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Öğe Hematological Abnormalities in Patients With Acute Viral Hepatitis A and B(Aves Yayincilik, Ibrahim Kara, 2008) Akarsu, Saadet; Erensoy, Ahmet; Elkiran, Ozlem; Kurt, Abdullah; Kurt, A. Nese Citak; Aygun, A. DenizmenAim: Acute viral hepatitis A (HA) and B (HB) are currently widespread health problems in developing countries, where poor hygienic conditions are prevalent. Extrahepatic abnormalities which involve many organs and systems can accompany these infections. Therefore we wanted to determine the rate of hematological complications in our cases diagnosed as HA and HB. Material and Methods: Referral test results of a total of 322 cases hospitalized and monitored with diagnoses of HA (Group 1: 219 cases) and HB (Group 2: 103 cases) were analysed retrospectively. Diagnosis of HA was established by Anti-HAV IgM antibody positivity and diagnosis of HB by elevated liver function tests, HbsAg and HBeAg positivity. Results: Mean leukocyte (8.405 +/- 2.682/mm(3)), neutrophil (3.985 +/- 1.880/mm(3)), hemoglobin levels (12.7 +/- 1.4 g/dl) and platelet counts (339.149 +/- 123.578/mm(3)) were determined. The total rate of hematologcal abnormalities was 59.32 % ( HA 58 %, HB 61.6 %), while the rates of leukopenia (0.93 %), leukocytosis (20.81 %), neutropenia (6.21 %), anemia (15.52 %), thrombocytopenis (4.35 %) and thrombocytosis (11.49 %) were also assessed. No cases of pancytopenia was detected. Conclusion: Hematological abnormalities were seen in nearly half of the cases with HA and HB, which constitute important public health problems in our country. The rates of hematological abnormalities were similar in HA and HB.Öğe Molecular discrimination of Echinococcus granulosus and Echinococcus multilocularis by sequencing and a new PCR- RFLP method with the potential use for other Echinococcus species(2014) Sakalar, Çağrı; Kuk, Salih; Erensoy, Ahmet; Dağlı, Adile Ferda; Özercan, İbrahim Hanifi; Çetinkaya, Ülfet; Yazar, SüleymanBackground/aim: To develop a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol using a new genomic marker sequence and a novel set of restriction enzymes in order to detect and discriminate 2 Echinococcus species, E. granulosus and E. multilocularis, found in formalin-fixed paraffin-embedded (FFPE) human tissues. Materials and methods: DNA was isolated from 11 FFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis. A mitochondrial genomic marker region was amplified and sequenced using a novel primer pair and a new PCR-RFLP protocol was developed for the detection and discrimination of E. granulosus and E. multilocularis using a set of restriction enzymes including AccI, MboI, MboII, and TsoI. Results:The selected marker region was amplified using DNA isolated fromFFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis and the discrimination of E. granulosus and E. multilocularis was accomplished by use of the novel PCR-RFLP method. Conclusion: In this PCR-RFLP protocol, use of any single restriction enzyme is enough for the discrimination of E. granulosus and E. multilocularis. The PCR-RFLP protocol can be potentially used for the discrimination of 5 other Echinococcus species: E. oligarthus, E. shiquicus, E. ortleppi, E. canadensis, and E. vogeli.Öğe Molecular discrimination of Echinococcus granulosus and Echinococcus multilocularis by sequencing and a new PCR-RFLP method with the potential use for other Echinococcus species(Tubitak Scientific & Technological Research Council Turkey, 2014) Sakalar, Cagri; Kuk, Salih; Erensoy, Ahmet; Dagli, Adile Ferda; Ozercan, Ibrahim Hanifi; Cetinkaya, Ulfet; Yazar, SuleymanBackground/aim: To develop a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol using a new genomic marker sequence and a novel set of restriction enzymes in order to detect and discriminate 2 Echinococcus species, E. granulosus and E. multilocularis, found in formalin-fixed paraffin-embedded (FFPE) human tissues. Materials and methods: DNA was isolated from 11 FFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis. A mitochondrial genomic marker region was amplified and sequenced using a novel primer pair and a new PCR-RFLP protocol was developed for the detection and discrimination of E. granulosus and E. multilocularis using a set of restriction enzymes including AccI, MboI, MboII, and TsoI. Results: The selected marker region was amplified using DNA isolated from FFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis and the discrimination of E. granulosus and E. multilocularis was accomplished by use of the novel PCR-RFLP method. Conclusion: In this PCR-RFLP protocol, use of any single restriction enzyme is enough for the discrimination of E. granulosus and E. multilocularis. The PCR-RFLP protocol can be potentially used for the discrimination of 5 other Echinococcus species: E. oligarthus, E. shiquicus, E. ortleppi, E. canadensis, and E. vogeli.Öğe The Republican People's Party and İsmet İnönü at the Transition Into the Multiparty System at the End of Second World War(2008) Akarsu, Saadet; Erensoy, Ahmet; Elkıran, Özlem; Kurt, Abdullah; Kurt Çıtak, Neşe; Aygün, DenizmenAbstract:Amaç: Akut viral hepatit A (HA) ve B (HB) kötü hijyen koşullarının olduğu gelişmekte olan ülkelerde halen yaygın bir sağlık sorunudur. Çeşitli organ ve sistemleri tutan ekstrahepatik anormallikler de bu infeksiyona eşlik edebilir. İnfeksiyonun seyri sırasında kemik iliği hipoplazisi ve bazen de aplazi görülebilir. Bizde HA ve HB tanısı alan olgularda hematolojik anormalliklerin görülme oranlarını belirlemek istedik. Materyal ve Yöntem: HA (Grup 1: 219 olgu) ve HB (Grup 2: 103 olgu) tanısı ile yatırılarak izlenen toplam 322 olgunun başvuru değerleri retrospektif olarak incelendi. HA tanısı anti-HAV IgM yanıtı pozitifliği ve HB tanısı ise artmış karaciğer fonksiyon testleri, HbsAg (+) ve HBeAg (+)’liği ile konuldu. Bulgular: Ortalama lökosit sayısı (8.405±2.682/mm3), nötrofil sayısı (3.985±1.880/mm3), hemoglobin değeri (12.7±1.4g/dl) ve trombosit sayısı (339.149±123.578/mm3) olarak saptandı. Toplam hematolojik anormalliklerin oranı %59.32 (HA %58, HB %61.6) iken lökopeni (%0.93), lökositoz (%20.81), nötropeni (%6.21), anemi (%15.52), trombositopeni (%4.35) ve trombositoz (%11.49) olarak saptandı. Pansitopeni gelişen olgu saptanmadı. Sonuç: Ülkemizde halen önemli bir halk sağlığı sorunu olan HA ve HB olgularının yaklaşık yarısında hematolojik komplikasyon görülmektedir. HA ve HB’de görülen hematolojik anormallik oranları benzerdir.
