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Öğe The Effect of Beta Glucan on Cisplatin Ototoxicity(Springer India, 2014) Bayindir, Tuba; Iraz, Mustafa; Kelles, Mehmet; Kaya, Serdar; Tan, Mehmet; Filiz, Aliye; Toplu, YukselThis study was undertaken to investigate the effect of betaglucan in ameliorating cisplatin ototoxicity. Rats were divided into four groups: cisplatin (C), cisplatin plus beta glucan (CB), beta glucan (B), and control (K). Distortion product otoacoustic emissions were elicited in 0th, 1st, and 5th days. For the group C differences were observed at 8,003 and 9,515 Hz between 0th and 5th days' measurements. In the group CB there were differences at frequencies of 3,996, 4,757, 5,660, and 6,726 Hz between 0th and 5th days' measurements. For the group B there were significant recovery in some frequencies. The observation of significant deterioration in terms of hearing in the group treated with cisplatin plus betaglucan may be suggested that depended on the increase of permeability and tissue conductance into the inner ear which may be caused by betaglucan. Further long-term follow-up studies by using different doses may clarify this matter.Öğe The Effects of a New Hemostatic Agent on Hearing in Rats(Aves, 2010) Kalcioglu, M. Tayyar; Bayindir, Tuba; Iraz, Mustafa; Kaya, Serdar; Can, SermetObjective: Ankaferd Blood Stopper (ABS), a standardized mixture of five plants, has been used as a hemostatic agent. Studies have shown the hemostatic effectivity of this agent that suggests a potential usage in otological surgeries. However,side effects on hearing of this agent are unknown. In this study, hearing affection of local and systemic usage of ABS was investigated by using distortion product otoacoustic emissions (DPOAEs). Materials and Methods: Thirty-two male Wistar rats were used. The animals were divided into four groups. Baseline DPOAE measurements were performed. Subsequently, intratympanic ABS administration to the firstgroup and intratympanic saline administration to the second group were performed. Intraperitoneal ABS was injected to the third group. The fourth group was not administered any intervention. Side effects of ABS on hearing were evaluated by repeated DPOAE measurements carried out before and at 1st, 7th, and 40th days following the applications. Results: On days 7 and 40; measurement parameters of DPgrams of intratympanic ABS group were found to have significantly deteriorated in some frequencies (p(0.05). The measurements of the other groups revealed no significant differences (p>0.05). Hearing loss was not observed in systemic absorption group but, determined in intratympanic application group. Conclusion: Our findings may suggest that hearing loss may be either due to ototoxic side effect of ABS, prolonged mass effect of it, or because of inflammation. Further studies with longer follow up period and histopathological examinations are needed to answer these existing questions.Öğe Efüzyonlu otitis media ile pediatrik obezite ilişkisinin araştırılması(İnönü Üniversitesi, 2011) Kaya, SerdarPediatrik obezitenin, efüzyonlu otitis media gelişimi üzerine etkisinin olup olmadığının araştırılması amaçlanmıştır. Materyal ve Metod: Çalışmaya 2-10 yaş arası çocuklar alındı. Çalışma grubuna 60 efüzyonlu otitis medialı çocuk, kontrol grubuna ise 86 sağlam çocuk mevcuttu. EOM tanısı anamnez, otoskopi, timpanometri ve yaşı uygun olanlara saf ses odyometrisi yapılarak kondu. Çalışma grubundaki tüm çocukların adenoid vejetasyon oranları ve tonsil hipertrofisi olup olmadığı not edildi. Kontrol grubuna ise sistemik ve KBB hastalığı olmayan çocuklar alındı. Çalışma ve kontrol grubundaki toplam 146 çocuğun boy ve ağırlık ölçümleri yapıldı. Her çocuğun VKİ, RA ve Z skor değerleri hesaplandı. Yaşa ve cinsiyete uygun persentil eğrileri kullanılarak düşük kilolu, normal kilolu, aşırı kilolu ve obez olmak üzere 4 gruba ayrıldı. İstatistiksel değerlendirmede SPSS for Windows Version 13 programı kullanıldı. P<0,05 olanlar istatistiksel olarak anlamlı kabul edildi. Bulgular: Çalışma ve kontrol grubu VKİ, RA, Z skoru ortalamaları yönünden karşılaştırıldığında VKİ ve RA ortalamalarının çalışma grubunda istatistiksel olarak anlamlı olacak şekilde yüksekti (VKİ için p=0,035 ve RA için p=0,026). Her iki grup arasında VKİ ve RA kullanılarak belirlenen düşük kilolu, normal kilolu, aşırı kilolu ve obez çocukların istatistiksel karşılaştırılmasında sadece RA kullanılan grupta istatistiksel olarak fark olduğu görüldü (p=0,012). VKİ'ye göre çalışma ve kontrol grubunda obez+aşırı kilolular bir grup kabul edildiğinde, obez+aşırı kilolular, normal ve düşük kilolu çocuklar arasında istatistiksel olarak anlamlı fark vardı (p=0,044). RA'ya göre yapılan değerlerdirmede obez+aşırı kilolular bir grup kabul edildiğinde, obez+aşırı kilolular, normal ve düşük kilolu kişiler arasında istatistiksel olarak anlamlı fark vardı (p=0,005). Ayrıca Z skoru ortalamaları arasında istatistiksel olarak anlamlı fark olmamasına rağmen çalışma grubunda ortalama değer kontrol grubuna göre daha yüksekti. Çalışma ve kontrol grupları ayrı ayrı okul öncesi (2-6 yaş) ve okul dönemi(6-10 yaş) olarak ikiye ayrıldı. 6-10 yaş grubunda RA ortalamaları çalışma grubunda istatistiksel olarak anlamlı olacak şekilde yüksekti (p=0,023). Çalışma grubundaki unilateral EOM'li çocukların, bilateral EOM'li çocukların ve kontrol grubundaki çocukların VKİ, RA ve Z skoru ortalamaları karşılaştırıldığında RA ortalamaları yönünden anlamlı fark vardı (p=0,035). Çalışma grubundaki her iki kulağında EOM olan 31 hastanın RA ortalaması kontrol grubundaki çocukların RA ortalamasından istatistiksel olarak anlamlı yüksek bulundu (p=0,046). Çalışma grubundaki çocukların 36(%60)'sında %50'nin altında adenoid vejetasyon bulunurken 24(%40) çocukta %50'nin üstünde adenoid vejetasyon bulundu. Sonuç: Çocuklarda obezite 6-10 yaş grubunda daha belirgin olmak üzere EOM etyolojisinde rol oynayabilir.Öğe Evaluation of the Protective Effect of Beta Glucan on Amikacin Ototoxicity Using Distortion Product Otoacoustic Emission Measurements in Rats(Korean Soc Otorhinolaryngol, 2013) Bayindir, Tuba; Filiz, Aliye; Iraz, Mustafa; Kaya, Serdar; Tan, Mehmet; Kalcioglu, Mahmut TayyarObjectives. This experimental study investigated the possible protective effect of beta glucans on amikacin ototoxicity. Methods. Thirty-eight rats with normal distortion product otoacoustic emissions (DPOAEs) were divided into four groups. Group K was the control group. Group A was injected intramuscularly (i.m.) with amikacin 600 mg/kg/day between days 1-15. Group AB was given beta glucan gavage 1 mg/kg/day on days 0-15 and given amikacin 600 mg/kg/day i.m. on days 1-15. Group B was administered only beta glucan gavage, 1 mg/kg/day, on days 0-15.The DPOAEs were elicited in different frequency regions between 2,003 and 9,515 Hz, as distortion product diagrams (DPgrams), before and after the medication was administered, in all groups, on days 1, 5, 10, and 15. Results. No significant changes in the DPgrams were observed in group K. In group A, significant deterioration was observed at the 8,003 and 9,515 Hz frequencies on day 10, and at the 3,991, 4,557, 5,660, 6,726, 8,003, and 9,515 Hz frequencies on day 15. For group AB, statistically significant deterioration was observed at the 2,824, 8,003, and 9,515 Hz frequencies on day 15. The results for group B showed a significant improvement of hearing at the 2,378, 2,824, 3,363, and 3,991 Hz frequencies on day 1, at the 3,363, 3,991, and 8,003 Hz frequencies on day 10, and at the 8,003 Hz frequency on day 15. Conclusion. This study suggests that amikacin-induced hearing loss in rats may be limited to some extent by concomitant use of beta glucan.Öğe Is there any relationship between benign endometrial pathologies and metabolic status?(Taylor & Francis Inc, 2019) Kaya, Serdar; Kaya, Basak; Keskin, Hueseyin Levent; Tetik, Burcu Kayhan; Yavuz, Filiz AyseThe aim of this study was to assess the relation between benign endometrial pathologies (polyp and/or hyperplasia without atypia) and the metabolic status (insulin resistance and metabolic syndrome) of the patients. A total of 168 cases were enrolled in the study. The patients were classified according to the presence of benign endometrial pathologies and their menopausal status. Then, the subjects were evaluated according to the metabolic syndrome criteria and the presence of an insulin resistance. The insulin resistance levels of the cases were analysed by four different methods. Obesity and a waist circumference of greater than 88 cm were observed significantly more in the study group with endometrial pathologies (p = .005 and p < .001, respectively). It was also observed that a fasting blood glucose level of higher than 110 mg/dL increased the risk of developing endometrial polyps and/or hyperplasia without atypia by almost five folds (OR: 5.26, 95% CI: 1.25-22.12). Furthermore, an insulin resistance was found to be significantly high in the study group (p = .002). Based on the observed significant relationship between an insulin resistance and benign endometrial pathologies, it can be concluded that insulin resistance plays an important role in the development of benign endometrial pathologies.
