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    Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model
    (Elsevier Gmbh, Urban & Fischer Verlag, 2014) Gurses, Iclal; Ozeren, Murat; Serin, Meltem; Yucel, Neslihan; Erkal, Haldun Sukru
    Introduction: Melatonin is a hormone which is known to be a powerful cardioprotective agent due to its free radical-scavenging properties. This study was carried out to evaluate whether melatonin administration prior to irradiation would have a protective effect on cardiac histopathological changes in an experimental rat model. Methods: Rats were divided into four groups. Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. 50 mg/kg dose of melatonin were injected intraperitonally 15 min prior to radiation exposure. Analyses and assessments were performed 6 months after radiation exposure. Results: Severe myocardial fibrosis was observed prominently in three regions: the apex, tips of papillary muscles and adjacent to the atrioventricular valves. Inflammation was found to be more in irradiated groups. Increased inflammation and fibrosis were in concordance. The number of mast cells was found to be decreased in irradiated groups. Myocyte necrosis and fibrosis were diminished with melatonin while vasculitis was prevented. Conclusions: Elementary pathological lesions of radiation-induced heart disease (RIHD) are fibrosis, vascular damage, vasculitis and myocyte necrosis. Development of vasculitis was prevented by the use of melatonin. Fibrosis and necrosis were prominently decreased. Prevention of RIHD with the use of melatonin at the long term is encouraging according to the histopathological results. (C) 2014 Elsevier GmbH. All rights reserved.
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    Investigation of microorganisms in cases of mammary duct ectasia by histochemical methods
    (Springer, 2007) Gurses, Iclal; Karabacak, Tuba; Mizrak, Bulent
    [Abstract Not Available]
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    Toxic-Inflammatory Effects of Prostoglandin Analogs on the Ocular Surface
    (Taylor & Francis Inc, 2013) Demirel, Soner; Doganay, Selim; Gurses, Iclal; Iraz, Mustafa
    Purpose: To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Materials and methods: Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no treatment. Dysplasia and keratinization were evaluated on the ocular surface. In the subepithelial area, the number of lymphocytes and mast cells were counted morphologically, and collagen staining densities were compared subjectively in groups. Results: The ratio of keratinization was 3/12 and 1/10, in groups I and II. The lymphocyte cell counts were 1.4 +/- 0.19, 2.2 +/- 0.39, 2.27 +/- 0.33, and 1.87 +/- 0.35 (p>.05). The mast cell counts were 2.58 +/- 0.5, 5.4 +/- 1.1, 5.7 +/- 0.58, and 3.0 +/- 0.59. They were significantly higher in groups II and III than in group I (p<.05). Mean collagen density scores were 1.00 +/- 0.85, 2.00 +/- 0.00, and 1,73 +/- 0.70. Group II and III scores were higher than group I scores (p<.05). Conclusion: Latanoprost and travoprost seem to have more toxic-inflammatory effects on the ocular surface than bimatoprost.