Yazar "Ertas, Busra" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic ?-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats
    (Elsevier Ireland Ltd, 2019) Cam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Yildiz, Sila; Ertas, Busra; Adakul, Betul Ayaz; Taskin, Turgut; Alan, Saadet
    Ethnopharmacological relevance: Thymus praecox subsp. skorpilii var. skorpilii (syn. Thymus praecox subsp. jankae (Celak.) Jalas) is consumed as a Turkish folk medicine for the treatment of spasm, sore throat and shortness of breath, also having strong antioxidant activity and the leaves of the plant have been utilized for the treatment of diabetes as the decoction in Turkey. Aim of the study: In the present study, we aimed to investigate the potential mechanism of antidiabetic action of Thymus praecox subsp. skorpilii var. skorpilii methanolic extract (TPSE) on streptozotocin (STZ)/nicotinamide (NA)-induced type 2 diabetic rats. Materials and methods: Sprague Dawley rats were randomly divided into four groups; control, diabetes, TPSE (100 mg/kg b.w, p.o.) and metformin group (400 mg/kg b.w, p.o.). Diabetes was established in all groups except control group by 55 mg/kg STZ (i.p.) for once 15 min after 100 mg/kg NA injection. 3 days after STZ/NA injection, treatments were administered for three weeks and then rats were decapitated; tissue and blood samples were obtained for measuring the level of glucose transporters (both GLUTs and sodium glucose co-transporters (SGLTs)), enzymes related to glucose (Hexokinase (HK), phosphoenolpyruvate carboxykinase (PEPCK), alpha-glucosidase) and lipid metabolism (Acetyl-coenzyme carboxylase (ACC)), AST, ALT, creatinine, insulin, anti-inflammatory (IL-10) and inflammatory (TNF-alpha, IL-1 beta, IL-6) cytokines, AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPAR-gamma) and glucagon like peptide-1 (GLP-1). Histopathological alterations of the pancreas were examined. Results: After three weeks of treatment, TPSE has exhibited a significant reduction of plasma levels of the proinflammatory cytokines. Besides, TPSE treatment elevated plasma insulin levels and normalized blood glucose levels. Moreover, it improved the values of AMPK in liver and GLP-1 in pancreas. Increased a-glucosidase, PEPCK, GLUT-2 and SGLTs levels with the induction of diabetes considerably lowered with TPSE treatment. Especially on SGLT-2, TPSE achieved a more prominent decrease. After the atrophy in Langerhans islets due to
  • Küçük Resim Yok
    Öğe
    Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004
    (Marmara Univ, Fac Medicine, 2025) Ozkurt, Selnur; Dogan, Bedriye; Ozyilmaz, Nagehan; Aykac, Asli; Ertas, Busra; Sen, Ali; Ceylan, Cemile
    Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days. Ionizing radiation (IR) groups were organized as follows: IR group (IR) (n=8) received oral SF for four days starting on the day of administration; MC treatment group (MC-tx) (n=8) received oral MC for four days beginning on the day of irradiation; and MC pretreatment group (MC-Ptx) (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC was administered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats were sacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting to assess mitochondrial apoptosis. Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower in the MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01). Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic and therapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.