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Öğe A case of Ewing's sarcoma in the mandible and the skull base.(2003) Kalcioglu M.T.; Oncel S.; Miman M.C.; Erdem T.; Mizrak B.A thirteen-year-old boy with Ewing's sarcoma was presented. The treatment was considerably delayed because of the initial diagnostic difficulties due to its insidious presentation and the unwillingness of the child's parents to further investigations and treatment. During a three-year delay, the tumor turned out to be a gross painful mass from a painless lesion. Cranial computed tomography and magnetic resonance imaging with contrast showed a destructive lesion extensively involving the right mandible and the skull base, with invasion to the intracranial space. Facial and intratemporal portions of the mass were removed totally, but the intracranial extension could not be totally excised because of cavernous sinus involvement. Histologic and immunohistochemical findings were consistent with the diagnosis of Ewing's sarcoma. The patient received systemic chemotherapy and radiotherapy following surgery. A month after radiation therapy, radiologic investigations showed a lung mass suggestive of metastasis. He died two days after hospitalization, from an intracranial hemorrhage associated with the intracranial mass.Öğe A case of necrotizing sialometaplasia in the upper lip.(2003) Kizilay A.; Erdem T.; Mizrak B.; Bayindir T.; Ozturan O.Necrotizing sialometaplasia is a benign, reactive, and self-limiting inflammatory disorder with clinical and histologic features resembling carcinoma. A fifty-eight-year-old woman presented with a firm submucosal mass on the right side of the upper lip, measuring 0.5 cm. Histopathologic examination of the incisional biopsy specimen was reported as adenoid cystic carcinoma, resulting in removal of the mass with a large excision and reconstruction of the primary site. However, final histopathologic diagnosis of the excised mass was necrotizing sialometaplasia. No recurrences occurred during a three-year follow-up. This report draws attention to the difficulty in distinguishing between necrotizing sialometaplasia and adenoid cystic carcinoma.Öğe Cerebral metastasis of mucoepidermoid carcinoma as the first clinical presentation: Detailed immunohistochemical evaluation(2008) Haltaş H.; Bozda? Z.; Engjn Aydin N.; Mizrak B.Mucoepidermoid carcinoma (MEC) is known as a lowgrade malignant tumor. Lymph node and distant metastases are only seen in the high grade variant of MEC. The patient, 52-year-old male, had progressive vision loss, urinary incontinence and weakness at the left side at first physical examination. Computed tomography scan demonstrated 4×3×4 cm mass at parafalcian region in the brain and an additional 2×2 cm mass at right lung field. The resected mass in the brain was 4.5 cm in diameter, solid, necrotic, pale gray tissue with irregular borders. Microscopically the tumor was composed of squamoid, intermediate and glandular cells. Mucicarmine, PAS-Alcian blue, carcinoembryonic antigen-monoclonal (CEA-M), cytokeratin 7 and 18 staining revealed glandular cells to whereas cytokeratin 8 was focally expressed in squamoid cells. Cytokeratin 20 and c-erb-B2 were negative in all of the tumor cells. This case is a low grade MEC metastasis which emphasizes the malignant potential of these tumors.Öğe Cyclin-D1 protooncogen expression in prostate cancer(2000) Özbek E.; Mizrak B.; Özbek M.; Büyükberber S.; Davarci M.Cyclin D1, a cell cycle regulator essential for G1 phase progression, has been implicated in the pathogenesis of certain cancers. High levels of these proteins have been reported in certain human malignancies and have been implicated in aberrant cell division and dysregulated tumor growth. In this study, 30 prostate cancer and 25 benign prostate tissues were studied for cyclin D1 expression using an immunohistochemical technique. All of the primary prostate cancer samples revealed regions of moderate to strongly positive nuclear staining for cyclin D1, however there was no nuclear staining in the benign prostate tissue except-weak staining in the stroma. There was a positive correlation between Gleason grade and staining intensity for cyclin D1. The increased expression of cyclin D1 in prostate cancer samples suggests that further studies on the expression of this gene and related genes may be of interest in understanding the pathogenesis of prostate cancer. The positive correlation between Gleason grade and protein expression may be used as a prognostic marker in prostate cancer. Further studies are needed to confirm this suggestion.Öğe An end-plate chondroma mimicking calcified lumbar disc herniation: A case report and review of the literature(1999) Erten S.F.; Koçak A.; Mizrak B.; Kutlu R.; Çolak A.The authors report a case of chondroma arising from a vertebral end- plate and mimicking lumbar disc herniation. This tumor became calcified within 2 weeks. It was completely removed surgically, after which the patient's symptoms were relieved and neurological deficits regressed.Öğe Endobronchial inflammatory pseudotumor: A cause of chronic cough(Asia Publishing Exchange Pte Ltd, 1999) Yildirim Z.; Soysal O.; Gokirma M.; Cihan H.B.; Mizrak B.; Hasanoglu H.C.Endobronchial location of an inflammatory pseudotumor is extremely rare. A 48-year-old female presented with chronic cough. An endobronchial polypoid inflammatory pseudotumor was diagnosed by bronchoscopic biopsy and treated by a middle lobectomy.Öğe Eosinophilic fasciitis - Progression to linear scleroderma. A Case Report(1999) Balat A.; Akinci A.; Turgut M.; Mizrak B.; Aydin A.Eoslnophilic fasciitis is a rare disease in children. Although changes similar to linear scleroderma have been reported, the outcome is usually good. In this report, a 10-year-old boy who developed eosinophilic fasciitis without a good response to steroids is presented. He progressed to linear scleroderma within months. Our case reinforces the hypothesis that eosinophilic fasciitis may be an early manifestation or a variant of localized scleroderma similar to the other cases in the literature.Öğe The factors affecting thermal necrosis secondary to the application of the Ilizarov transosseous wire(2005) Inan M.; Mizrak B.; Ertem K.; Harma A.; Elmali N.; Ayan I.OBJECTIVES: We investigated thermal changes associated with the application of the Ilizarov transosseous wires, the extent of necrosis, and the factors affecting necrosis. METHODS: We used a pair of tibiae from a 1-year-old cow. After removal of metaphyseal areas, each of four equal diaphyseal zones marked on both tibiae was drilled at 600, 900, 1,200 and 1,800 rpm, each time with a new wire. Heat changes were recorded with heat electrodes during the application and the speed of the wire was calculated. For histopathological examination, specimens were obtained at the access and exit sites to assess the extent of necrosis. Thermal changes between the zones and immediate and remote cortices were compared. The most significant factor affecting the heat changes was analyzed by linear regression. RESULTS: Heat changes varied between 48.4 degrees C (at 1,200 rpm) and 151.9 degrees C (at 600 rpm). The thickness of the immediate cortex, the time and speed for the wire to pass the cortex were found as significant parameters in heat changes (p=0.003, p=0.01, and p=0.01, respectively). A negative correlation was found between the speed of the wire and the thickness of the necrotic area (r=-0.901, p=0.001). Regression analysis showed that the time for the wire to pass through the cortex was the most significant factor in inducing heat changes in both cortices (p=0.001, p=0.003, respectively). Histopathologically, the extent of necrosis and bone erosion was associated with lower drill speeds. Necrosis was significantly notable in the immediate cortex than that of the remote one (p=0.006). CONCLUSION: Transosseous wires should be passed at high drill speeds and with earliest time elapses to reduce thermal necrosis.Öğe Öğe Metastatic spread of occult papillary carcinoma of the thyroid to the parapharyngeal space: a case report.(2003) Erdem T.; Miman M.C.; Oncel S.; Mizrak B.Metastasis from thyroid carcinomas to the parapharyngeal space is very rare. A forty-year-old male presented with progressive dysphagia and enlargement in the right upper neck. Examination showed medial displacement of the right palatine tonsil and the lateral oropharyngeal wall. A firm, submucosal mass measuring 4 x 3 cm was palpated. Computed tomography revealed a hypodense and heterogenic parapharyngeal mass with a calcified border. The mass was totally removed by a transcervical approach. Although frozen-section diagnosis was a benign lesion, histopathologic evaluation showed metastasis of papillary thyroid carcinoma to the parapharyngeal lymph nodes. Total thyroidectomy and bilateral selective neck dissection were performed, after which the tumor turned out to be papillary microcarcinoma (0.8 x 0.8 cm) in the right upper lobe of the thyroid gland. No locoregional recurrences or distant metastasis were observed during a three-year follow-up. The differential diagnosis of parapharyngeal masses should include metastatic thyroid carcinomas, for which a lymphatic route has been suggested between the thyroid gland and the parapharyngeal lymph nodes.Öğe A multicentric, hyaline vascular variant of Castleman's disease associated with B cell lymphoma: A case report(2009) Erkurt M.A.; Aydogdu I.; Kuku I.; Kaya E.; Mizrak B.; Basaran Y.Introduction: Three histological variants (hyaline vascular, plasma cell, and mixed) and two clinical types (localized and multicentric) of Castleman's disease have been described. The risk of progression to lymphoma is higher in multicentric Castleman's disease and is associated with poorer outcomes and higher mortality rate. Multicentric Castleman's disease often requires systemic therapy. Complete resection of the involved node in localized Castleman's disease is curative, with no reported recurrences. Case presentation: We report a case of a 66-year-old female with systemic symptoms and bilateral cervical lymph nodes which were initially diagnosed as the hyaline vascular variant of Castleman's disease and two years later after the initial diagnosis she was confirmed to B cell lymphoma. Following the treatment with radiation therapy to the cervical area and combination chemotherapy complete response was achieved. Conclusion: Although it has rarely been reported, the malignant potential of the Castleman's disease must be kept in mind. © 2009 Erkurt et al; licensee Cases Network Ltd.Öğe Potential toxicity of mitomycin C and 5-fluorouracili: An experimental study(1997) Tilgen F.; Er H.; Mizrak B.; Hepsen I.F.Purpose. To investigate potential loxicities of mitomycin C (MMC) and 5-Fluorouracil (5-FU) histologically after administration of subconjunctivally in 8 rabbits. Methods. In group 1 (8 eyes), the right eye of 4 rabbits received a single dose of 0.2 mL subconjunctival injection of O.I. 0.2, 0.4 and 0.6 nig/ mL and an equal volume of sterile saline in the left eye. In group 2, (8 eyes) 0.2 mL subconjunctival injection of 10.0 mg/mL 5-FU and 25 mg/mL 5-FU were performed in the right eye and in the left eye once daily for 5 days, respectively. The rabbits were killed at !, 20, 30, and 45 days after the last injections, the eyes were enucleated and studied histologically using light microscopy. Results. The congestion and edema in the ciliary body and iris, polymorphonuclear leukocytes (PMNs) infiltration at the limbus, and atrophy in the extraocular muscle were prominent in eyes injected, especially, 0.4 and 0.6 mg/mL MMC than the 5-FUinjected eyes. Conclusions. Subconjunctival injection of MMC even at moderate concentrations can be toxic to the ciliary body, thus a safe dose of a single subconjunctival injection of MMC appears to be 0.1 mg/mL or less. 5-FU is also required to use of much lower total dose of subconjunctival then used in the clinica! trial.Öğe Synchronous primary malignant neoplasms of colon and bladder.(2001) Sari R.; Buyukberber S.; Sevinc A.; Mizrak B.Extracolonic and synchronous malignancies are rare in colorectal carcinomas. We report a 68-year-old man with complaints of rectal bleeding and hematuria. Endoscopic biopsies revealed synchronous adenocarcinoma of the colon and transitional cell carcinoma of the bladder. The patient was started on chemotherapy, and is alive (with disease) nine months later.
