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Synthesis of benzotriazole-amino acid-benzenesulfonamide conjugates and phenylsulfonyl-dipeptides
(Arkat Usa Inc, 2024) Ezugwu, James Anayochukwu; Kucukbay, Hasan
L-Amino acids were converted into sulfonamides by reaction with phenylsulfonyl chloride in a basic medium. Subsequent treatment of these sulfonamides with 1H-benzotriazole (BtH) and thionyl chloride at room temp erature yielded benzotriazole-amino acid-benzenesulfonamide conjugates with yields ranging from 42% to 68%. Furthermore, the reaction of the benzotriazole derivatives with free glycine and free phenylalanine resulted in the formation of (phenylsulfonyl)dipeptides.