Toxic-Inflammatory Effects of Prostoglandin Analogs on the Ocular Surface

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dc.authoridKantarci, Mecit/0000-0002-1043-6719
dc.authorwosidGürses, İclal/AAH-8552-2021
dc.authorwosidKantarci, Mecit/HLQ-6851-2023
dc.contributor.authorDemirel, Soner
dc.contributor.authorDoganay, Selim
dc.contributor.authorGurses, Iclal
dc.contributor.authorIraz, Mustafa
dc.date.accessioned2024-08-04T20:37:23Z
dc.date.available2024-08-04T20:37:23Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Materials and methods: Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no treatment. Dysplasia and keratinization were evaluated on the ocular surface. In the subepithelial area, the number of lymphocytes and mast cells were counted morphologically, and collagen staining densities were compared subjectively in groups. Results: The ratio of keratinization was 3/12 and 1/10, in groups I and II. The lymphocyte cell counts were 1.4 +/- 0.19, 2.2 +/- 0.39, 2.27 +/- 0.33, and 1.87 +/- 0.35 (p>.05). The mast cell counts were 2.58 +/- 0.5, 5.4 +/- 1.1, 5.7 +/- 0.58, and 3.0 +/- 0.59. They were significantly higher in groups II and III than in group I (p<.05). Mean collagen density scores were 1.00 +/- 0.85, 2.00 +/- 0.00, and 1,73 +/- 0.70. Group II and III scores were higher than group I scores (p<.05). Conclusion: Latanoprost and travoprost seem to have more toxic-inflammatory effects on the ocular surface than bimatoprost.en_US
dc.identifier.doi10.3109/09273948.2012.723106
dc.identifier.endpage11en_US
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue1en_US
dc.identifier.pmid23323576en_US
dc.identifier.scopus2-s2.0-84872291837en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.3109/09273948.2012.723106
dc.identifier.urihttps://hdl.handle.net/11616/95922
dc.identifier.volume21en_US
dc.identifier.wosWOS:000313682500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofOcular Immunology and Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBimatoprosten_US
dc.subjectGlaucomaen_US
dc.subjectLatanoprosten_US
dc.subjectPreservativeen_US
dc.subjectTravoprosten_US
dc.titleToxic-Inflammatory Effects of Prostoglandin Analogs on the Ocular Surfaceen_US
dc.typeArticleen_US

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