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    Oxidative stress and altered levels of antioxidants in adolescents with Down syndrome during pre-exercise and post-exercise
    (Academic Journals, 2012) Ozbey, Ulku; Arslan, Cengiz; Savucu, Yuksel; Erisir, Mine; Seyran, Ayse
    The aim of this study was to determine the influence of exercise on activity of erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and plasma malondialdehyde (MDA), beta-carotene, retinol levels in adolescents with Down syndrome (DS). Twenty adolescents with DS (14.86 +/- 7.07 years) performed a 12-week training program. Body composition was measured by bioelectric impedance method. SOD, GPx, CAT, MDA, retinol, beta-carotene levels was determined spectrophotometrically. When compared to baseline, MDA level was increased (P<0.05). SOD, GPx activities and beta-carotene level were decreased (P<0.05). There was no difference during pre-post exercise in terms of CAT activity and retinol level (P>0.05). The mean value of percentage of fat mass was reduced. Regular exercise decreased SOD, GPx activities and beta-carotene level and did not affect CAT activity and retinol level in individuals with DS. Exercise increases oxidative stress depending on level of training.
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    Rock salt and boron supplementation: Effects on oxidative stress in blood and semen of rams
    (Hellenic Veterinary Medical Soc, 2025) Akarsu, Selcukhan; Simsek, Ulku Gulcihan; Erisir, Mine; Sonmez, Mustafa; Gungor, Ibrahim Halil; Acisu, Tutku Can; Erdem, Mehmet
    This study aimed to investigate the effects of boron and rock salt minerals, which are interesting as antioxidant minerals on malondialdehyde (MDA) and some antioxidants; glutathione level (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) enzyme activities in blood and sperm cells. For this purpose, a total of 36 rams were divided into six research groups, with six rams in each group. The research groups were designed as Control (Just 40 ml water), Salt (10 g rock salt/day), B20 (20 mg boric acid/day), B40 (40 mg boric acid/day), BT20 (20 mg boric acid + 10 g rock salt/day), BT40 (40 mg boric acid + 10 g rock salt/day). The additives were dissolved in 40 ml of water and administered orally with 50 ml syringes for 80 days. Semen and blood samples were taken from the rams at the end of the experiment. Salt added to the diet significantly increased MDA levels in blood and sperm cells. A significant decrease in plasma MDA levels were observed in the BT40 group and sperm cells in the B40 and BT40 groups. Salt and boric acid were found to be effective on GSH and antioxidant enzymes. In conclusion, it was found that boric acid added to the diet at a dose of 40 mg enhanced antioxidant metabolism and significantly reduced salt-induced lipid peroxidation.