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Öğe Acute effects of electronic cigarette smoking on ventricular repolarization in adults(Makerere Univ, Coll Health Sciences,Sch Med, 2020) Demir, Vahit; Hidayet, Siho; Turan, Yasar; Ede, HuseyinBackground: Electronic cigarette (e-cigarette) use is constantly increasing. However, the association between e-cigarette use and ventricular arrhythmia is unknown. Thus, in this study, we aimed to evaluate the markers of ventricular repolarization such as QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tp-e), corrected Tp-e and Tp-e/QT ratios in e-cigarette users. Methods: The study population consisted 36 e-cigarette users and 40 healthy subjects. Ventricular repolarization parameters were obtained from 12-lead resting electrocardiogram. Ventricular repolarization parameters of the groups were compared. Results: Basal demographic and laboratory data were similar in both groups. According to the electrocardiographic parameters, the Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were significantly higher in individuals using e -cigarettes than in control subjects [74.9 +/- 6.4 milliseconds (ms) vs. 80.1 +/- 4.1ms, <0.001; 82.9 +/- 7.5 ms vs. 87.8 +/- 6.3 ms, p=0.003; 0.20 +/- 0.01 vs. 0.21 +/- 0.01, p=0.002; respectively]. Conclusion: This is the first study to show the disruption of ventricular repolarization properties in e-cigarette users. E -cigarette use in terms of public health leads to augmentation of transmural dispersion of repolarization, which may be potential indicator of ventricular arrhythmogenesis.Öğe Adipsin as a novel prognostic biomarker for cardiovascular diseases(Czech Soc Cardiology & Czech Soc Cardiovascular Surgery, 2022) Askin, Lutfu; Askin, Husna Sengul; Abus, Sabri; Hidayet, SihoIncreased vascular oxidative stress stimulates the secretion of adipokines from adipocytes. Many clinical studies have demonstrated that plasma adipsin levels are successful in predicting ischemic events. Increased adipsin levels are closely related to all-cause death and morbidity. Therefore, adipsin may be a new biomarker for atherosclerosis. In this review, we aimed to emphasize the association of adipsin with cardiovascular diseases (CVDs) and its beneficial role in the therapeutic field of CVDs.Öğe Assesment of Left Atrial Volume in Patients with Mitral Annular Calcification With Real-Time Three-Dimensional Echocardiography(Elsevier Science Inc, 2013) Bayramoglu, Adil; Otlu, Yilmaz Omur; Hidayet, Siho; Tasolar, Hakan; Kurt, Fuat; Pekdemir, Hasan[Abstract Not Available]Öğe Assessment of left atrial volume and function by real time three-dimensional echocardiography in obese patients(Wiley, 2017) Yagmur, Julide; Cansel, Mehmet; Kurtoglu, Ertugrul; Hidayet, Siho; Acikgoz, Nusret; Ermis, Necip; Ozyalin, FatmaObjective: To evaluate left atrial (LA) volume and functions in obese subjects using real time three-dimensional echocardiography (RT3DE) and also the relationship between LA mechanical functions and N-terminal pro-atrial natriuretic peptide (NT-proANP). Methods: This study included 40 obese (26 females and 14 males, mean age 51.9 years) and 40 normal weight subjects (23 females and 16 males, mean age 53.5 years) with normal coronary angiograms. All the study participants underwent RT3DE to assess LA volume and mechanical function. Plasma NT-proANP was determined by ELISA method. Results: There was no significant difference between groups in left ventricular (LV) diameters and ejection fraction, which reflect LV systolic function. However, transmitral deceleration time, isovolumetric relaxation time, and peak late diastolic tissue Doppler velocity values, which reflect LV diastolic function, were found to be significantly higher in obese subjects when compared with controls. LA maximum volume (LAVmax), LAVmax index (LAVI), LA minimal volume (LAVmin), before atrial contraction volume (LAVpreA), LA active emptying volume, LA total emptying volume, and LA active emptying fraction, which reflect LA reservoir and pump functions, were also higher in obese subjects when compared with controls. LA passive emptying fraction was significantly lower in obese subjects than in controls. NT-proANP levels were similar between groups. There were positive correlations between NT-proANP level and LAVI, LAVmax, LAVmin, LAVpreA, and LA total and active emptying volumes. Conclusions: Left atrial mechanical functions and volumes are impaired in obese subjects. These findings may be regarded as early markers of subclinical cardiac failure in obese subjects who have not yet exhibited any clinical evidence of cardiovascular disease.Öğe Assessment of left atrial volume and function by real time three-dimensional echocardiography inobese patients(Wıley, 111 rıver st, hoboken 07030-5774, nj usa, 2017) Yağmur, Julide; Cansel, Mehmet; Kurtoğlu, Ertuğrul; Hidayet, Siho; Açıkgöz, Nusret; Ermis, Necip; Ozyalin, FatmaObjective: To evaluate left atrial (LA) volume and functions in obese subjects using real time three-dimensional echocardiography (RT3DE) and also the relationship between LA mechanical functions and N-terminal pro-atrial natriuretic peptide (NT-proANP). Methods: This study included 40 obese (26 females and 14 males, mean age 51.9 years) and 40 normal weight subjects (23 females and 16 males, mean age 53.5 years) with normal coronary angiograms. All the study participants underwent RT3DE to assess LA volume and mechanical function. Plasma NT-proANP was determined by ELISA method. Results: There was no significant difference between groups in left ventricular (LV) diameters and ejection fraction, which reflect LV systolic function. However, transmitral deceleration time, isovolumetric relaxation time, and peak late diastolic tissue Doppler velocity values, which reflect LV diastolic function, were found to be significantly higher in obese subjects when compared with controls. LA maximum volume (LAVmax), LAVmax index (LAVI), LA minimal volume (LAVmin), before atrial contraction volume (LAVpreA), LA active emptying volume, LA total emptying volume, and LA active emptying fraction, which reflect LA reservoir and pump functions, were also higher in obese subjects when compared with controls. LA passive emptying fraction was significantly lower in obese subjects than in controls. NT-proANP levels were similar between groups. There were positive correlations between NT-proANP level and LAVI, LAVmax, LAVmin, LAVpreA, and LA total and active emptying volumes. Conclusions: Left atrial mechanical functions and volumes are impaired in obese subjects. These findings may be regarded as early markers of subclinical cardiac failure in obese subjects who have not yet exhibited any clinical evidence of cardiovascular disease.Öğe Assessment of left atrial volume and function in patients with Sjogren's syndrome using three-dimensional echocardiography(Wiley, 2020) Hidayet, Siho; Yagmur, Julide; Karaca, Yucel; Bayramoglu, Adil; Yolbas, Servet; Hidayet, Emine; Ulutas, ZeynepObjective We used real time, three-dimensional transthoracic echocardiography (3DTTE) to evaluate left atrial (LA) volume and mechanical function in patients with primary Sjogren's syndrome (SS). Methods We prospectively included 42 consecutive patients with primary SS and 42 controls who were similar in terms of basal characteristics. 3DTTE was used to assess LA function. Results Maximum LA volume, minimum LA volume, pre-atrial contraction LA volume, LA Active Stroke Volume (ASV), LA Total Stroke Volume (TSV), maximal left atrial volume index (LAVImax), Left atrial pre-contraction volume index, and Left atrial minimum volume index, ASV index, and TSV index were significantly higher in the SS group, and the LA Total Emptying Fraction, LA Expansion Index, and LA Passive Emptying Fraction were significantly lower. Although the active emptying fraction was higher in the SS group, the difference was not statistically significant. LAVImax was positive correlated with disease duration (r = .753). Conclusion Left atrial function is impaired in SS patients and serves as an early marker of subclinical cardiac involvement.Öğe Assessment of left atrial volume and mechanical functions using real-time three-dimensional echocardiography in patients with mitral annular calcification(Turkish Soc Cardiology, 2016) Bayramoglu, Adil; Tasolar, Hakan; Otlu, Yilmaz Omur; Hidayet, Siho; Kurt, Fuat; Dogan, Adil; Pekdemir, HasanObjective: Mitral annular calcification (MAC) is degeneration of the fibrous annular ring of the mitral valve. Left atrial (LA) function and volume have been evaluated by many methods; however, none have used real-time three-dimensional echocardiography (RT3DE) in patients with MAC. Our study is the first to evaluate LA volume and mechanical function using RT3DE in patients with MAC. Methods: Our study was a prospective cross-sectional study. In total, 32 patients with echocardiographic evidence of MAC and 30 volunteers without MAC were enrolled in the study. Kolmogorov-Smirnov test, Student's t-test, Mann-Whitney U test, chi-square test, Pearson's correlation test, and multiple linear regression analyses were used in this study. Results: LA diameter was significantly higher in patients with MAC (38.5 +/- 3.8 vs. 31.1 +/- 2.9, p<0.001). Maximum LA volume (49.6 +/- 11.2 vs. 35.6 +/- 2.5, p<0.001), minimum LA volume (23.8 +/- 7.9 vs. 12.6 +/- 2.3, p<0.001), and LA volume index (LAVI) (26.9 +/- 6.1 vs. 20.5 +/- 2.4, p<0.001) were also higher in the MAC group. LAVI was correlated with age (p<0.001), blood urea nitrogen levels (p=0.089), total cholesterol levels (p=0.055), left ventricular systolic myocardial velocity (p=0.048), E/A ratio (p<0.001), and MAC (p<0.001). Multiple linear regression analyses revealed that age (beta=0.390, p<0.001) and MAC (beta=0.527, p<0.001) were independent predictors of LAVI. Conclusion: We found that LA mechanical function was impaired in patients with MAC. Furthermore, age and MAC were independent predictors of increased LAVI according to our RT3DE examination.Öğe Association between pan-immune-inflammation value and no-reflow in patients with ST elevation myocardial infarction undergoing percutaneous coronary intervention(Taylor & Francis Ltd, 2023) Bayramoglu, Adil; Hidayet, SihoNoreflow is a condition associated with a poor prognosis in ST segment elevation myocardial infarction patients. It has been shown that many inflammatory markers and index such as procalcitonin, C-reactive protein, neutrophil to lymphocyte ratio, systemic immune inflammatory index (SII), are associated with noreflow. We used a brand-new index pan-immune-inflammation value (PIV) to retrospectively evaluate the relationship between PIV and noreflow. A total of 1212 patients were included for analysis. Noreflow was observed in 145 patients. In multivariate analysis, PIV (odds ratio (OR): 1.025; [1.002-1.115], p < 0.001), baseline ejection fraction (OR: 0.963; [0.934-0.993], p = 0.015), stent length (OR: 1.032; [1.010-1.054], p = 0.004), age (OR: 1.034; [1.014-1.053], p = 0.001) and pain to PCI time (OR: 1.003 [1.002-1.005], p < 0.001) were observed to be the independent predictors of noreflow. ROC curve analysis showed that the best cut off value of PIV for predicting noreflow was & GE;889 with 77.2% sensitivity and 77.5% specificity (AUC, 0.828; 95% CI [0.806-0.849]). A ROC curve comparison analysis was performed to compare PIV and SII. The predictive power of PIV was higher than SII (differences between areas: 0.154; p < 0.001). According to our findings, an increase in PIV is an independent predictor of noreflow in patients with STEMI.Öğe Bilateral Coronary Artery Fistulas Draining Into Pulmonary Artery(Derman Medical Publ, 2015) Otlu, Yilmaz Omur; Bayramoglu, Adil; Hidayet, Siho[Abstract Not Available]Öğe Bone Marrow Transplantation as a Rare Cause of Pulmonary Arterial Hypertension(Kare Publ, 2023) Ulutas, Zeynep; Ermis, Hilal; Ermis, Necip; Berber, Ilhami; Hidayet, SihoThe development of pulmonary arterial hypertension after bone marrow transplantation (BMT) is a rare but serious complication. In this case report, we presented the development of pulmonary arterial hypertension in a 22-year-old woman who underwent BMT due to aplastic anemia. Her symptoms on admission included shortness of breath, palpitations and fatigue. Pulmonary hypertension was classified with right heart catheterization as pul monary arterial hypertension. The patient's laboratory, echocardiographic and hemodynamic findings improved with pulmonary arterial hypertension-specific treatment. Pul monary arterial hypertension should be considered in the differ ential diagnosis of BMT patients with 'unexplained' hypoxemia or respiratory distress.Öğe Coexistence of Single Coronary Artery Anomaly and Aortic Arch Anomaly(Derman Medical Publ, 2015) Otlu, Yilmaz Omur; Oner, Serkan; Hidayet, Siho[Abstract Not Available]Öğe Coexistence of Sinus Valsalva Aneurysm Rupture and Atrial Septal Defect(Excerpta Medica Inc-Elsevier Science Inc, 2014) Hidayet, Siho; Otlu, Yilmaz Omur; Bayramoglu, Adil; Ulutas, Zeynep; Ermis, Necip; Ozdemir, Ramazan[Abstract Not Available]Öğe Comparison of left atrial volume and function in non-dipper versus dipper hypertensives: A real-time three-dimensional echocardiography study(Kare Publ, 2016) Ermis, Necip; Otlu, Yilmaz Omur; Afsin, Abdulmecit; Hidayet, Siho; Acikgoz, Nusret; Cansel, Mehmet; Yagmur, JulideObjective: Non-dipper hypertension is associated with an increased cardiovascular morbidity and mortality. Besides this, the left atrial (LA) size and functions are accepted to be prognostic factors in various cardiovascular diseases. In this study, we aimed to evaluate the effect of nondipper hypertension on LA volume and functions using real-time three-dimensional echocardiography (RT3-DE). Methods: Forty dipper and 52 non-dipper hypertensives enrolled in this prospective cross-sectional study. Patients with any comorbidities that have a potential for causing structural cardiac alterations were excluded. Two-dimensional echocardiography (2-DE) and RT3-DE were performed to assess LA volumes and functions. The statistical tests used in this study were Shapiro-Wilk's test, Student's t-test, Mann-Whitney U test, chi-square test, Spearman's test, and Pearson's correlation test. Results: LA minimal volume, LA volume before LA contraction, and LA total systolic volume were higher in non-dipper hypertensives than in dipper hypertensives (p<0.001, p=0.003, and p=0.03, respectively). Only, the 2-DE measurements of interventricular septal thickness and E/Em ratio were higher in non-dipper hypertensives (p=0.001 and p=0.03, respectively). There was a moderate correlation between LA minimal volume and LA volume before LA contraction with E/Em (r=0.31, p=0.007 and r=0.32, p=0.005, respectively). Conclusion: Although LA volume and passive LA systolic functions measured by RT3-DE are significantly increased in non-dipper hypertensives, the alterations in active LA systolic functions are not prominent. RT-3DE may be used to define LA volume and function alterations in conditions that have capabilities of adverse cardiac remodeling such as systemic hypertension.Öğe Effects of colchicine on cardiac functions Reply(Turkish Soc Cardiology, 2019) Hidayet, Siho; Demir, Vahit; Turan, Yasar; Gurel, Gulhan; Tasolar, Mehmet Hakan[Abstract Not Available]Öğe Evaluation of left atrial volume and functions by 3D echocardiography in patients with prediabetes and investigation of its correlation with NT-pro ANP levels(2022) Eyyüpkoca, Ferhat; Hidayet, Siho; Ozyalin, Fatma; Bayramoğlu, Adil; Altıntaş, Mehmet Sait; Akaycan, JulideBackground: An increased burden of cardiovascular disease is observed in prediabetes compared to normoglycemic. In this study, we aimed to evaluate left atrium (LA) volume indices and mechanical functions in prediabetes patients by real-time three- dimensional echocardiography (3DE) and examine the relationship of these parameters with N-terminal pro-atrial natriuretic peptide (NT-pro-ANP) levels. Methods: 41 patients diagnosed with prediabetes by the oral glucose tolerance test in the endocrinology outpatient clinic and 43 healthy controls were included in this study. We evaluated the volume indices and mechanical functions of the LA using 3DE. Plasma NT-proANP was evaluated by the enzyme-linked immunosorbent assay method. Results: Median NT-pro-ANP level was higher in the prediabetes group than the control group (1.5 vs 0.7 nmol/L, p<0.001). Levels of LA volume index (LAVI), minimum and maximum of LA volume (Vmin, Vmax; respectively), pre- atrial contraction volume (VpreA), active emptying fraction, and total and active emptying volume, each reflects reservoir and pump functions of LA, were higher in the prediabetes group. In contrast, the LA passive emptying fraction (PEF) level was lower (p<0.05). There was a positive correlation between levels of NT-pro-ANP and Vmax (r= 0.352, p=0.024), Vmin (r= 0.563, p<0.001), VpreA (r= 0.504, p<0.001), and LAVI (r= 0.338, p=0.031), while negative correlation existed between levels of NT-pro-ANP and total emptying fraction (r = -0.522, p<0.001) and PEF (r= -0.349, p=0.025) was found. Conclusion: LA volume and mechanical functions are impaired in prediabetes patients, and this deterioration was positively correlated with NT pro-ANP levels. The current findings demonstrate that cardiac structural deterioration in prediabetes patients is just initiated before overt diabetes onset.Öğe Evaluation of myocardial performance index in smokers(2020) Hidayet, SihoAbstract: Aim: The aim of this study was to evaluate MPI and left ventricular (LV) functions in patients without cardiac risk factors except smoking. Smoking is associated with increased cardiovascular events. Myocardial performance index (MPI) is a noninvasive tissue doppler technique that provides information about left ventricular systolic and diastolic functions. Material and Methods: A total of 50 smokers and 50 healthy volunteers were consequently included in the study. All participants underwent echocardiographic examinations, including MPI measurements. Results: We found that MPI values were significantly higher in the smoker group (0.52 ± 0.08, 0.42 ± 0.07, p< 0.001). E wave (0.73 ± 0.18, 0.84 ± 0.25, p = 0.018), IVRT (77.52 ± 11.90, 61.80 ± 12.85, p <0.001), IVCT (60.84 ± 15.67, 53.16 ± 10.68, p = 0.005) values were significantly lower in the control group.There was a positive correlation between packet-year and MPI (r = 0.525, p<0.001) Conclusion: In our study, we observed increased MPI in smokers, which was shown to be associated with left ventricular function. We think that MPI could be used as an easy method to determine subclinical left ventricular dysfunction in healthy smokers.Öğe Evaluation of myocardial performance index in smokers(2020) Hidayet, SihoAim: The aim of this study was to evaluate MPI and left ventricular (LV) functions in patients without cardiac risk factors except smoking. Smoking is associated with increased cardiovascular events. Myocardial performance index (MPI) is a noninvasive tissue doppler technique that provides information about left ventricular systolic and diastolic functions.Material and Methods: A total of 50 smokers and 50 healthy volunteers were consequently included in the study. All participants underwent echocardiographic examinations, including MPI measurements.Results: We found that MPI values were significantly higher in the smoker group (0.52 ± 0.08, 0.42 ± 0.07, p 0.001). E wave (0.73 ± 0.18, 0.84 ± 0.25, p = 0.018), IVRT (77.52 ± 11.90, 61.80 ± 12.85, p 0.001), IVCT (60.84 ± 15.67, 53.16 ± 10.68, p = 0.005) values were significantly lower in the control group.There was a positive correlation between packet-year and MPI (r = 0.525, p0.001)Conclusion: In our study, we observed increased MPI in smokers, which was shown to be associated with left ventricular function. We think that MPI could be used as an easy method to determine subclinical left ventricular dysfunction in healthy smokers.Öğe Evaluation of pulmonary artery stiffness and right ventricle functions in polycythemia vera patients by transthoracic echocardiography(Wiley, 2023) Karaca, Yuecel; Hidayet, Siho; Bayramoglu, Adil; Yildirim, Erkan; Berber, Ilhami; Guven, Fatih; Yigit, YakupIntroductionPolycythemia vera (PV) is known to be a subgroup of chronic myeloproliferative neoplasms and is recognized as a cause of pulmonary hypertension (PH). Pulmonary artery stiffness (PAS) is a relatively new noninvasive echocardiographic index developed to evaluate the structural features and functions of the pulmonary vascular bed. In this study, we aimed to evaluate right ventricular (RV) functions and PAS in PV patients and healthy controls. MethodsA group of 65 consecutive PV patients and 40 healthy controls were included in the study. RV global longitudinal strain (RVGLS) and RV free wall longitudinal strain were (RVFwLS) evaluated using two-dimensional (2D) strain echocardiography. RV volume, systolic and diastolic functions were evaluated with three-dimensional (3D) echocardiography. PAS was calculated using the maximum frequency shift (MFS) and acceleration time of the pulmonary artery flow trace. ResultsPAS values were significantly higher in the PV group than in the control group (25.2 +/- 5.2 vs. 18.2 +/- 4.2, p < .001). We found that tricuspid annular plane systolic excursion (TAPSE) (p < .001), RV fractional area change (p < .001) and RV ejection fraction (p < .001) measurements evaluated by 3D echocardiography were significantly lower in the PV group. ConclusionIn our study, PAS values were higher in PV patients than in the healthy control group. Patients with PV may have subclinical RV dysfunction, and PAS value can be used in the early diagnosis of PH and RV dysfunction in this patient group.Öğe Evaluation of repolarization dispersion in patients with idiopathic pulmonary fibrosis(2022) Eyyüpkoca, Ferhat; Hidayet, Siho; Altıntaş, Mehmet Sait; Yüksel, Yasin; Demirkol, Barış; Çetinkaya, ErdoğanIdiopathic pulmonary fibrosis (IPF) is a serious lung disease of unknown etiology and characterized by interstitial fibrosis. The patients usually present with potentially fatal cardiac arrhythmias. This study aimed to investigate indicators of arrhythmia based on electrocardiography (ECG) in patients with IPF. ECG indicators of ventricular depolarization (VD) and repolarization (VR) (QT, QTc, QTd, QTdc, Tp-e, JT and JTc intervals, Tp-e / QT ratio, Tp-e / QTc ratio, Tp-e / JT ratio, and Tp-e / JTc ratio) were analyzed retrospectively in patients with IPF (n:52) and compared with the healthy control group (n:52). The mean QRS interval was lower in patients with IPF compared to the control group, indicators of VD and VR were higher in patients with IPF compared to the control group (p < 0.05). A positive correlation was found between indicators of VD and VR and inflammation markers (CRP and cTn-I) (p < 0.05). We found that indicators of VD and VR were higher in patients with IPF and that is positively correlated with inflammatory markers. Inflammation in cases of IPF may be associated with the development of malignant or chronic cardiac arrhythmias.Öğe Evaluation of the Effect of Transcatheter Aortic Valve Implantation on Left Ventricular Function by 4-Dimensional Echocardiography(Kare Publ, 2023) Bayramoglu, Adil; Ulutas, Zeynep; Akaycan, Julide; Hidayet, Siho; Tasolar, Hakan; Cansel, Mehmet; Ermis, NecipObjective: Beneficial effects of transaortic valve implantation on left ventricular hemodyna-mics and prognosis of patients have been demonstrated. Although left ventricular systolic and diastolic function following transaortic valve implantation procedure have been examined in previous studies, 4-dimensional echocardiographic parameters have not been extensively studied, especially in patients with preserved ejection fraction aortic stenosis. In our study, we planned to evaluate the effect of transaortic valve implantation on myocardial deformation using 4-dimensional echocardiography. Methods: A total of 60 consecutive patients who underwent transaortic valve implantation for severe aortic stenosis with preserved ejection fraction were prospectively enrolled in the study. Standard 2-dimensional echocardiography and 4-dimensional echocardiography were per-formed in all patients before and 6 months after the transaortic valve implantation procedure. Results: Six months after valve implantation, significant improvement was observed in global longitudinal strain (P < 0.001), spherical circumferential strain (P = 0.022), global radial strain (P = 0.008), and global area strain (P < 0.001). In the regression analysis, global area strain and absence of diabetes mellitus were determined as independent predictors to show a 10% increase in the left ventricular ejection fraction. Conclusions: In patients with preserved ejection fraction who underwent transaortic valve implantation, left ventricle deformation parameters have improved after 6 months, especially by using 4-dimensional echocardiography. The use of 4-dimensional echocardiography should be more common in daily practice.
