The Effects of a New Hemostatic Agent on Hearing in Rats

Basit Öğe Kaydı
dc.authoridBayindir, Tuba/0000-0003-4150-5016;
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidBayindir, Tuba/ABG-9517-2020
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.contributor.authorKalcioglu, M. Tayyar
dc.contributor.authorBayindir, Tuba
dc.contributor.authorIraz, Mustafa
dc.contributor.authorKaya, Serdar
dc.contributor.authorCan, Sermet
dc.date.accessioned2024-08-04T20:32:27Z
dc.date.available2024-08-04T20:32:27Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description31st Turkish National Congress of Otorhinolaryngology Head and Neck Surgery -- SEP 28-OCT 01, 2009 -- Antalya, TURKEYen_US
dc.description.abstractObjective: Ankaferd Blood Stopper (ABS), a standardized mixture of five plants, has been used as a hemostatic agent. Studies have shown the hemostatic effectivity of this agent that suggests a potential usage in otological surgeries. However,side effects on hearing of this agent are unknown. In this study, hearing affection of local and systemic usage of ABS was investigated by using distortion product otoacoustic emissions (DPOAEs). Materials and Methods: Thirty-two male Wistar rats were used. The animals were divided into four groups. Baseline DPOAE measurements were performed. Subsequently, intratympanic ABS administration to the firstgroup and intratympanic saline administration to the second group were performed. Intraperitoneal ABS was injected to the third group. The fourth group was not administered any intervention. Side effects of ABS on hearing were evaluated by repeated DPOAE measurements carried out before and at 1st, 7th, and 40th days following the applications. Results: On days 7 and 40; measurement parameters of DPgrams of intratympanic ABS group were found to have significantly deteriorated in some frequencies (p(0.05). The measurements of the other groups revealed no significant differences (p>0.05). Hearing loss was not observed in systemic absorption group but, determined in intratympanic application group. Conclusion: Our findings may suggest that hearing loss may be either due to ototoxic side effect of ABS, prolonged mass effect of it, or because of inflammation. Further studies with longer follow up period and histopathological examinations are needed to answer these existing questions.en_US
dc.identifier.endpage159en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77954892602en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://hdl.handle.net/11616/95089
dc.identifier.volume6en_US
dc.identifier.wosWOS:000279459900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of International Advanced Otologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectSecondaryen_US
dc.subjectEfficacyen_US
dc.titleThe Effects of a New Hemostatic Agent on Hearing in Ratsen_US
dc.typeConference Objecten_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu