Toxic-Inflammatory Effects of Prostoglandin Analogs on the Ocular Surface
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Materials and methods: Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no treatment. Dysplasia and keratinization were evaluated on the ocular surface. In the subepithelial area, the number of lymphocytes and mast cells were counted morphologically, and collagen staining densities were compared subjectively in groups. Results: The ratio of keratinization was 3/12 and 1/10, in groups I and II. The lymphocyte cell counts were 1.4 +/- 0.19, 2.2 +/- 0.39, 2.27 +/- 0.33, and 1.87 +/- 0.35 (p>.05). The mast cell counts were 2.58 +/- 0.5, 5.4 +/- 1.1, 5.7 +/- 0.58, and 3.0 +/- 0.59. They were significantly higher in groups II and III than in group I (p<.05). Mean collagen density scores were 1.00 +/- 0.85, 2.00 +/- 0.00, and 1,73 +/- 0.70. Group II and III scores were higher than group I scores (p<.05). Conclusion: Latanoprost and travoprost seem to have more toxic-inflammatory effects on the ocular surface than bimatoprost.
Açıklama
Anahtar Kelimeler
Bimatoprost, Glaucoma, Latanoprost, Preservative, Travoprost
Kaynak
Ocular Immunology and Inflammation
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
21
Sayı
1
