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Öğe In vitro and in vivo acetylcholinesterase-inhibiting effect of new classes of organophosphorus compounds(Wiley, 1999) Ozmen, M; Sener, S; Mete, A; Kucukbay, HAnticholinesterase properties of 14 new synthesized organophosphorus (OP) compounds and four of their starting substances were tested in vitro and in vivo using electric eel acetylcholinesterase (AChE) and Rana ridibunda (frog of lowland) tadpoles, respectively. Gusathion-M(R) was used as a reference anti-AChE agent. Acetylcholinesterase inhibition capacity of tested compounds was assayed for 30-min period in vitro studies using electric eel AChE, of which 14 OP compounds inhibited enzyme activity more than 50% within 30 min, excluding Gusathion-M. However, four of the compounds inhibited AChE less than 50% during the test period. On the other hand, 12 of the OPs did not bring about mortality, whereas six of the tested compounds were found to be lethal agents for R. ridibunda tadpoles, for which values of concentration causing 50% lethality ranged from 14.42 to 89.95 ppm. Also, the highest degree of enzyme inhibition occurred by diethyl chlorophosphate (ETCP), which inhibited AChE activity 62% at 2.89 ppm in 24-h toxicity tests and which was more effective than Gusathion-M. The lethal OP compounds represented good correlation between dose and enzyme-inhibition capability in in vivo tests, but only ETCP showed such a relation for anti-AChE effect in both in vitro and in vivo conditions.Öğe New phosphorylated derivatives of piperidine and pyrrolidine(Marcel Dekker Inc, 1997) Sener, S; Mete, APhosphorylation reactions of piperidine and pyrrolidine with dialkyl chlorophosphates are described. Expected products are obtained in good yields at room temperature.Öğe Structure of C60-aliphatic diamine adducts(Marcel Dekker Inc, 1997) Ulug, A; Mete, A; Ulug, BProducts based on C-60 and aliphatic diamines are synthesized. Results indicate that C-60 molecules are partially connected to one another via aliphatic diamines, It is shown that d-spaces of the products can be varied by 50% when the number of C atoms in the aliphatic diamine is varied between 2 and 12. XRD analyses indicate that d-spaces are influenced by the repulsive interactions between C-60 molecules.Öğe Synthesis of C-60-furfural adduct(Marcel Dekker Inc, 1996) Mete, A; Ulug, A; Ulug, BDiels-Alder cycloaddition of furfural to C-60 in toluene has been realised. UV-VIS, FTIR and H-1-NMR investigations suggest that the conjugated structure of furfural was changed into a non-conjugated structure in the product.Öğe Synthesis of some heterocyclic phosphonates and their antibacterial and antifungal activities(Council Scientific & Industrial Res, 1999) Mete, A; Sener, S; Kücükbay, H; Günal, S; Durmaz, RFifteen heterocyclic phosphonate derivatives and their starting compounds have been evaluated in vitro for antibacterial and antifungal activities against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and yeast-like fungi; Candida albicans and Candida tropicalis. The compounds newly synthesised have been identified by H-1-NMR, FT-IR and micro analysis. Among the tested compounds 12, 13, 16, 17, 18, 22 and 23 are found effective to inhibit the growth of Candida albicans and Candida tropicalis at the MICs between 100-800 mu g/mL. The compounds tested here generally do not exhibit considerable antibacterial activity at the concentration studied (100-800 mu g/mL), except compound 18 which exhibits antibacterial activity against gram-positive bacteria at the MIC of 400 mu g/mL.
