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Adneksiyel kitleyi taklit eden ektopik pelvik böbrek
(Türk Jinekoloji ve Obstetrik Derneği Dergisi, 2012) Yılmaz, Ercan; Yavuz, Şimşek; Karaer, Abdullah; Çelik, Ebru; Türkçüoğlu, Ilgın; Çağdaş, Doğan; Çelik, Önder; Aydın, Engin
Öz: Ektopik pelvik böbrek, genitoüriner sistem anomalisi olan kadınlarda yaygın gelişim anomalisidir ve klinikte adneksiyel patolojileri taklit etmektedir. Bu olgu sunumunda hidronefroz gelişen bir pelvik ektopik böbrek adneksiyel kistik patolojiyi taklit etmektedir.
Amniotic fluid urocortin-1 concentrations for the prediction of preterm delivery
(Wiley, 2013) Karaer, Abdullah; Celik, Ebru; Celik, Onder; Simsek, Omer Yavuz; Ozerol, Ibrahim Halil; Yilmaz, Ercan; Turkcuoglu, Ilgin
Aim The aim of this study was to analyze whether urocortin-1 concentration in midtrimester amniotic fluid could serve as an indicative marker of preterm labor. Material and Methods A retrospective cohort study was conducted. Urocortin-1 concentrations in midtrimester amniotic fluid were measured in 22 pregnant women with preterm deliveries and 45 women who delivered at term using enzyme-linked immunosorbent assay. Results The median amniotic fluid urocortin-1 concentration was significantly lower in the women with preterm birth (40.06pg/mL; range, 13.77-67.58pg/mL) than in the women who gave birth at term (49.56pg/mL; range, 26.25-175.9pg/mL; P=0.022). The result of receiver-operator curve analysis indicates that an amniotic fluid urocortin-1 concentration57.88pg/mL had an area under the curve of 0.673 (95% confidence interval, 0.55-0.78; P=0.01) with a sensitivity of 81.8%, specificity of 40.0%, positive predictive value of 40%, and a negative predictive value of 82% in identifying which of the patients subsequently delivered prematurely. Conclusions These results suggest that low urocortin-1 concentration in midtrimester amniotic fluid could be used as an indicative marker of preterm birth.
Assessment of anxiety and depression levels of pregnant women with hyperemesis gravidarum in a case-control study
(Journal of the Turkish-German Gynecological Association, 2012) Şimşek, Yavuz; Çelik, Önder; Yılmaz, Ercan; Karaer, Abdullah; Yıldırım, Engin; Yoloğlu, Saim
Öz: Amaç: Bu yazıda Beck anksiyete ve depresyon skorlama sistemi kullanılarak hiperemezisli gebelerde anksiyete ve depresyon düzeylerinin araştırılması amaçlandı. Gereç ve Yöntemler: Çalışma için 1. trimesterdeki 86 gebeyi içeren bir olgu-kontrol çalışması yapıldı. Hiperemezis gravidarumlu 41 hasta ve sağlıklı kontrol grubu olarak 45 gebe dahil edildi. Gruplar yaş, parite ve vücut kitle indeksi değerleri açısından eşleştirildi. Tüm hastalardan serum TSH ve hCG düzeylerini de içeren bazal laboratuvar tetkikleri istendi. Bulgular: Gruplar arasında serum potasyum düzeyinin hiperemezisli olgularda anlamlı olarak düşük olması (p=0.039) dışında demografik, obstetrik ve laboratuvar değerleri açısından farklılık yoktu. Hiperemezisli hastaların depresyon ve anksiyete skorları kontrol grubuna göre anlamlı olarak daha yüksekti (Sırasıyla p=0.0001 ve p=0.049). Sonuç: Artmış anksiyete ve depresyon düzeyleri hiperemezis gravidarumun patogenezinde rol oynayabilir. Bu hastaların takip ve tedavilerinde ekstra psikolojik destek gerekebilir. (J Turkish-German Gynecol Assoc 2012; 13: 32-6)
Assessment of early decline in the percentage of ?-hCG values between days 0 and 4 after methotrexate therapy in ectopic pregnancy for the prediction of treatment success
(Journal of the Turkish-German Gynecological Association, 2013) Çelik, Ebru; Türkçüoğlu, Ilgın; Karaer, Abdullah; Kırıcı, Pınar; Eraslan, Sevil
Öz: Amaç: Ektopik gebeliklerin tedavisinde methotraksat tedavisinin başarısını belirlemede beta-human koryonik gonadotropin (?-hCG) değerlerinin 0-1, 0-4 ve 0-7 günleri arasında yüzde değişimlerini değerlendirmek. Gereç ve Yöntemler: Ocak 2011 ile Agustos 2012 tarihleri arasında ektopik gebelik nedeniyle tanı alan ve tek doz metotreksat tedavisi alan 93 olgu çalışmaya dahil edildi. Elektronik ortamda kaydelilen hastaların dosyalarında bulunan tüm bilgiler incelendi. 0-1, 0-4 ve 0-7 günler arasındaki serum ?-hCG seviyelerindeki değişim yüzdeleri her olgu için hesaplandı. Bulgular: Metotreksat tedavisinin başarılı olan olguların %55.8 ve %89.6 da ortanca ?-hCG değerleri 0 ve 4. günler arasında azalmış olarak bulundu. Tedavi öncesindeki ortanca ?-hCG seviyesi tedavinin başarılı olduğu olgularda daha düşük saptanmasına rağmen iki grup arasında istatistiksel olarak bir fark saptanmadı (p=0.11). Sonuç: Serum ?-hCG değerlerindeki 0 ile 4. günler arasındaki düşme olması metoteksat tedavisinin başarısını tahmininde en iyi gösterge olarak ortaya çıkmaktadır, ve tek doz metotreksat ile tedavi edilen ekopik gebeliklerin nihai tedavinin başarısını belirlemek yararlı olacakır. (J Turkish-German Gynecol Assoc 2013; 14: 125-9)
Association of folic acid receptor ? in maternal serum with neural tube defects
(Informa Healthcare, 2014) Celik, Ebru; Karaer, Abdullah; Turkcuoglu, Ilgin; Turhan, Ugur; Gungoren, Arif; Taskapan, Cagatay; Ozyalin, Fatma
Objective: To evaluate whether serum folic receptor alpha levels are changed in women whose previous pregnancies were complicated with neural tube defects (NTDs). Methods: This was a case-control study that included 41 women as the control group who had previously had at least one healthy pregnancy and 37 women as the study group who had a previous pregnancy complicated with NTDs. Blood samples were obtained from all of the participants six weeks after the termination of pregnancy or delivery of a baby. Serum folate receptor alpha concentrations were analyzed using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The mean concentrations of serum folate receptor alpha were significantly lower in the NTD cases compared to those in the control group (p = 0.02). There was no significant difference in mean serum folate titers between the NTD cases and the control group (p = 0.07). Conclusion: Low serum folic acid receptor alpha levels in the current study did not appear to be a regulatory marker of maternal folate homeostasis per se but rather a factor that contributed to the development of NTDs.
Association of low maternal levels of salusins with gestational diabetes mellitus and with small-for-gestational-age fetuses
(Elsevier, 2013) Celik, Ebru; Celik, Onder; Yilmaz, Ercan; Turkcuoglu, Ilgin; Karaer, Abdullah; Turhan, Ugur; Aydin, Suleyman
Objectives: To evaluate maternal and cord serum concentrations of salusin-alpha and salusin-beta in women with gestational diabetes mellitus (GDM) and with small-for-gestational age (SGA) fetuses. Study design: Pregnant women with GDM (n = 25), women with SGA (n = 20) and maternal age-matched normal healthy pregnant subjects (n = 25) participated in the study. Maternal serum and cord blood salusin-alpha and salusin-beta levels at the time of birth were measured using ELISA, and their relation with metabolic parameters was also assessed. Results: Mean concentrations of maternal and fetal serum salusin-alpha in the GDM and SGA groups were significantly lower than those of the controls (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). Mean concentrations of maternal and cord blood salusin-beta also decreased in both the GDM and the SGA groups in comparison to the control group (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). The concentrations of maternal serum salusin-alpha and salusin-beta were strongly positively correlated with the concentrations of cord blood salusin-alpha and salusin-beta (R = 0.92, P < 0.001 and R = 0.94, P < 0.001, respectively). Conclusions: The low levels of maternal serum salusin-alpha and salusin-beta may have negative impact on metabolic disorders and vascular dysfunction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Bernard-Soulier Syndrome from the Perspective of the Obstetrician: A Case Report with a Review of the Literature
(Georg Thieme Verlag Kg, 2023) Saridogan, Erdinc; Onat, Taylan; Duz, Senem Arda; Tuncay, Gorkem; Abdurahmanova, Nuray; Orujova, Lumayat; Karaer, Abdullah
Objective Bernard-Soulier syndrome (BSS) is one of the rare inherited platelet disorders that is characterized by macrothrombocytopenia and adhesion abnormality due to the absence or malfunctioning of the membrane GPIb-IX-V complex. There is no high-quality evidence on obstetric management of BSS owing to its rarity. Here we report an uncomplicated delivery of an adolescent with BSS and review the literature on the topic of BSS and pregnancy.Methods PUBMED, EMBASE, COCHRANE, and Google Scholar databases were searched up to April 2022 without language and year restriction using the terms Bernard Soulier and Pregnancy . The primary objectives were to evaluate maternal and fetal outcomes. The secondary objectives were to analyze pregnancy complications, gestational age at delivery, mode of delivery, administered prophylaxis, treatment approaches, duration of postpartum hospitalization, and the postpartum requirement of blood and blood product.Results The patient was a 19-year-old and 39-week pregnant woman who was diagnosed with BSS at the age of 10 by flow cytometry and genetic analysis. Single donor platelet transfusions and oral tranexamic acid were administered as prophylaxis at the peripartum period. She was delivered by cesarean section due to failure of labor. The postpartum period was uneventful for both mother and neonate. In the literature review, postpartum hemorrhage (PPH) was found in 52.9% (27/51) of deliveries. Late PPH occurred more frequently than early PPH (35.3 and 31.4%, respectively). 49% (25/51) of pregnancies had severe thrombocytopenia, and antepartum hemorrhage was observed in 11.8% (6/51) of those. The platelet count was in close relation to antenatal complications. 64.7% (33/51) of the patients were delivered via cesarean section. PPH and late PPH were found to be more common in those who delivered vaginally compared to those who delivered by caesarean section. It was observed that PPH was less common in women who were given prophylaxis in the peripartum period.Conclusion BSS is an inherited macro-thrombocytopathy that may cause adverse maternal and neonatal outcomes. The optimal mode and timing of delivery remain unclear. A multidisciplinary approach with prophylaxis at the peripartum period should be applied.
Blood Cadmium Concentrations in Women with Ectopic Pregnancy
(Humana Press Inc, 2018) Karaer, Abdullah; Tuncay, Gorkem; Tanrikut, Emrullah; Ozgul, Onur
The purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 mu g/l (interquartile range [IQR] 0.00-0.71) in the women with ectopic pregnancies and 0.34 mu g/l (IQR 0.09-0.59) in the controls. There was no significant association between blood cadmium levels and ectopic pregnancy.
Blood cadmium concentrations in women with ectopic pregnancy
(Humana press ınc, 999 rıvervıew drıve suıte 208, totowa, nj 07512 usa, 2018) Karaer, Abdullah; Tuncay, Gorkem; Tanrikut, Emrullah; Ozgul, Onur
The purpose of this study is to investigate the relationship between the blood level of cadmium and the occurrence of ectopic pregnancy. Forty-one (41) case patients with ectopic pregnancy and 41 uncomplicated intrauterine pregnant patients as controls were recruited. The concentrations of cadmium (Cd) were measured from blood samples using atomic absorption spectrometry. The cases and controls were similar in age, body mass index, and smoking habits. The median blood level of Cd was 0.32 mu g/l (interquartile range [IQR] 0.00-0.71) in the women with ectopic pregnancies and 0.34 mu g/l (IQR 0.09-0.59) in the controls. There was no significant association between blood cadmium levels and ectopic pregnancy.
Cinsel Yolla Bulaşan Çeşitli Patojenlerin İnfertil Çiftlerdeki Prevalansı ve İn Vitro Fertilizasyon Başarısı Üzerine Etkisi
(2019) Gürsoy, Nafia Canan; Tuncay, Görkem; Karaer, Abdullah; Tecellioğlu, Ayşe Nihan; Yiğit, Hande; Yakupoğulları, Yusuf; Otlu, Barış
Öz: Giriş: Cinsel yolla bulaşan infeksiyonlar kadın ve erkek genital sisteminde oluşturduğu doku hasarı ve fonksiyon kayıpları ile infertilite, ektopik gebelik ve abortus gibi sorunlara neden olabilmektedir. İnfertilite etyopatogenezinde bakteriyel ajanların rolü iyi bilinmesine karşılık, cinsel ilişki ile bulaşabilen bazı viral etkenlerin infertilite ile olan ilişkileri göreceli olarak daha az bilinmektedir. Bu çalışmada in vitro fertilizasyon (IVF) programına alınan infertil hastalarda sitomegalovirüs (CMV), insan papillomavirüs (HPV), herpes simpleks virüs (HSV 1 ve HSV 2), insan immünyetmezlik virüsü (HIV), hepatit B virüsü (HBV), hepatit C virüsü (HCV) ve Chlamydia trachomatis sıklığının araştırılması amaçlanmıştır. Materyal ve Metod: Yaklaşık bir yıllık sürede 149 infertil çiftten semen ve servikal örnekler alındı ve polimeraz zincir reaksiyonu (PCR) yöntemiyle etkenlerin varlığı araştırıldı. Bu etkenlerin IVF tedavi başarısı üzerine etkisi değerlendirildi. Bulgular: Toplam 149 IVF tedavisine alınan infertil çiftin %8.1 (12/149)’inin CMV ile infekte olduğu görülmüş, sperm örneklerinde %2 (3/149), servikal örneklerde ise %6 (9/149) oranında CMV-DNA pozitifliği saptanmıştır. Çiftlerin her ikisinde birlikte CMV infeksiyonuna rastlanmamıştır. Çiftlerin %9.4 (14/149)’ünde HPV infeksiyonu olduğu görülmüş ve bunların sperm örneklerinde %5.4 (8/149), servikal örneklerde ise %7.4 (11/149) oranında HPV-DNA varlığı gösterilmiştir. Sperm örneklerindeki onkojenik yüksek riskli HPV (HR HPV) genotip oranı %37.5 (3/8), en sık saptanan genotipler sırayla HPV 18, 35 ve 39 iken, servikal örneklerdeki HR HPV genotip oranı %63.6 (7/11), en sık saptanan genotipler ise HPV 35, 16, 18, 45 ve 53 olarak bulunmuştur. Çiftlerin her ikisinde birden %3.4 (5/149) oranında HPV-DNA pozitifliği bulunurken, HPV genotipleri için çiftler arası uyum %40 (2/5) olarak saptanmıştır. HPV veya CMV pozitifliğinin erkeklerde sperm parametreleri, IVF tedavisi ile elde edilen oosit, embriyo sayısı ve gebelik ve canlı doğum parametreleri üzerinde istatistiksel olarak anlamlı bir etkisi olmadığı görülmüştür. Çiftlere ait sperm ve servikal örneklerin hiçbirinde C. trachomatis, HSV-1/2, HBV, HCV ve HIV tespit edilmemiştir. Sonuç: İnfertil hastalarda olası etkenlerin araştırıldığı daha kapsamlı çalışmalara gereksinim vardır. Bu konudaki epidemiyolojik veri eksiğinin giderilmesi için de öncelikle IVF kliniklerine başvuran hastalar gibi ulaşılması daha kolay hasta gruplarına ve özellikle ülkemizde endemik olarak görülen bakteriyel/viral etkenlere öncelik tanınması yararlı olacaktır.
Clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome
(2020) Arda Duz, Senem; Tuncay, Gorkem; Karaer, Abdullah
Aim: The goal of this study is to identify clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome. Material and Methods: One hundred seventy eight cases, between the ages 18-30, diagnosed with PCOS, up to Rotterdam criteria, in our clinic between February 2015 -November 2018 were recruited in this cross sectional study. Results: The number was declined 89 by using National Institutes of Health criteria, 132 up to Androgen Excess and PCOS Society criteria. 34.83% of the patients were phenotype A, 15.16% were phenotype B, 24.15% were phenotype C and 25.84% were phenotype D. When we compared the different phenotypes with each other, body mass index, fasting glucose, postprandial glucose, fasting insulin and homeostatic model assessment for insulin resistance were found to be higher in phenotype A. In addition, luteinizing hormone and luteinizing hormone to follicle stimulating hormone ratio was higher in phenotype D than in B and C. When multivariate analysis was performed, body mass index was found to be as a single statistically significant predictive factor on IR. Conclusion: Body mass index was the most effective factor on insulin resistance and the mean body mass index was significantly higher in phenotype A.
Clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome
(2020) Düz, Senem Arda; Tuncay, Görkem; Karaer, Abdullah
Abstract: Aim: The goal of this study is to identify clinical and hormonal characteristics of women with various phenotypes of polycystic ovary syndrome. Material and Methods: One hundred seventy eight cases, between the ages 18-30, diagnosed with PCOS, up to Rotterdam criteria, in our clinic between February 2015 -November 2018 were recruited in this cross sectional study. Results: The number was declined 89 by using National Institutes of Health criteria, 132 up to Androgen Excess and PCOS Society criteria. 34.83% of the patients were phenotype A, 15.16% were phenotype B, 24.15% were phenotype C and 25.84% were phenotype D. When we compared the different phenotypes with each other, body mass index, fasting glucose, postprandial glucose, fasting insulin and homeostatic model assessment for insulin resistance were found to be higher in phenotype A. In addition, luteinizing hormone and luteinizing hormone to follicle stimulating hormone ratio was higher in phenotype D than in B and C. When multivariate analysis was performed, body mass index was found to be as a single statistically significant predictive factor on IR. Conclusion: Body mass index was the most effective factor on insulin resistance and the mean body mass index was significantly higher in phenotype A.
A comparative study on oxidative and antioxidative markers of serum and follicular fluid in GnRH agonist and antagonist cycles
(Springer/Plenum Publishers, 2012) Celik, Ebru; Celik, Onder; Kumbak, Banu; Yilmaz, Ercan; Turkcuoglu, Ilgin; Simsek, Yavuz; Karaer, Abdullah
To determine whether concentrations of oxidative stress markers of follicular fluid and serum are different in GnRH agonist protocol from GnRH antagonist protocol. This was a cross-sectional study. Eighty-four women undergoing controlled ovarian stimulation with either GnRH agonist (n = 39) or GnRH antagonist protocols (n = 45) for IVF/ICSI treatment were assigned by a physician. Blood was obtained at the time of oocyte retrieval, and follicular fluid (FF) from the mature follicles of each ovary was centrifuged and frozen until analysis. Malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), hydroxyl proline (OH-P), sodium oxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) and xanthine oxidase (XO) were assessed in the serum and follicular fluid of each participants. The mean serum concentrations of GSH-Px, GSH and MDA were lower in the GnRH antagonist group compared to GnRH agonist group, but mean serum SOD was higher in the GnRH antagonist group. The mean follicular SOD, ADA and NO were higher in GnRH antagonist group than GnRH agonist group. The IVF/ICSI outcomes were similar in both groups. GnRH antagonist protocol is associated with increased oxidative stress. The relation of GnRH analogues with oxidative stress and its implication in follicular growth needs to be addressed in further studies.
Comparison of the administration of dual and standard trigger in patients undergoing IVF Treatment
(2021) Yigit, Fatih; Karaer, Abdullah; Tuncay, Gorkem
Aim: This study aimed to compare in vitro fertilization (IVF) outcomes in patients who were administered dual trigger due to OHSS risk in the GnRH antagonist protocol with patients who were administered standard trigger.Materials and Methods: The medical files were retrospectively scanned for all the patients who were admitted to Inonu Unıversity department of obstetrics and gynecology.While the dual trigger group was composed of patients with OHSS risk who were stimulated with GnRH antagonist and received dual trigger(hCG + GnRHa) for final oocyte maturation, the age-matched (20-40) control group consisted of patients who were administered standard trigger (10000 IU uhCG or 500 μgrrhCG and obtained oocyte counts of 500 μgr recombinant hCG). Thetwo groups were compared in terms of the oocyte count, MII oocyte count, and pregnancy and birth outcomes.Results: There was no statistically significant difference between the two groups in terms of age, weight, height, BMI, duration of marriage, presence of previous pregnancy, number of previous parities, number of pre-existing children, number of previous abortus stories, number of smokers, duration of infertility, LH, E2, prolactin, TSH levels, infertility causes, and hCG dose endometrium thickness. The number of oocytes and MII oocytes obtained was significantly higher in the dual trigger group compared to the control group. There was no statistically significant difference between the two groups in terms of the number of pregnancies and number of deliveries. Conclusion: Although the number of oocytes and MII oocytes was higher in the dual trigger group compared to the control group, there was no significant difference in terms of the pregnancy ratios and the number of deliveries.
Comparison of the administration of dual and standard trigger in patients undergoing IVF Treatment
(2021) Yigit, Fatih; Karaer, Abdullah; Tuncay, Görkem
Abstract: Aim: This study aimed to compare in vitro fertilization (IVF) outcomes in patients who were administered dual trigger due to OHSS risk in the GnRH antagonist protocol with patients who were administered standard trigger.Materials and Methods: The medical files were retrospectively scanned for all the patients who were admitted to Inonu Unıversity department of obstetrics and gynecology.While the dual trigger group was composed of patients with OHSS risk who were stimulated with GnRH antagonist and received dual trigger(hCG + GnRHa) for final oocyte maturation, the age-matched (20-40) control group consisted of patients who were administered standard trigger (10000 IU uhCG or 500 ?grrhCG and obtained oocyte counts of 500 ?gr recombinant hCG). Thetwo groups were compared in terms of the oocyte count, MII oocyte count, and pregnancy and birth outcomes.Results: There was no statistically significant difference between the two groups in terms of age, weight, height, BMI, duration of marriage, presence of previous pregnancy, number of previous parities, number of pre-existing children, number of previous abortus stories, number of smokers, duration of infertility, LH, E2, prolactin, TSH levels, infertility causes, and hCG dose endometrium thickness. The number of oocytes and MII oocytes obtained was significantly higher in the dual trigger group compared to the control group. There was no statistically significant difference between the two groups in terms of the number of pregnancies and number of deliveries. Conclusion: Although the number of oocytes and MII oocytes was higher in the dual trigger group compared to the control group, there was no significant difference in terms of the pregnancy ratios and the number of deliveries.
Composition and antimicrobial activity of the essential oil from mentha spicata L subsp spicata
(Journal of Essential Oil Research, 2011) Karaer, Abdullah; Toprak, S. Yağmur; Otlu, Barış; Durmaz, Rıza
The air-dried aerial parts of M.spicata L. subsp. spicata, which were collected from eastern Turkey, were subjected to hydrodistillation and the essential oil was obtained in a yield of 3.24% (v/w). The oil was analyzed by GC and GC/ MS. Thirty-seven constituents, accounting for more than 95.3% of the total oil composition, were identified. The main compounds of the essential oil were carvone (48.4%), 1,8-cineole (21.3%), b-pinene (3.5%), b-caryophyllene (3.3%) and trans-dihydrocarvone (2.9%). The antimicrobial activity of the oil was studied. It was evaluated against six microorganisms using the disc diffusion and broth microdilution methods. The oil showed great potential for its antimicrobial activities against Escherichia coli, Candida albicans, Candida tropicalis and moderate activities against Staphylococcus aureus.
Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus
(Springer, 2012) Aslan, Mehmet; Celik, Onder; Celik, Nilufer; Turkcuoglu, Ilgin; Yilmaz, Ercan; Karaer, Abdullah; Simsek, Yavuz
To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 +/- A 8.3 vs. 9.6 +/- A 5.9 ng/ml, P = 0.001) and nesfatin-1 levels were found lower (5.5 +/- A 8.1 vs. 8.1 +/- A 23.9 ng/ml, P = 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 +/- A 4.3 and 8.2 +/- A 1.9 ng/ml, P = 0.618) and nesfatin-1 levels (5.4 +/- A 4.0 and 6.2 +/- A 10.3 ng/ml, P = 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.
The Definition of the Upper Limit of Adolescent Age in Terms of Adverse Pregnancy Outcomes
(Springernature, 2021) Duz, Senem Arda; Tuncay, Gorkem; Cengiz, Murat; Karaer, Abdullah
Introduction This study aims to reveal the maternal and neonatal adverse outcomes, associated with adolescent pregnancies in our country, to investigate whether the 20 to 21-year-age group, which is very close to the adolescent age, is similar to the adolescent age group in terms of adverse outcomes, and so to contribute to the definition of the upper limit in adolescent age for pregnancy. Methods Four hundred and twenty-four pregnant women under the 20-year-age, 450 pregnant women at 20 to 21year-age, and 450 pregnant women between 22 and 25-year-age were included in this retrospective study. Maternal demographic features, clinical characteristics, obstetric complications, maternal outcomes, neonatal complications, and neonatal outcomes were collected from the medical records of the participants. Results There were statistically significant differences between under 20-year-age and 22 to 25-year-age, regarding gestational age at birth, maternal duration of hospitalization after delivery, mode of delivery, preterm delivery rate, very low birth weight, and low birth weight, first minute Apgar score, the presence of transient tachypnea of the newborn. Conclusion The upper age limit for the adolescent age, which is considered risky in terms of maternal and neonatal adverse outcomes, was found to be compatible with the upper age limit, which is 19 years, defined by World Health Organization.
ECTOPIC PELVIC KIDNEY MIMICKING ADNEXAL MASS
(Galenos Yayincilik, 2012) Yilmaz, Ercan; Simsek, Yavuz; Karaer, Abdullah; Celik, Ebru; Turkcuoglu, Ilgin; Dogan, Cagdas; Aydin, Engin
Ectopic kidney, common developmental disorder in women with abnormalities of the genitourinary system and in clinic, mimicking adnexal pathologies. In this case report, hydronephrosis developed a pelvic ectopic kidney mimicking adnexal cystic pathology.
The effect of seminal plasma cadmium and lead levels on semen parameters in male subjects of infertile couples: a prospective cohort study
(Taylor & Francis Inc, 2021) Tuncay, Gorkem; Karaer, Abdullah; Tanrikut, Emrullah; Ozgul, Onur
The aim of this prospective study was to investigate whether there is a relationship between seminal plasma cadmium (Cd) and lead (Pb) levels and semen parameters in male partners of infertile couples. Two hundred fifty one (251) men recruited with no history of occupational exposure to toxic metals. After semen analysis, seminal Cd and Pb levels were measured using atomic absorption spectrometry. Cadmium levels in men with hypospermia was significantly higher than men with normal semen volume (p = .049). In contrast, there was no statistically significant difference in median seminal Pb levels between men with hypospermia and men with normal semen volume (p = .13). There was no statistically significant association between seminal plasma Cd and Pb levels sperm concentration, motility, morphology and total progressively motile sperm count. These findings suggest that environmental Cd exposure may contribute to low semen volume in male partners of infertile couples. IMPACT STATEMENT What is already known on this subject? Toxic metals may adversely affect both male and female reproductive system. What the results of this study add? Seminal plasma cadmium levels in men with hypospermia were statistically significantly higher than men with normal semen volume. What the implications are of these findings for clinical practice and/or further research? Patients should be informed about possible adverse effects of toxic metals.

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