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    The effects of Gingko biloba extract on acetic acid induced colitis in rats
    (Turk J Gastroenterol, 2006) Harputluoğlu, Muhsin Murat Muhip; Demirel, Ulvi; Yücel, Neslihan; Karadağ, Neşe; Temel, İsmail; Fırat, Serpil; Ara, Cengiz; Aladağ, Murat
    Background/aims: Gingko biloba is an antioxidant substance which has antagonistic activity on platelet-activating factor. We aimed to investigate the antioxidant effect and the histopathologic changes caused by Gingko biloba on acetic acid-induced colitis. Methods: Totally 22 rats were divided into three groups. Group 1 (n=7) served as the control group. Group 2 (n=7) and Group 3 (n=8) were given 2 ml/day of 4% acetic acid by intracolonic instillation for three days. Gingko biloba (100 mg/kg) was then given only to Group 3 intraperitoneally for three days. Oxidative stress was assessed by determinate tissue and serum malondialdehyde (MDA) levels, and colonic damage was assessed by histologic examination. Results: Depth of necrosis, extent of necrosis, degree of inflammation, extent of inflammation, fibrosis and total histologic scores in Group 2 were significantly higher than in the control group (p<0.05). The same parameters were lower in Group 3 versus Group 2, but the difference was not significant. Tissue and serum MDA levels in Group 2 were significantly higher than Group 1 (p<0.01 and 0.05, respectively). Again, the same parameters in Group 3 were lower than in Group 2, but the difference was not significant statistically. Conclusions: Gingko biloba did not significantly affect histopathological and oxidative stress parameters in experimental colitis.
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    The Relationship Between Hepatic Activity Index and Serum Tumor Necrosis Factor Alpha Levels in Patients with Chronic Active Hepatitis-B and Chronic Active Hepatitis-C
    (2015) Bilgiç, Yılmaz; Harputluoğlu, Muhsin Murat Muhip; Dal, Mehmet Burak; Bozan, Mehmet Buğra; Şahin, Abdurrahman; Yazar, Fatih Mehmet; Çağın, Yasir Furkan
    Abstract: In the present study, we investigated the relationship between serum TNF-? levels and hepatic activity in liver biopsies of chronic hepatitis B and C patients.The study was performed on 30 chronic hepatitis B patients, 25 chronic hepatitis C patients and 25 healthy controls. Serum samples of patients who underwent biopsy and healthy controls were collected. Control group was seronegative for hepatitis and had normal liver function tests. TNF- ? levels measured by ELISA. Knodell’s hepatic activity index was used in evaluation of liver biopsies. Serum TNF? levels were determined higher in chronic hepatitis B and C patients than control group. HAI and TNF- ? compared in chronic hepatitis B and C patients. Although we detected a relationship between HAI and TNF-? levels in chronic hepatitis B patients, no true correlation was shown in chronic hepatitis C patients. Cytokines have an important role in progression of chronic hepatitis B and C infections. There is a relationship between hepatic activity index and TNF-? level in chronic hepatitis B infection.But There is not relationship between hepatic activity index and chronic hepatitis C infection.only in two patients and both of them where in the middle of their reproductive age while as symptomatic ovarian cysts was a more common finding in unmarried females in 21-28 years of age group. This study concluded that laparoscopy has a diagnostic as well as a therapeutic implication in management of NSAP
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    Single center analysis of the first 304 living donor liver transplantations in 3 years
    (Hepatogastroenterology, 2013) Yılmaz, Sezai; Kayaalp, Cüneyt; Ara, Cengiz; Yılmaz, Sezai; Işık, Burak; Özgör, Dinçer; Dinçer, Özgür; Burçin, Ayşe; Ünal, Bülent; Pişkin, Turgut; Selimoğlu, Mukadder Ayşe; Harputluoğlu, Muhsin Murat Muhip; Karabiber, Hamza; Yalçın, Kendal; Kırımlıoğlu, Vedat
    BACKGROUND/AIMS: Living donor liver transplantations (LDLT) is a definitive treatment for patients with end-stage liver disease (ESLD), especially in the countries with donation problem. Between April 2007 and April 2010, we performed LDLT in 289 patients. Fifteen of the cases required re-transplantations. This study evaluates these 304 consecutive LDLTs donor and recipient outcomes. METHODOLOGY: Complication rates and survival data of the recipients and donors of 304 LDLT cases were analyzed. RESULTS: All donors are alive and well. Overall complication rate was 27%. Early postoperative recipient complication rate was 51%. Most frequent complication was infection. In the long-term there were 57 biliary stricture and 5 chronic bile fistula cases. Chronic and acute rejection attacks developed in 7 and 103 patients, respectively. Hepatic artery thrombosis rate was 8%. One, two and three year survival rates were 82%, 79% and 75%, respectively. Recipient mortality was 25%, mostly due to vascular complications, septic complications, liver dysfunction and chronic rejection. CONCLUSIONS: More than 150 liver tranplantations per year in a single center is a challenge in Turkey, where there is a shortage of deceased donor grafts. LDLT is a safe procedure for donors and effective for ESLD. Improvement in surgical technique would provide better outcomes.