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Öğe Berberine(Elsevier, 2020) Keskin M.; Kaya G.; Guragac Dereli F.T.; Belwal T.Alzheimer’s is a disease related to the nervous system known to produce nonreversible degeneration of cognitive functions. It is currently among the leading causes of death for people 65 and older. However, no effective treatment strategy has been found to overcome Alzheimer’s disease (AD). Various scientific research studies have revealed that berberine has a significant role in the prevention and management of AD by exhibiting neuroprotective activity via antioxidant, antiapoptotic, antiinflammatory, anticholinesterase, and antiamyloidogenic effects. © 2021 Elsevier Inc. All rights reserved.Öğe Comparison of biochemical, antimicrobial and cytotoxic activities of different propolis samples from Malatya and Bilecik(Syscom 18 SRL, 2020) Keskin M.; Karlidag S.; Yilmaz O.; Tatlici E.; Karabulut E.; Apohan E.; Yesilada O.Propolis is a resinous natural mixtures collected and produced by honey bees. It is rich in essential oils and phenolic components so it has high levels of antioxidant, antimicrobial, anti-inflammatory and anti-tumoral activity. In this study the biochemical activity of propolis extracts were determined. The antimicrobial activity and cytotoxic activity of the extracts of the nine different propolis samples were invastigated. Their antimicrobial activities were tested by microdillution metod and define as minimum inhibitory concentration (MIC). Chemical composition of extracts was determined by using GC-MS equipment. Total phenolic content and antioxidant activity of the extracts was measured. Antimicrobial and cytotoxic activity of the extracts was carried out as well. All of the extracts showed antimicrobial activity on bacteria and yeasts used. Extracts had generally lower MIC values on yeasts. Therefore, yeasts were detected as more susceptible against the propolis extracts than the bacteria. Cytotoxic activity of extract were determined aganist A549 and Beas2B cell lines and IC50 values were calculated. Ma-Arapgir had the highest cytotoxic activity on A549 and Beas2B. They were determined as 6.72 and 26.44 mg/mL, respectively. It could be concluded that propolis extracts have antimicrobial and cytotoxic activity thus, propolis could be used in the treatment of cancer. © 2020 SYSCOM 18 S.R.L.. All rights reserved.Öğe Green approaches for synthesis of nanophytopharmaceuticals/nanophytodelivery systems(Wiley Blackwell, 2022) Kaya G.; Keskin M.; Rudrapal M.Plants rich in phytochemicals are used in the preparation of nanoparticles due to their strong antioxidant properties. Recently, nanophytopharmaceuticals are widely used in various drug delivery systems. It has wide acceptability due to its increasingly tested therapeutic values and minimal side effects. With the developments in biotechnology, genetics and combinatorial chemistry technologies, new, more powerful, and specific drug delivery systems have been designed in the last decade. Restrictions associated with traditional phytopharmaceuticals have been improved by designing and using "nanodelivery systems" (NDS). The most important feature of NDS is continuous drug release, target organ orientation, and improved patient compliance. Nanophytopharmaceuticals can be used to target a specific area of the body, which improves its selectivity, solubility, delivery, safety, and efficacy, thus the need for frequent high doses to be administered. They are not metabolized by stomach and liver enzymes and the drug circulates for a longer period of time. It suggests that phytopharmaceuticals with NDS will help in increasing the effectiveness of herbal medicines. © 2022 John Wiley & Sons, Inc. All rights reserved.Öğe Micromeria persica Boiss. (Labiatae): A new record for Turkey(2007) Keskin M.; Sadiko?lu N.Micromeria persica Boiss. (Labiatae), is a new record for the Flora of Turkey in Hatay province. Illustration and description of the new species are given based on mainly examined specimens and compared with allied species.Öğe Nanodelivery of herbal and phyto-antioxidants(Wiley Blackwell, 2022) Kaya G.; Keskin M.; Keskin S.; Rudrapal M.Phyto-bioactive compounds such as curcumin, resveratrol, catechins, and quercetin are among the most widely used natural compounds used as potential modulators of free radical-induced cellular damage. However, the therapeutic potential of these compounds is limited by their low bioavailability associated with poor solubility, stability, and absorbance in the gastrointestinal tract. Recently, new nanotechnology-based systems have been developed for the therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems provide many benefits in preclinical research over conventional preparations, including superior solubility and stability, extended half-life, improved epithelial permeability and bioavailability, increased tissue targeting, and minimized side effects. © 2022 John Wiley & Sons, Inc. All rights reserved.
