and mental maturation were retarded and axial hypotonia was noted. Bilateral retinal detachment was the cause of absent eye fixation noted during ophthalmologic examination, and the detachments were also documented by ultrasonography and magnetic resonance imaging (MRI). Otologic examination was normal. Focal left frontal lobe atrophy, corpus callosum hypoplasia and prominence of right hemisphere were also noted on MRI. MR spectroscopy revealed negative lactate peak at the involved left frontal lobe. Bilateral retinal detachment is a probable finding in IP and patients with neurological symptoms should be investigated for associated sight- threatening ocular pathologies.
İnternal karotid arteri tam tıkalı olan bir olguda oküler iskemik sendrom
(Glokom Katarakt, 2009) Demirel, Soner; Fırat, Bozgül Pembegül; Doğanay, Selim; Koç, Bekir; Emre, Sinan
Öz: Amaç: Bu çalış manın amacı Revo-S ve self- adjusting file (SAF) ile preparasyonu yapılan eğ imli kök kanallarının lateral kompaksiyon (LK) ve termoplastik enjekte edilebilen (TPE) guta perka tekniklerinin kök kanal dolgu kalitesini dijital radyografi kullanarak değ erlendirmektir. Gereç ve Yöntem: Kırk adet eğ imli kök kanallarına sahip mandibular molar diş in mesial kök kanalları SAF veya Revo-S eğ e sistemleri ile prepare edildi. Kök kanal kurvatürü değ erlendirildikten sonra kanallar iki alt gruba bölündü (n=20, p >0.05). Hem mesiobukkal hem de mesiolingual kanallar geniş letildi ve AH Plus ile LK veya TPE guta perka dolgu teknikleriyle dolduruldu. Örnekler bir hafta boyunca patın sertleş mesi için 37 0C ve % 100 nemli ortamda bekletildi. Kanal dolgularını değ erlendirmek için çalış ma sonrası dijital radyografiler alındı. Veriler Mann-Whitney U testi ile analiz edildi. Bulgular: Preparasyon teknikleri açısından kök kanal dolgu teknikleri arasında önemli bir fark bulunmadı (p=0,051, p= 0,127). Sonuçlar: Bu çalış ma koş ulları altında kurvatürlü kanallarda, ne preparasyon tekniğ i ne de dolgu tekniğ i kök kanalı dolum kalitesini etkilememektedir. Başlık (İngilizce): The quality of different preparation and root canal filling techniques in curved root canals Öz (İngilizce): Objectives: The aim of this study was to evaluate the quality of different root canal filling techniques that lateral compaction (LC) and thermoplasticized injectable (TPE) gutta percha in curved root canals which were prepared Revo-S or self-adjusting file (SAF) using digital radiographs. Materials and Methods: Fourty extracted mandibular molar of mesial canals of teeth which have curved root canals were prepared using SAF or Revo-S instruments. After determination of root canal curvatures in two directions, the canals were divided two subgroups (n=20, p>0.05). Both mesiobuccal and mesiolingual canals were shaped and filled with AH Plus and either LC technique or TPE gutta percha obturation technique. The specimens were stored for 1 week at 37 0C and 100% humidity to allow the complete setting of the sealer. Postoperative digital radiographs were taken to evaluate the quality of root canal fillings. Data were analysed using Mann-Whitney U tests. Result: In terms of the preparation techniques, no significant differences were found between the root canal filling techniques (p=0.051, p=0.127). Conclusion: Under the conditions of the present study, neither preparation nor obturation techniques did not affect the quality of root canal filling in curved root canals.
Investigation of human papillomavirus and epstein barr virus DNAs in pterygium tissue
(European Journal of Ophthalmology, 2009) Otlu, Barış; Emre, Sinan; Türkçüoğlu, Peykan; Doğanay, Selim; Durmaz, Rıza
Recent studies postulated the presence of a probable relationship between pterygium and neoplasia. This study aimed to investigate the role of two oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), in the development of conjunctival pterygia. METHODS. Polymerase chain reaction was used to identify the presence of HPV and EBV in 30 primary and 10 recurrent pterygia samples. Twenty conjunctival samples obtained from patients undergoing cataract surgeries were used as the control group. Patient groups had similar sex, race, and age distribution to eliminate bias. For exploration of HPV in groups, two different PCR methods (in-house PCR with two different primer sets and one real-time PCR method) were studied. The presence of EBV was shown by real-time PCR method. RESULTS. HPV was identified in none of the pterygia and control group patients. However, EBV was detected in 3 out of 30 (10%) primary pterygia patients and in none of the recurrent pterygia and control patients. CONCLUSIONS. Up to now, HPV has been blamed as the major viral pathogen in the etiopathogenesis of pterygium. The current results suggest that EBV may also be involved in the pathogenesis of pterygium, but further larger studies with larger cohorts are required to confirm this hypothesis.
Investigation of human papillomavirus and Epstein-Barr virus DNAs in pterygium tissue
(Sage Publications Ltd, 2009) Otlu, Baris; Emre, Sinan; Turkcuoglu, Peykan; Doganay, Selim; Durmaz, Riza
PURPOSE. Recent studies postulated the presence of a probable relationship between pterygium and neoplasia. This study aimed to investigate the role of two oncogenic viruses, human papillomavirus (HPV) and Epstein-Barr virus (EBV), in the development of conjunctival pterygia. METHODS. Polymerase chain reaction was used to identify the presence of HPV and EBV in 30 primary and 10 recurrent pterygia samples. Twenty conjunctival samples obtained from patients undergoing cataract surgeries were used as the control group. Patient groups had similar sex, race, and age distribution to eliminate bias. For exploration of HPV in groups, two different PCR methods (in-house PCR with two different primer sets and one real-time PCR method) were studied. The presence of EBV was shown by real-time PCR method. RESULTS. HPV was identified in none of the pterygia and control group patients. However, EBV was detected in 3 out of 30 (10%) primary pterygia patients and in none of the recurrent pterygia and control patients. CONCLUSIONS. Up to now, HPV has been blamed as the major viral pathogen in the etiopathogenesis of pterygium. The current results suggest that EBV may also be involved in the pathogenesis of pterygium, but further larger studies with larger cohorts are required to confirm this hypothesis. (Eur J Ophthalmol 2009; 19: 175-9)
Lens capsular glutathione level and glutathione peroxidase activity among diabetic patients
(2008) Emre, Sinan; Ateş, Burhan; Taşar, Ahmet; Doğanay, Selim
Abstract: Amaç: Bu çalışmada yaşa bağlı kataraktı bulunan hastalar ile sıkı kontrol altındaki diabet hastalarının lens ön kapsüllerinde ölçülen glutatyon (GSH) seviyesi ve glutatyon peroksidaz (GSH-Px) aktiviteleri değerlendirilmiştir. Yöntem: Çalışmaya tip II diabeti ve kataraktı bulunan hastalar ile yaş uyumlu olacak şekilde yaşa bağlı kataraktı bulunan hastalar dahil edildiler. Çalışma kapsamında sıkı diabet kontrolünde olan 18 hasta ile (Grup A), yaşa bağlı kataraktı bulunan 26 hastanın (Grup B) fakoemulsifikasyon yöntemi ile yapılan katarakt operasyonlarında alınan lens ön kapsülleri dahil edilmiştir. Örnekler çözünüp, santrifüje edilmelerinden sonra numunelerden GSH seviyeleri ve GSH-Px enzim aktiviteleri ölçülmüştür. Sonuçlar: Grup A ortalama yaşları 60.3 ± 8.3 yıl olan, 10 bayan ve 8 erkek hastadan oluşmaktaydı. Grup B ise ortalama yaşları 63.9 ± 12.2 yıl olan, 11 bayan ve 15 erkek hastadan oluşmaktaydı. Grup A ve B için lens ön kapsülünde ölçülen ortalama GSH seviyeleri sırasıyla 82.4±16.5 ve 97.5±12.5 nmol/mg iken ortalama GSH-Px aktivite düzeyleri sırasıyla 27.0±9.7 ve 36.9±9.3 ?mol/mg protein idi. Her iki parametre içinde gruplar arasındaki fark istatistiksel olarak anlamlı düzeyde tespit edilmedi (p>0.05). Yorum: Diabetin anti-oksidan mekanizmalar üzerindeki zararlı etkisi iyi bilinmektedir. Bizim sonuçlarımızda GSH seviyesinin ve GSH-Px aktivitelerinin sıkı kontrollü diabet grubunda ve yaşa bağlı kataraktı grubu arasında yakın değerlerde çıkmış olması, diabetin sıkı kontrolünün diabetin lens üzerindeki etkilerini hafifletmek bakımından önemli olduğunu düşündürtmektedir.
A new technique: argon green laser-Nd:YAG laser combination for the treatment of premacular haemorrhage
(Wiley-Blackwell, 2010) Emre, Sinan; Doganay, Selim; Demirel, Soner; Tasar, Ahmet
[Abstract Not Available]
Propolis Prevents the Effects of Chronic Alcohol Intake on Ocular Tissues
(Karger, 2009) Emre, Sinan; Yilmaz, Zuemruet; Ozturk, Feral; Emre, M. Hanifi
Aim: This study is designed to investigate the protective effects of propolis in ocular tissues against chronic alcohol exposure. Material and Method: Wistar albino rats were used in this study. Rats were divided into 4 groups, and each group was fed a special liquid diet which contained an equal amount of calories. The control group was fed the liquid special diet without alcohol and propolis. We added propolis (150 mg/kg) to the diet of the second group. The diet of the third group contained alcohol, the concentration of which was increased progressively. The fourth group was fed a diet including propolis and alcohol. To counterbalance caloric intake, we decreased the amount of glucose in the special liquid diet for groups 3 and 4. At the end of 30 days, the animals were sacrificed and samples were kept at -80 degrees C until evaluation. Specimens were investigated by light microscopy for morphology and morphometry. Results: In the histological investigation of ocular tissues, alcohol caused an increase in thickness of the cornea and corneal epithelium compared to the control group (p < 0.05). This incremental tendency was significantly reduced by propolis, and values were very close to those of the control group (p > 0.05). Alcohol did not cause any significant alteration of rat retinal thickness. Conclusion: This study showed that propolis is highly effective against corneal edema secondary to chronic alcohol intake. Copyright (C) 2009 S. Karger AG, Basel
Protective Effects of Melatonin and Aminoguanidine on the Cornea in Streptozotocin-induced Diabetic Rats
(Lippincott Williams & Wilkins, 2008) Gul, Mehmet; Emre, Sinan; Esrefoglu, Mukaddes; Vardi, Nigar
Purpose: This study was designed to investigate the protective effect of aminoguanidine (AG) and melatonin (M) on the cornea in a streptozotocin-induced diabetic rat model. Methods: Twenty-eight Sprague-Dawley rats were used in this study. Animals were divided into 4 groups: control (C), diabetes (D), diabetes + AG (D+AG), and diabetes + M (D+M). Diabetes was induced by 1 intraperitoneal dose of 45 mg/kg of streptozotocin (STZ). In the treatment groups, the D + AG group received AG in their water (1 g/L), and D + M rats were injected with M (10 mg/kg/d) intraperitoneally. One of the groups remained an untreated diabetic group (D group). All animals were euthanized at the end of 8 weeks. After enucleation, eyes were fixed in 10% phosphate-buffered formalin and embedded in paraffin wax. Histochemical stains were applied, and specimens were examined under a light microscope. Results: After 8 weeks, the rats in the diabetes group had significantly lower body weight and significantly higher blood glucose levels than those of the control, D + AG, and D + M groups. Diabetes resulted in prominent edema in the stroma with interruptions in the subepithelial basement membrane. These alterations were not prominent or were absent in the D + AG and D + M groups. The mean thicknesses of the cornea, corneal epithelium, and stroma were statistically significantly different between the C and D, and D and D + AG and D + M groups (P < 0.05). Conclusions: Long-term administration of AG and M reduced corneal injury in an STZ-induced diabetic rat model. AG and M may be potential candidates in the treatment of diabetic keratopathies. However, further studies are needed to elucidate the mechanisms of the protective effect of both molecules on diabetic corneal complications.
Transfusion transmitted virus DNA in serum tear and aqueous humour of patients undergoing cataract operation
(Clinical & Experimental Ophthalmology, 2007) Emre, Sinan; Otlu, Barış; Çankaya, Cem; Doğanay, Selim; Durmaz, Rıza
Purpose: Transfusion-transmitted virus (TTV) is a novel non-enveloped, single-stranded DNA virus with unclear pathogenesis throughout the world. Many studies were conducted to determine this virus in various body fluids and different primer sets have been tested for accurate diagnosis.This study aimed to collect data on the prevalence of TTV in serum, tear and aqueous humour of patients undergoing planned cataract surgery and to determine effi- cacy of three different polymerase chain reaction (PCR) techniques. Methods: A total of 72 specimens (24 each of serum, tear and aqueous humour specimens) were collected from 24 patients (11 male and 13 female) having age-related cataract. The patients did not have any other ocular pathology. TTV DNA was investigated by three different PCR methods: a seminested PCR performed with Okamato’s primers, a one-step PCR performed with degenerative Takashi’s primers and a commercial real-time PCR system. Results: TTV DNA was detected in 20 (83.3%) of the 24 serum specimens by the one-step PCR and real-time PCR system. However, seminested PCR yielded a positivity rate of 25%.TTV DNA positivities of the one-step PCR and the real-time PCR system were 33.3% and 66.6% of the 24 tear specimens, respectively. Seminested PCR did not yield positive result in these specimens. From aqueous humour specimens, TTV DNA was detected in 3 (12.5%) of the 24 specimens only by the real-time PCR.TTV DNA positivity of seminested PCR was significantly low in all specimens. Conclusions: TTV DNA was detected in serum, tear and aqueous humour of patients undergoing cataract surgery, suppor ting the idea that this virus can be detected almost all of the body fluids but at different rates under various PCR conditions and primer sets. Using commercial real-time PCR significantly increased the TTV DNA positivity.
What is the ımportance of Demodex folliculorum in Behçet's disease?
(2009) Emre, Sinan; Aycan, Makbule Ö.; Atambay, Metin; Bilak, Şemsettin; Daldal, Nilgün; Karıncaoğlu, Yelda
Abstract: Demodex folliculorum, insan pilosebase bezlerinin zorunlu bir parazitidir ve sıklıkla immun sistem yetmezliği bulunan kişilerde tespit edilmektedir. Bu çalışmanın amacı, Demodex folliculorum sıklığını Behçet hastalığı bulunan hastalarda araştırmaktır. Çalışmaya İnönü Üniversitesi Tıp Fakültesi Göz hastalıkları Anabilim dalında takipleri yapılan ve Dermatoloji Anabilim dalınca refere edilen 40 Behçet hastası dahil edilmişlerdir. Refraksiyon problemleri dışında sistemik ve oküler herhangi bir hastalığı olmayan 131 hasta ile kontrol grubu oluşturulmuştur. Parazit tespiti için, her bir alt kapaktan üçer adet kirpik epile edilmiştir. Ayrıca hastaların yanak yüzlerinde parazit tespiti için standart cilt yüzey biyopsisi (SCYB) uygulanmıştır. Epile edilen kirpikler ve cilt testleri Hoyer solusyonu uygulanarak, x100 büyütmeli ışık mikroskobunda incelenmişlerdir. Çalışma grubu 15 bayan, 25 erkek Behçet hastasından, kontrol grubu 61 bayan, 70 erkek hastadan oluşmaktaydı. Grupların ortalama yaşları sırasıyla 37.62 ve 38.38 idi. Behçet hastalarında kirpik diplerinde Demodex folliculorum sıklığı % 65, kontrol grubunda % 10'du. Cilt SCYB sonuçlarına göre Demodex folliculorum sıklığı Behçet hastalarında % 7.5, kontrol grubunda % 10'du. İstatistiksel analiz, kirpik dipleri için farkın anlamlı olduğunu (p<0.05) ancak yanak yüzeyleri için anlamlı olmadığını ortaya koymuştur. Behçet hastalarında Demodex folliculorum sıklığının araştırılması, şikayetleri olmasa bile bu hastalarda oküler yüzey ve gözkapağı problemlerinin tedavisinde faydalı olabilir.

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