Synthesis of some heterocyclic phosphonates and their antibacterial and antifungal activities
Küçük Resim Yok
Tarih
1999
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Council Scientific & Industrial Res
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Fifteen heterocyclic phosphonate derivatives and their starting compounds have been evaluated in vitro for antibacterial and antifungal activities against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and yeast-like fungi; Candida albicans and Candida tropicalis. The compounds newly synthesised have been identified by H-1-NMR, FT-IR and micro analysis. Among the tested compounds 12, 13, 16, 17, 18, 22 and 23 are found effective to inhibit the growth of Candida albicans and Candida tropicalis at the MICs between 100-800 mu g/mL. The compounds tested here generally do not exhibit considerable antibacterial activity at the concentration studied (100-800 mu g/mL), except compound 18 which exhibits antibacterial activity against gram-positive bacteria at the MIC of 400 mu g/mL.
Açıklama
Anahtar Kelimeler
Antimicrobial Activity, Derivatives, Benzimidazole
Kaynak
Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
38
Sayı
2
