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    Effect of streptozotocin on plasma insulin levels of rats and mice: A meta-analysis study
    (2015) Koksal B.
    Background: In the studies focusing on diabetic organisms, Streprozotocine (STZ) is a frequently used agent to induce diabetes in rats and mice. However the current studies do not represent practical importance of their statistical findings. For showing practical importance of the differences in plasma insulin levels of diabetic rats and mice induced by STZ, there should be a statistical synthesis regarding statistical findings of the studies. Aim: The purpose of this study is to make a meta-analysis of the studies on the effect of STZ on plasma insulin levels in diabetic rats and mice. Materials and methods: In this study 39 effect sizes (37 studies) about levels of plasma insulin were analyzed by calculating individual effect sizes (d) and mean effect size. Results: The effect sizes were between -13.7 and +65.3 and the mean effect size value (+9.33) represented a large effect indicating that STZ was an effective agent to significantly decrease plasma insulin levels of diabetic rats and mice. Conclusion: It can be said that the differences in plasma insulin levels between STZ-applied and no application groups has a practical importance in making animal model of diabetes. © 2015, Burcu Koksal.
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    Investigation of propolis effects on learning and memory of diabetic Sprague dawley rats induced by streptozotocin
    (Scibulcom Ltd., 2017) Koksal B.; Emre M.H.
    The purpose of this study is to investigate possible effects of propolis on learning and memory functions of diabetic rats induced by streptozotocin (STZ). In the study, 51 young male adult Sprague Dawley rats were involved and the rats were exposed to eight-arm radial maze applications for evaluation of their learning and memory functions during 4 weeks. In the first three weeks latent learning was observed while short and long term memory functions were observed in the last week. The rats were assigned into four different groups: control (n = 14), only STZ application (n = 12), propolis application before STZ exposure (n = 12) and propolis application after STZ exposure (n = 13). The findings showed that no significant effect of propolis on latent learning, short and long term memory functions of diabetic rats was determined; moreover diabetes did not lead to harms on latent learning, short and long term memory functions. In conclusion, it can be said that the time might not be enough to detect learning and memory dysfunctions caused by diabetes and effects of propolis, however it is seen that propolis is an effective chemical in decreasing blood glucose levels of diabetic rats.