Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara Univ, Fac Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days. Ionizing radiation (IR) groups were organized as follows: IR group (IR) (n=8) received oral SF for four days starting on the day of administration; MC treatment group (MC-tx) (n=8) received oral MC for four days beginning on the day of irradiation; and MC pretreatment group (MC-Ptx) (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC was administered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats were sacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting to assess mitochondrial apoptosis. Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower in the MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01). Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic and therapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection.
Açıklama
Anahtar Kelimeler
Bladder, Kidney, Myrtus communis, Radioprotection, Rats, Ovary
Kaynak
Marmara Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
38
Sayı
3
