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    Melatonin improves methanol intoxication-induced oxidative liver injury in rats
    (Blackwell Publishing Ltd, 2007) Kurcer Z.; O?uz E.; Iraz M.; Fadillioglu E.; Baba F.; Koksal M.; Olmez E.
    This study was performed to evaluate the effect of melatonin on methanol-induced liver injury. We evaluated the levels of malondialdehyde (MDA), protein carbonylation (PC), myeloperoxidase (MPO) activities and to assess lipid peroxidation, protein oxidation, neutrophil accumulation and nitrite which is a stable end product of nitric oxide respectively. We also studied superoxide dismutase, catalase, and glutathione peroxidase activities of liver tissue to evaluate the changes in the antioxidant status. Histopathological alterations were also determined. The experiment was performed on Wistar rats, which received intragastric 3 g/kg methanol as a 50% solution in isotonic saline once. After 6 and 24 hr all the drug received and intoxicated rats were killed under anesthesia. Pretreatment with melatonin (10 mg/kg) decreased the MDA levels significantly, restored the PC levels to the control, prevented the increase of nitrite level and MPO activity significantly and reversed to the control levels, prevented the reduction in all of the antioxidant enzyme activities. Additionally in melatonin treated group piecemeal necrosis, lobular lytic necrosis, and portal inflammation returned to normal histologic appearances when compared with methanol administration. In conclusion, melatonin has protective effects against methanol-induced hepatic injury. © 2007 The Authors.
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    Robust temperature control of MSF desalination plants with coefficient diagram method
    (2003) Koksal M.; Hamamci S.E.
    Design of a controller sufficiently robust to the parametric uncertainties for the plant parameters is an important problem. Coefficient Diagram Method (CDM) is shown to be an efficient control technique to solve this problem. The controller design by CDM is based on the choice of the coefficients of the characteristic polynomial of the closed loop system according to the convenient performance criteria such as equivalent time constant, and stability indices. In this study, the controllers are designed for three temperature loops of large Multi-stage flash (MSF) desalination system by using CDM; then, obtained time domain characteristics are compared with the results of some other methods. It is shown that CDM design is more stable and robust whilst giving the desired time domain system performance.