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    Association of folic acid receptor ? in maternal serum with neural tube defects
    (Informa Healthcare, 2014) Celik, Ebru; Karaer, Abdullah; Turkcuoglu, Ilgin; Turhan, Ugur; Gungoren, Arif; Taskapan, Cagatay; Ozyalin, Fatma
    Objective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs). Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07). Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.
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    YKL-40 and fibronectin levels in patients with placental invasion anomaly
    (2021) Soylu Karapinar, Oya; Sahin, Hanifi; Gozukara, Ilay; Adeviye Sahin, Eda; Ozcan, Oguzhan; Sezgin, Burak; Gungoren, Arif
    Aim: To investigate the level of YKL-40 and fibronectin in patients with total placenta previa and to evaluate the presence of placental invasion anomaly such as accreta. Materials and Methods: A total of 60 patients were included in this prospective study. The patients were classified according to the placental localization as assessed through ultrasound. The study group consisted of 33 patients diagnosed with placenta previa or accreta with previous cesarean section. These patients were also subdivided into two groups according to the histopathological examination results as invasion-positive group and invasion-negative group. The control group consisted of 27 patients who were admitted to the gynecology clinic with previous cesarean deliveries and had normal placental localization. Serum YKL-40 and fibronectin levels were measured in two groups via human chitinase-3-like protein 1 (Ykl-40/CHI3L1) and fibronectin enzyme-linked immunosorbent assay kits. Results: Mean serum levels for YKL-40 and fibronectin were similar between the study and control groups. In the subgroup analysis according to invasion anomaly, the level of YKL-40 in invasion-positive group (n=11) was higher than invasion-negative group (n=22), indicating a statistically significant difference. Conclusion: Outcomes of this research indicates that YKL-40 can be used as a marker for identifying placental invasion anomalies.