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Öğe Adrenomedullin and nitrite levels in children with Bartter syndrome(Springer-Verlag, 2000) Balat, A; Çekmen, M; Yürekli, M; Kutlu, O; Islek, I; Sönmezgöz, E; Çakir, MChildren with Bartter syndrome have lower than normal vascular reactivity with normotension in spite of biochemical and hormonal abnormalities which are typical of hypertension. Nitric oxide (NO) is a potent endogenous vasodilator, and plays an important role in the control of vascular tone. Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from human pheochromocytoma. The possible role of NO and PLM in maintaining this reduced vascular reactivity was examined by studying plasma and urinary nitrite, a stable metabolite of NO, and AM levels in ten children with Bartter syndrome, ten healthy controls, and five children with hypokalemia of causes other than Bartter syndrome (pseudo-Bartter). Urinary excretion of nitrite (mu mol/mg urinary creatinine) was 8.9.+/-1.2 in children with Bartter syndrome, 4.7.+/-0.9 in healthy controls, and 2.9.+/-0.8 in pseudo-Bartter (P<0.05). Plasma nitrite levels (mol/l) were 101.9+/-23.4, 59.9+/-14.7, and 65.0+/-29.7, respectively (P>0.05), in the three groups. Urinary excretion of AM (pmol/mg urinary creatinine) was 187+/-40, 65+/-10, and 160+/-50, respectively (P<0.05), in the three groups. Plasma AM levels were 47.4+/-1.8, 39.9+/-5.9, and 42.4+/-3.9, respectively (P>0.05), in the three groups. The same parameters were repeated in the two groups of controls and in the Bartter patients in the 6th month of therapy. Urinary nitrite and AM levels were still higher in the Bartter patients than in the other groups. We conclude that in Bartter syndrome the increased NO production may be responsible for the reduced vascular response of the disease. Initially, increased levels of AM in Bartter syndrome and pseudo-Bartter may be a compensatory response to acute hypokalemia; however, continuation of a high level of urinary excretion of AM in children with Bartter syndrome may suggest also the possible role of AM in the reduced vascular response of the disease.Öğe Adrenomedullin and nitrite levels in children with minimal change nephrotic syndrome(Springer-Verlag, 2000) Balat, A; Çekmen, M; Yürekli, M; Gülcan, H; Kutlu, O; Türköz, Y; Yologlu, SNitric oxide (NO) serves many functions within the kidney, and recent evidence suggests that NO contributes to glomerular injury. Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from human pheochromocytoma. Recent studies showed that plasma AM concentrations correlated with the extent of proteinuria. We have examined the possible role of these two agents by studying plasma and urinary total nitrite (NO-(2) + NO-(3)) and AM levels in children with minimal change nephrotic syndrome (MCNS). In comparison with healthy controls, children with MCNS had increased urinary nitrite excretion (mu mol/mg urinary creatinine), irrespective of whether the disease was in relapse or remission (3.2+/-0.2 in relapse, n=13; 1.9+/-0.3 in remission, n=12; 1.0+/-0.2 in controls, n=10, P<0.05). Plasma nitrite levels (mol/l) were high in relapse compared with controls (53.2+/-8.7 vs 32+/-4.0, P<0.05). Plasma AM levels (pmol/ml) were decreased in relapse (27.6+/-1.4 in relapse, 43.3+/-1.2 in remission, 41.5+/-1.6 in controls, P<0.05). Urinary AM levels (pmol/mg urinary creatinine) were significantly higher in relapse than in remission and in controls (156+/-43 in relapse, 56+/-18 in remission, 36+/-16 in controls, P<0.05). Our data indicate that NO may play a role in mediating the clinical manifestations of MCNS in children. However, changes in AM levels may be the result of heavy proteinuria.Öğe Ectopic thymic tissue: A cause of emphysema in infants(Elsevier Science Inc, 1999) Baysal, T; Kutlu, R; Kutlu, O; Yakinci, C; Karaman, IEctopic thymic tissue can present a diagnostic dilemma when it is located in the posterior mediastinum. The diagnosis can be made by awareness of it and bq use of computed tomography (CT) and magnetic resonance imaging (MRI). Rarely, ectopic thymus are reported to cause airway obstruction. In infants ectopic thymic tissue should also be considered in the differential diagnosis of secondary pneumonias and emphysema especially located in the upper lung zones. (C) Elsevier Science Inc., 1999.Öğe Effects of Lycium barbarum on bacterial translocation in thioacetamide induced liver injury in rats(European Journal of Inflammation, 2015) Bilgiç, Yılmaz; Harputluoğlu, Murat; Kutlu, O; Demirel, Ulvi; Gül, Mehmet; Otlu, Barış; Temel, İsmail; Gürsoy, S.; Dertli, Ramazan; Selçuk, Engin Burak; Yılmaz, İsmet; Kilis, TubaBackground and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum. Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.Öğe Epidemiologic and clinical clinical features of a sepsis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) in a pediatric intensive care unit(Mosby-Elsevier, 2004) Tekerekoglu, MS; Durmaz, R; Ay, S; Çiçek, A; Kutlu, O[Abstract Not Available]Öğe Head circumference measurement of urban children aged between 6 and 12 in Malatya, Turkey(Elsevier Science Bv, 2001) Karabiber, H; Durmaz, Y; Yakinci, C; Kutlu, O; Gumusalan, Y; Yologlu, S; Yalaz, KHead circumference (HQ is one of the most significant findings in physical examination, especially in the evaluation of the development and early diagnosis of neurological disorders in children. In the standard charts for developmental evaluation of Turkish children, there is no HC reference values for children over 6 years of age. Since the HC standards show differences among races and generations, many researchers have obtained normal values for their own populations, and recommend periodic reevaluation of these standards. In this study, the HC of 1826 healthy children (945 male, 881 female) aged between 6 and 12 years was measured in order to establish the Turkish standards. The sample represented various socioeconomic levels in the city of Malatya, Turkey. The study was conducted in ten schools and measurements were done twice by a pediatrician and the mean was recorded. Charts and graphs for boys and girls were prepared separately. Results were compared to the values of other populations. HC values of Turkish children were similar to that of Irish children. The data obtained in this study may replace the Nelhaus criteria to be used in clinics. However, a more widespread study should be carried out by including children from different regions of Turkey. (C) 2001 Elsevier Science B.V. All rights reserved.Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Prevalence of epilepsy in 3637 children of primary school age in the province of Malatya, Turkey(Oxford Univ Press, 2001) Karabiber, H; Yakinci, C; Durmaz, Y; Kutlu, O; Soylu, H[Abstract Not Available]Öğe Primary intestinal lymphangiectasia(Lippincott Williams & Wilkins, 2001) Uguralp, S; Mutus, M; Kutlu, O; Çetin, S; Baysal, T; Mizrak, B[Abstract Not Available]
