The Effects of a New Hemostatic Agent on Hearing in Rats
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Ankaferd Blood Stopper (ABS), a standardized mixture of five plants, has been used as a hemostatic agent. Studies have shown the hemostatic effectivity of this agent that suggests a potential usage in otological surgeries. However,side effects on hearing of this agent are unknown. In this study, hearing affection of local and systemic usage of ABS was investigated by using distortion product otoacoustic emissions (DPOAEs). Materials and Methods: Thirty-two male Wistar rats were used. The animals were divided into four groups. Baseline DPOAE measurements were performed. Subsequently, intratympanic ABS administration to the firstgroup and intratympanic saline administration to the second group were performed. Intraperitoneal ABS was injected to the third group. The fourth group was not administered any intervention. Side effects of ABS on hearing were evaluated by repeated DPOAE measurements carried out before and at 1st, 7th, and 40th days following the applications. Results: On days 7 and 40; measurement parameters of DPgrams of intratympanic ABS group were found to have significantly deteriorated in some frequencies (p(0.05). The measurements of the other groups revealed no significant differences (p>0.05). Hearing loss was not observed in systemic absorption group but, determined in intratympanic application group. Conclusion: Our findings may suggest that hearing loss may be either due to ototoxic side effect of ABS, prolonged mass effect of it, or because of inflammation. Further studies with longer follow up period and histopathological examinations are needed to answer these existing questions.
Açıklama
31st Turkish National Congress of Otorhinolaryngology Head and Neck Surgery -- SEP 28-OCT 01, 2009 -- Antalya, TURKEY
Anahtar Kelimeler
Ankaferd Blood Stopper, Secondary, Efficacy
Kaynak
Journal of International Advanced Otology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
6
Sayı
2
