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Öğe excretion rate and composition of skin surface lipids on the foreheads of adult males with type iv hyperlipoproteinemia(2007) Güldür T.; Bayraktar N.; Koçer M.; Kaynar O.; Beker G.; Özcan H.Objectives: Most of the lipids of the skin surface come from sebaceous glands secretions, called sebum. Some of the sebum lipids are synthesized by sebaceous cells while some are reportedly derived from the plasma. Role of blood lipoproteins in sebum secretion rate and composition is unclear. To this end, excretion rate and composition of skin surface lipids of normo- and type IV hyperlipoproteinemic subjects were compared. Design and Methods: Quantitative analysis of skin surface lipids was performed by three successive sampling on left, middle, and right zones of the forehead with a sebumeter. Skin surface lipid samples for the compositional analysis were collected from the forehead, extracted into n-hexane, and analyzed by high performance thin layer chromatography (HPTLC). HPTLC plates were scanned with a densitometer for the quantification of the lipids. Results: Skin surface lipids from type IV hyperlipoproteinemic subjects contained higher proportion of wax. © 2007, by Walter de Gruyter GmbH & Co. All rights reserved.Öğe The humoral immun response of mice to liposomes containing Brucella melitensis outer membrane fragments(2008) Onurdag F.K.; Degim T.; De?im Z.; Kutlu I.; Kaynar O.; Gunes G.; Abbasoglu U.Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes Brucella melitensis REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the Brucella outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the Brucella outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated B. melitensis REV-1 vaccine in mice. © Medwell Journals, 2008.