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  • Küçük Resim
    Öğe
    The effect of transcatheter aortic valve implantation on ventricular repolarization indices and neutrophil-to-lymphocyte ratio
    (2020) Kaya, Hakan
    Aim: The electrocardiographic QT dispersion (QTd), Tpe/QT ratio and Tpeak-Tend (Tpe) interval have been known as ventricular repolarization indices. Neutrophil–to- lymphocyte ratio (NLR) is an inflammatory marker that is newly described. Increased QTd, Tpe/QT ratio, inflammation and Tpe interval are associated with ventricular arrhythmia (VA). In patients with severe aortic stenosis (AS), VA has a key role in terms of morbidity and mortality. The present study aimed at examining whether transcatheter aortic valve implantation (TAVI) affects ventricular repolarization indices and NLR. Material and Methods: Study population consisted of a total of 44 patients undergoing TAVI. Echocardiographic and laboratory parameters of patients were evaluated before TAVI and sixth month after TAVI. Comparioson of electrocardiographic QTd, Tpe/QT ratio, Tpe interval and NLR of the same petients were made before TAVI and sixth month after TAVI.Results: QT interval, corrected QT interval and heart rate were similar before and after TAVI (p>0.05 for all). There was a statistically significant decrease in QTd (26.0±9.1 vs. 21.3±7.2 ms; p=0.008), Tpe interval (88.43±12.6vs. 78.8±10.1 ms; p0.001), NLR (3.08±2.0 vs. 2.16±0.73; p=0.001) and Tpe/QT ratio ( 0.23±0.3 vs. 0.21±0.1; p=0.024) after TAVI. Morever, the reduction in the Tpe interval and Tpe / QT ratio after TAVI was found to be significantly correlated with NLR (r=0.400, p=0.007; r=0.396, p=0.008; respectively).Conclusion: TAVI does not only reduce symptoms in patients with severe AS, but may also be effective in reducing risk of VA by improving factors affecting ventricular repolarization.
  • Küçük Resim Yok
    Öğe
    Evaluation of frontal QRS-T angle values in electrocardiography in patients with chronic rhinosinusitis
    (Bmc, 2023) Abus, Sabri; Koparal, Mehtap; Kaya, Hakan; Kapici, Olga Bayar; Tasolar, Mehmet Hakan; Tibilli, Hakan
    BackgroundChronic Rhinosinusitis (CRS) refers to inflammation of the paranasal sinuses and nasal mucosa. Electrocardiographic indicators of ventricular repolarization have been shown to correlate with systemic inflammation parameters. Recently, the frontal QRS-T (fQRS-T) angle has been accepted as a new indicator of ventricular depolarization and repolarization heterogeneity. The (fQRS-T) angle is recommended in predicting the risk of malignant ventricular arrhythmia. In this study, we aimed to evaluate the ventricular arrhythmia potential in patients with chronic rhinosinusitis by examining the relationship between fQRS-T angle on ECG and inflammation markers.MethodsInflammatory markers as well as electrocardiographc (ECG) f(QRS-T) angle, QRS duration, QT interval and corrected QT interval were examined in 54 patients with CRS versus 56 healthy control subjects.ResultsThe f(QRS-T) angle was significantly higher in CRS patients than in healthy controls (p < .001). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) were significantly higher in CRS patients compared to healthy controls (p < .001, for all). Based on correlation analysis, NLR and f(QRS-T) angles were highly correlated (r = .845, p < .001), and according to the results of linear regression analysis, NLR was independently associated with the f(QRS-T) angle (t = 5.149, Beta = 0.595, p = < 0.001).ConclusionBoth f(QRS-T) angle and NLR are significantly increased in CRS patients compared to healthy controls, with increases in NLR also independently associating with increases in f(QRS-T) angle. While the increases in f(QRS-T) angle did not result in clinically alarming absolute values for f(QRS-T), CRS patients might nonetheless be at relatively higher risk for malignant cardiac arrhythmias.