Yazar "Kaplan, Yuksel" seçeneğine göre listele
Listeleniyor 1 - 19 / 19
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Carpal tunnel syndrome in postmenopausal women(Elsevier, 2008) Kaplan, Yuksel; Kurt, Semiha G.; Karaer, HaticeObjective: Hormonal changes that accompany menopause have a significant impact on the nervous and other physiological systems. Our objective was to evaluate the relationship between carpal tunnel syndrome (CTS) and the clinical features of menopause in postmenopausal women, in comparison to age-matched healthy controls. Methods: Overall, 6230 women were seen during the study period. Of these, 5587 were not eligible because they were premenopausal or perimenopausal. 537 women did not meet the criteria used in the study for a diagnosis of idiopathic CTS and were excluded. Finally, one hundred and six patients with CTS and 115 controls were examined. The presence of CTS was confirmed both clinically and electrophysiologically. Socio-demographic variables and reproductive histories were evaluated via a structured interview. Results: In comparison to healthy controls, patients with CTS showed a significantly greater number of pregnancies and an earlier age at menopause. Regarding the type of menopause, patients and controls showed similar frequencies for natural versus surgical menopause. The frequency of natural menopause was significantly higher than that of surgical menopause in both groups. Conclusion: Our results suggest that age at menopause may be a significant factor in the development of CTS. Pregnancy-related hormonal changes may have long-term effects that increase the incidence of CTS in postmenopausal women. (c) 2008 Elsevier B.V. All rights reserved.Öğe Chronic migraine associated with the Chiari type 1 malformation(Elsevier, 2008) Kaplan, Yuksel; Oksuz, ErolObjective: Our objective was to assess the frequency and clinical characteristics of migraine in the patients with CM-1. Methods: We analyzed migraine in 73 patients with CM-1. Migraine was classified according to the new International Headache Society criteria. We did not include patients who had intracranial, parenchymal, or cervical lesions other than CM-1 on brain and cervical magnetic resonance imaging Results: Of the 73 patients diagnosed as having CM-1, 11 (15.06%) had migraines; of them, 8 (10.95%) had chronic migraines, 2 (2.73%) had migraines with auras, and 1 (1.36%) had migraines without auras. The patients who had both migraines and CM- I (group 1) were compared regarding clinical characteristics and demographic features to the control group having chronic migraines. The control group comprised subjects free of CM-1. Onset age of pain was earlier and the frequency of headache days per month, baseline pain intensity, exacerbation of pain intensity, nausea, vomiting, and pain aggravated by physical activity were significantly higher in group 1. Conclusions: Although we found the frequency of migraine to be similar to that in population-based Studies, we detected a threefold increased frequency of chronic migraine in this special population. We believe that CM- I may be a factor associated with chronic migraine. (C) 2008 Elsevier B.V. All rights reserved.Öğe Cluster-Like Headache Associated with Symptomatic Chiari Type 1 Malformation(Galenos Yayincilik, 2014) Kaplan, Yuksel; Kamisli, Ozden[Abstract Not Available]Öğe Combination of myotonic dystrophy and hereditary motor and sensory neuropathy(Elsevier, 2010) Kurt, Semiha; Karaer, Hatice; Kaplan, Yuksel; Akat, Irern; Battaloglu, Esra; Eruslu, Didern; Basak, A. NazliMyotonic Dystrophy Type 1 (DM1) in combination with demyelinating neuropathy is very rare in literature. In this Study, DM1 and demyelinating neuropathy were demonstrated clinically and electromyographically in a 43-year-old female patient from Turkey. In the patient an expanded CTG repeat in the Myotonic Dystrophy Protein Kinase (DMPK) gene was confirmed in combination with a duplication in the Charcot-Marie-Tooth Disease (CMT1A) gene. DM1 was also determined in her 25-year-old son. (C) 2009 Elsevier B.V. All rights reserved.Öğe The Efficacy of Lamotrigine and Levetiracetam Therapy on Serum Lipid Profile in Epilepsy Patients(Kare Publ, 2011) Kamisli, Ozden; Kaplan, Yuksel; Kamisli, Suat; Bakir, Meryem; Ozcan, CemalObjectives: We aimed to investigate the efficacy of two new generation antiepileptics, lamotrigine (LTG) and levetiracetam (LEV), on serum lipid levels, since they are reported to be as effective as classical antiepileptics but with fewer side effects. Methods: We analyzed the files of all epileptic patients who were registered at Inonu University Faculty of Medicine, Turgut Ozal Medical Center, Neurology Department between April 2009 - May 2011 retrospectively. Patients treated with LTG and LEV monotherapy were found and total cholesterol (TC), triglyceride, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) were measured. The patients' data were compared with a control group. Results: Twenty-one patients treated with LTG and 20 patients treated with LEV were included in this study. TC, triglycerides, LDL, VLDL, and HDL values were compared with 21 healthy control subjects. TC, triglycerides, LDL, VLDL, and HDL values showed no statistically significant differences between groups. Conclusion: Neither LEV nor LTG, which are new generation antiepileptics, affected blood lipid levels. We consider that they are safe to use in patients, especially those with atherosclerosis risk.Öğe Episodic Paroxysmal Hemicrania with an Atypical Clinical Presentation: A Case Report and Review of the Literature(Turkish Neurological Soc, 2015) Kaplan, Yuksel; Kamisli, Ozden; Altinayar, SibelParoxysmal hemicrania (PH) is characterized by frequent, short-lasting, severe, unilateral headaches that occur in association with cranial autonomic features. The hallmarks of this syndrome are relatively short attacks and a complete therapeutic response to indomethacin. Although PH has been classified as strictly unilateral headache in association with cranial autonomic features, a few cases have been reported that suggest bilateral PH. We report a case of PH with bilateral distribution and bilateral autonomic features. PH may actually represent a clinical spectrum including different phenotypes.Öğe Evaluation of Cervical Vestibular Evoked Myogenic Potentials in Patients with Migraine(Turkish Neurological Soc, 2013) Kaplan, Yuksel; Tecellioglu, Mehmet; Kamisli, Ozden; Kamisli, Suat; Ozcan, CemalObjective: Recent studies have indicated that the brain stem may contribute in the pathogenesis of migraine through different mechanisms. In addition to being used mainly in otologic diseases, vestibular evoked myogenic potentials (VEMP) testing is also used in neurological diseases affecting the brain stem such as stroke and multipl sclerosis in the literature. Studies involving VEMP testing in patients with migraine are novel and few in number. The purpose of this study was to evaluate whether VEMP values in patients with migraine provide additional information regarding the pathogenesis. Methods: This study included 52 patients with migraine and 52 control subjects. In both patients and controls, VEMP examination was performed using click stimuli, and all responses were recorded for both portions of the sternocleidomastoid muscle. Latency, amplitude and threshold values of the P1-N1 wave were compared between the two groups. Results: The amplitude of the left p1 was 4.47 +/- 3.52 mu v in patients and 6.15 +/- 4.79 mu v in the controls, and the difference was statistically significant. On the left, the average difference in the P1-N1 amplitude was 9.04 +/- 6.13 mu v in patients and 12.03 +/- 7.79 mu v in the controls; this difference was also statistically significant. Conclusion: The available studies on the pathophysiology of migraine show that the brain stem is particularly affected at the upper part. However, VEMP testing is mainly used for the assessment of the neuronal pathway starting from the saccula-macula and finishing at the sternocleidomastoid muscle in the lower brain stem. In this study, the only significant differences in amplitude were found in left-P1 and P1-N1. The results of our study show that in patients with migraine, neuroanatomical structures in the lower brain stem can be asymmetrically affected.Öğe The Evaluation of Premenstrual Dysphoric Disorder Incidence and it's Relationship with Antiepileptic Drugs in Epilepsy Patients(Kare Publ, 2013) Kamisli, Ozden; Kamisli, Suat; Kartalci, Sukru; Bakir, Meryem; Kaplan, Yuksel; Ozcan, CemalObjectives: Premenstrual dysphoric disorder (PMDD) is a condition characterized by psychiatric and somatic symptoms commonly seen in women of childbearing age. There are few studies investigating the prevalence of PMDD in patients with epilepsy. In this study we investigate the frequency of PMDD in epilepsy patients and evaluate the relationship between antiepileptic drugs and PMDD. Methods: The subjects were 93 women with epilepsy and 30 controls. Patients were divided into five subgroups according to their medications as carbamazepine, oxcarbazepine, valproic acide, lamotrigine, and levetiracetam. Each group were examined for the frequency of PMDD. In addition, the incidence of PMDD was compared according to antiepileptic drugs in subgroups. Results: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy group, especially temporal lobe epilepsy, has a higher incidence of PMDD, but similar results were also found in women without epilepsy. Looking at the relationship between antiepileptic treatments and PMDD, patients treated with lamotrigine had the lowest frequency. Conclusion: The frequency of PMDD was similar in patients with and without epilepsy. Focal epilepsy patients, especially temporal lobe epilepsy patients, had a higher incidence of PMDD. The LTG group had the lowest rate of PMDD. In terms of PMDD, LTG may be beneficial for young women with epilepsy.Öğe Hot Water Epilepsy: Is It An Autosomal Dominant Inherited Disorder?(Kare Publ, 2014) Kurt, Semiha; Yigit, Serbulent; Unaldi, Hatice Karaer; Kaplan, Yuksel; Aksoy, Durdane; Cevik, Betul; Solmaz, VolkanObjectives: Hot water epilepsy (HWE), also called as bathing epilepsy is a reflex epilepsy in which seizures are triggered by the stimulus of bathing in hot water. The relationship between epilepsy syndromes and genetic have been known for a long time. In this study, we aimed to determine the inheritance pattern of the five HWE cases with a positive family history. Methods: Pedigrees of the five index cases had a positive family history were drawn and their family members were interviewed. Age, sex, seizure types (classified according to ILAE Task Force on Classification and Terminology), seizure frequency, neurological examination findings, if available EEG and MRI results of patients were recorded. Results: Sixteen patients from five families were included in the study. The patients (ten male, six female) were between 15 and 73 years of age. Four families without consanguineous marriage had patients with HWE at least two generations. One family with consanguineous marriage had with HWE two generations. Conclusion: When analyzed pedigrees, except one family, the disease appears at least two generation in the same family without consanguineous marriage. Our data suggest that the HWE may be an autosomal dominant inherited disorder with low- penetrance and lowexpressivity.Öğe Intra-Familial Incidence and Characteristics of Hot Water Epilepsy(Cambridge Univ Press, 2009) Kaplan, Yuksel; Kurt, Semiha G.; Karaer, Hatice; Sarikaya, Basar; Bebek, NersesObjective: To assess the clinical features of several members of the same family diagnosed with both hot water epilepsy (HWE) and cerebral lesions. Methods: Age at onset and types of seizure, precipitating factors, EEG findings, and neuroimages were evaluated. Results: The family consisted of' six generations, including one consanguineous parent. Of eight family members diagnosed with epilepsy, seven suffered from HWE. Age at onset of seizures ranged within childhood. Seven patients with HWE experienced complex partial seizures, with or without secondary generalization; one experienced simple partial seizures as well as complex partial seizures. Three patients experienced spontaneous seizures as well as HWE. Interictal EEG revealed abnormalities in two patients. Magnetic resonance imaging revealed cerebral lesions in one patient, probably attributable to ischemic changes. Magnetic resonance images were consistent with findings of ischemic gliosis in two patients, and either demyelinating or ischemic gliosis in one patient. Conclusions: Descriptions of HWE families with different ethnic backgrounds may permit more definite conclusions regarding the mechanisms epileptogenesis, and the genetic defects that underlie this disease.Öğe Investigation of neuromuscular transmission in patients with chronic obstructive pulmonary disease: A preliminary report(European Respiratory Soc Journals Ltd, 2012) Kaplan, Yuksel; Gulbas, Gazi; Ermis, Hilal; Kamisli, Ozden; Kamisli, Suat; Ozcan, Cemal[Abstract Not Available]Öğe Ischemic stroke in young adults: Gender-based differences(2020) Algul, Fatma Ebru; Kaplan, YukselAbstract: Stroke is becoming a growingly more prevalent and significant public health problem among young adults around the world. Modifiable lifestyle-related risk factors are the most common cause of stroke in young adults. The aim of this study was to perform a gender-based evaluation of risk factors, stroke subtypes, severity of stroke, level of dependency at hospital discharge, and length of hospital stay among young patients with ischemic stroke in our region. The retrospective study included patients that were diagnosed with ischemic stroke based on patient history and clinical and radiographic findings at Inonu University Medical School Neurology Department between 2015 and 2018. The patients were divided based on gender and the two groups were compared with regard to age, gender, prior stroke, risk factors, neurologic deficits at hospital admission, etiology, radiographic localization, length of hospital stay, and the levels of disability and dependency at hospital discharge were reviewed for each patient. The study included a total of 105 patients diagnosed with ischemic stroke, comprising 65 (61.9%) men and 40 (38.1%) women. Mean age was 46.02±7.29 years in men and 41.18±8.2 years in women and a significant difference was observed between the two groups (p=0.002). The incidence of diabetes mellitus (DM), myocardial infarction (MI), and smoking was significantly higher in men compared to women (p=0.008, p=0.001, and p<0.001, respectively), whereas the incidence of mitral stenosis was significantly higher in women compared to men (p=0.0019). The results indicated that modifiable lifestyle-related risk factors are the most common cause of stroke in young adults and the significance of risk factors associated with stroke in young individuals differs between genders. Future studies with larger patient populations are needed to identify further risk factors and precautions for stroke in young adults.Öğe Neuromuscular transmission in hypoxemic patients with chronic obstructive pulmonary disease(Elsevier, 2013) Gulbas, Gazi; Kaplan, Yuksel; Kamisli, Ozden; Ermis, Hilal; Kamisli, Suat; Ozcan, CemalMany studies have focused on the systemic effects of chronic obstructive pulmonary disease (COPD), but none has examined neuromuscular junction transmission (NMT). We evaluated NMT dysfunction using single-fiber electromyography (SFEMG) in patients with COPD. Twenty patients with COPD and 20 age-matched healthy controls were included in the study. All patients and controls underwent SFEMG. Abnormal NMT was found in seven of 20 patients (35%), but in none of the control subjects. The COPD patients were subgrouped according to the presence of hypoxemia. The patients with normoxemia were classified as Group 1, and the patients with hypoxemia were classified as Group 2. Abnormal NMT was found in six patients in Group 2 and in one in Group 1. While there was significant difference in terms of abnormal NMT between Group 2 and the controls, there was none between Group 1 and the controls. Our results show that NMT abnormalities can be present in hypoxemic patients with COPD. (C) 2013 Elsevier B.V. All rights reserved.Öğe Peduncular Hallucinosis due to Multiple Sclerosis: A Case Report(Turkish Neurological Soc, 2013) Kamisli, Ozden; Kaplan, Yuksel; Kamisli, Suat; Ozcan, CemalPeduncular hallucinosis is a snydrome characterized by vivid, colored visual hallucinations due to brain stem and thalamic involvement. The etiology of peduncular hallucinosis mostly involves lesions of vascular nature and infections. The cases of peduncular hallusinosis due to multiple sclerosis is very rare in the literature. In this report we presented a peduncular hallucinosis case who is a 46 year old woman with multiple sclerosis diagnosis.Öğe Prevalence and Features Associated With Restless Leg Syndrome in Postmenopausal Females(Journal Neurological Sciences, 2014) Unaldi Karaer, Hatice; Kaplan, Yuksel; Kurt, Semiha; Demirturk, FazliBackground: Animal and human studies have shown that estrogen modulates dopaminergic activity. The hypoestrogenic state associated with menopause, characterized by a decreased ovarian follicular response to gonadotropins and estrogen, affects the nervous system at multiple anatomical or functional sites. Aims: We investigated the prevalence of restless leg syndrome (RLS) in postmenopausal females and assessed the relationship between RLS and the clinical features of menopause. Methods: We enrolled 523 menopausal females in the study. Of those, 334 (63.86%) did not meet the inclusion criteria and were excluded. Of the remaining 189 postmenopausal patients, 73 met all of the diagnostic criteria for RLS; however, 47 of those had at least one factor related to secondary RLS and were excluded from the study. The remaining 26 (18.3%) postmenopausal patients with idiopathic RLS were categorized as group 1. The control group included 56 postmenopausal females free of RLS and matched by age (+2 years) to group 1. Results: Onset age of menopause was earlier and surgical menopause was more frequent in group 1. The Pearson's correlation test revealed a strong and significant correlation between the onset ages of menopause and RLS. Conclusions: Estrogen receptors are widely distributed throughout the central and peripheral nervous systems. Estrogen modulates dopaminergic activity in the nigrostriatal system. Menopause is characterized by hypoestrogenemia, and may be a risk factor for the development or worsening of RLS symptoms.Öğe The Relationship Between Boston Questionnaire and Electrophysiological Findings in Carpal Tunnel Syndrome(Galenos Yayincilik, 2010) Kurt, Semiha; Cevik, Betul; Kaplan, Yuksel; Karaer, Hatice; Erkorkmaz, UnalObjective: Boston Questionnaire (BQ) is a method, which is used for assessment of severity of symptoms and functional status in carpal tunnel syndrome (CTS). In this study, we aimed to investigate the relationship between electrophysiological findings and scores of BQ including functional capacity and severity of symptoms. In addition, the effect of body weight on this relationship was investigated. Methods: 98 consecutive patients, who were referred to our electrophysiology laboratory with prediagnosis of CTS and had no systemic disease such as diabetes mellitus, rheumatoid arthritis, and thyroid disease, were included this study. A detailed neurological examination was performed to all patients. Median and ulnar nerve conduction studies were carried out. The patients with Body Mass Index (BMI) exceeding 30 were considered obese. BQ was applied to all patients. Results: There was a weak but a significant correlation between the results of the nerve conduction studies and the functional capacity scores. This correlation was not found in obese patients. No correlation between symptom severity scores and the findings of nerve conduction studies was determined. Conclusion: In the literature, there are a small number of studies that investigated the relationship between BQ scores and electrophysiological findings. The relationship was detected at some of there where as was not at remainders. In our study, even though the results of the nerve conduction studies were found to be correlated with functional capacity scores, there was no correlation between symptom severity scores and nerve conduction study findings. Although this relationship was found to be more significant in the non-obese patients, no relationship was observed in obese patients. (Archives of Neuropsychiatry 2010;47:237-40)Öğe Risk Factors For Diabetic Polyneuropathy(Aves, 2014) Kaplan, Yuksel; Kurt, Semiha; Unaldi, Hatice Karaer; Erkorkmaz, UnalIntroduction: The aim of this study was to investigate the risk factors for distal symmetric sensory-motor polyneuropathy (DSP) in patients with type 2 diabetes mellitus (DM). Methods: Sixty seven patients with type 2 DM (33 males and 34 females) were included in the study. In addition to a detailed neurological examination, the Michigan Neuropathy Screening Instrument was administered to all patients and their total neuropathy scores were calculated. Nerve conduction examinations were performed for all patients. Results: The mean age of the patients was 52.83 +/-.87 years. The mean glycosylated hemoglobin (HbA1C) value was 8.56 +/- 2.07% (normal: 3-6.5%). The total neuropathy score significantly correlated with diabetes duration, hypertension, retinopathy, and HbA1C. Conclusion: This study confirms the previous reports regarding the association of neuropathy with poor glycaemic control and duration of the disease. The association of neuropathy with retinopathy and hypertension is important.Öğe 'Total Anterior Circulation Infarct' to Assess Gender Differences(Aves, 2013) Inanc, Yusuf; Kaplan, Yuksel; Kamisli, Ozden; Kamisli, Suat; Ozcan, CemalObjective: We evaluated the risk factors, demographic, clinical and etiological characteristics of patients with total anterior circulation infarct (TACO. In this study, we aimed to elucidate the impact of gender-based differences on these parameters. Methods: A total of 74 patients with TACI were enrolled in the study. 38 (51.3%) patients were female and 36 (48.6%) were male. We compared the age, previous stroke, prestroke modified Rankin Scale (mRS) scores, National Health Interview Survey (NIHSS) scores according to The National Institute of Health Stroke scale, Glasgow coma score (GCS) and mRS at the time of admission, risk factors, etiological subtypes of stroke, topography of infarcts, the rate of neurologic and systemic complications, length of hospital stay, the rate of death, and the causes of mortality between genders. Results: The frequency of recurrent stroke, the frequency of diabetes mellitus and systemic complications were significantly more common in females. Female patients had also higher median length of hospital stay than men. Conclusion: The result of the present study indicated that female gender has a negative effect on clinical outcome of TACI.Öğe Toxocara Seroprevalence in Patients with Idiopathic Parkinson's Disease: Chance Association or Coincidence?(Hindawi Ltd, 2013) Celik, Tuncay; Kaplan, Yuksel; Atas, Eser; Oztuna, Derya; Berilgen, SaidMost cases of idiopathic Parkinson disease (IPD) are believed to be due to a combination of genetic and environmental factors. The purpose of this study is to investigate the relationship between toxocariasis and Parkinson disease (PD). Patients were selected from people who were admitted to the Movement Disorders Branch, Neurology Department of Elazig University Faculty of Medicine Elazig, Turkey. We studied specific IgG antibodies against Toxocara canis (T. canis) in 50 patients with idiopathic Parkinson and 50 healthy volunteers. We investigated the clinical history of three patients infected with T. canis. We also studied specific IgG antibodies against Toxoplasma gondii in these groups. Antibodies anti-Toxocara canis were found in 3 idiopathic PD (6%) (P = 0.121) and antibody titer was not found in control. A patient had history of the presence of dog in current dog ownership. We did not detect any statistically significant association between T. canis and IPD. But, we believe that further comprehensive studies are required for understanding whether there is a causal relation between toxocariasis and PD. We didn't find possible association between Toxoplasma gondii and IPD (P = 0.617).
