Association of folic acid receptor ? in maternal serum with neural tube defects
Küçük Resim Yok
Tarih
2014
Yazarlar
Celik, Ebru
Karaer, Abdullah
Turkcuoglu, Ilgin
Turhan, Ugur
Gungoren, Arif
Taskapan, Cagatay
Ozyalin, Fatma
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs). Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07). Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.
Açıklama
Anahtar Kelimeler
Folate, folic acid receptor alpha, maternal serum, neural tube defect
Kaynak
Journal of Maternal-Fetal & Neonatal Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
27
Sayı
11
