Yazar "Eskin, Ahmet" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    İntramedüller elektrik stimulasyonu ile angiogenezin artırılması
    (İnönü Üniversitesi, 2003) Eskin, Ahmet
    Yedinci günde yapılan değerlendirme parametrelerinin sonuçlarına paralel olarak interfasiküler alandaki oluşan kapiller sayısı yönünden tel ve elektrik ile delik ve elektrik grubu arasında (p=0.021), fibrotik değişimler yönünden de elektrik ve kontrol grubu arasında anlamlı istatistiki fark (p=0.013) izlenmiş olması bize elektriksel uyan ile yapılan anjiogenez modelinin literatürde bilinenin aksine anjiogenez oluşumuna katkıda bulunduğu, anjiogeneze katkısı olsa da özellikle yirmibirinci günde oldukça belirgin olarak gelişen fibrozisin anjiogenezi bloke ettiğini düşündürmektedir. Tüm bu bulgular ışığında yapılabilecek yorum ise tel uygulamasının anjiogenezi uyarmada ortalama elektrik uyansı kadar başanlı olduğu ve aynca fibrozis yapmadığıdır. Endikasyon grubu dahilindeki hastalarda ciddi potansiyel komplikasyonlar oluşturmaksızm relatif olarak ucuz bir yöntem olan tel ile intrameduller anjiogenez uyansı uygulaması ile başanlı sonuçlar elde edilebilir. Ancak her iki yöntemin kesin başansmı kanıtlamak için kontrol gruplu, çift kör ve çok merkezli çalışmalara ihtiyaç vardır.
  • Küçük Resim
    Öğe
    The mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healing
    (Tex Heart Inst J, 2004) Alat, İlker; İnan, Muharrem; Gürses, İclal; Kekilli, Ersoy; Germen, Burak; Harma, Ahmet; Eskin, Ahmet; Ayın, Ömer Murat
    We induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.
  • Küçük Resim
    Öğe
    The mechanical or electrical induction of medullary angiogenesis will it improve sternal wound healing
    (Tex Heart Inst J, 2004) Alat, İlker; İnan, Muharrem; Gürses, İclal; Kekilli, Ersoy; Germen, Burak; Harma, Ahmet; Eskin, Ahmet; Aydın, Ömer Murat
    We induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2, a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery. (Tex Heart Inst J 2004;31:363-7)