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    Effect of partially hydrolyzed synbiotic formula milk on weight gain of late preterm and term infants-a multicenter study
    (Frontiers Media Sa, 2023) Sahin, Suzan; Buyuktiryaki, Mehmet; Okur, Nilufer; Akcan, Abdullah Baris; Deveci, Mehmet Fatih; Yurttutan, Sadik; Gunes, Sezgin
    Introduction: Data on the effectiveness of hydrolyzed infant formula containing both pre- and probiotics (synbiotic formula) on the growth of infants is still scarce. This retrospective study was designed to evaluate the effect of a partially hydrolyzed synbiotic formula on growth parameters and the possible occurrence of major gastrointestinal adverse events or morbidities in infants born via cesarean section (C-section) delivery.Methods: C-section-delivered term and late preterm infants who received either partially hydrolyzed synbiotic formula, standard formula, or maternal milk and followed at seven different hospitals from five different regions of Turkey, during a 1-year period with a minimum follow-up duration of 3 months were evaluated retrospectively. All the included infants were evaluated for their growth patterns and any kind of morbidity such as diarrhea, constipation, vomiting, infection, or history of hospitalization.Results: A total of 198 infants (73 in the human milk group, 61 in the standard formula group, and 64 in the partially hydrolyzed synbiotic formula group) reached the final analysis. The groups were similar regarding their demographic and perinatal characteristics. No difference was observed between the three groups regarding gastrointestinal major side effects. Growth velocities of the infants in the human milk and partially hydrolyzed synbiotic formula groups during the first month of life were similar whereas the weight gain of infants in the standard formula group was significantly less than these two groups (p < 0.001). Growth velocities were similar among the three groups between 1st and 3rd months of age.Discussion: A partially hydrolyzed synbiotic formula provided better weight gain in late-preterm and term infants who were delivered via C-section delivery compared to the standard formula during the first month of life. This weight gain was similar to the infants receiving exclusively human milk. This difference was not observed in length and head circumference gain. No difference was observed in any of the parameters during the 1st-3rd months of age. Specially formulated partially hydrolyzed synbiotic formulas may reverse at least some of the negative impacts of C-section delivery on the infant and help to provide better growth, especially during the early periods of life.
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    The effect of using animations on pre-service science teachers' science achievement
    (Elsevier Science Bv, 2010) Unal, Ibrahim; Okur, Nilufer; Kapucu, Serkan
    In this study, the effect of animation technique on the learning of properties of electromagnetic waves (EMWs) for pre-service science teachers has been investigated. The research has been carried out for two weeks on 2(nd) grade pre-service science teachers. This study has been carried out with experimental and control groups consisted of 70 students in total. 35 students were randomly assigned to experimental group and control group respectively. The achievement test was given to both groups before and after the treatment. Significant difference has been found between the experimental group and control group (p<0.05). (c) 2010 Elsevier Ltd. All rights reserved.
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    Postnatal hydrocortisone therapy for the treatment of bronchopulmonary dysplasia in very low birth weight infants
    (2019) Buyuktiryaki, Mehmet; Alyamac Dizdar, Evrim; Okur, Nilufer; Sari, Fatmanur; Bezirganoglu, Handan; Canpolat, Fuat Emre; Uras, Nurdan; Oguz, Serife Suna
    Aim: Corticosteroids are widely used to prevent and treat bronchopulmonary dysplasia (BPD) due to their strong anti-inflammatory effects. We aim to evaluate the outcomes of late onset systemic hydrocortisone (HC) therapy in very low birth weight infants with BPD.Material and Methods: The medical records of 706 preterm infants with gestational age ≤ 30 weeks over a 4-year period were retrospectively reviewed. Infants who required invasive/noninvasive respiratory support or ≥ 30% oxygen due to BPD and were treated with HC after the third postnatal week were included. The infants were divided into 3 groups according to respiratory support at the beginning of the HC treatment: mechanical ventilation (MV), noninvasive ventilation (NIV), and free oxygen.Results: Seventy-six (11.9%) infants in our cohort received HC therapy. In the MV group, 83.3% of the infants were successfully extubated after a median of 4 days (interquartile range [IQR], 2-8 days). In the NIV group, 83.9% of the infants required no longer respiratory support after a median of 6 days (IQR, 3-16 days). In the free oxygen group, none of the infants needed supplemental oxygen after a median of 8 days (IQR, 6-12 days). Conclusion: Late HC therapy facilitates extubating without adverse short-term effects, reduces the need of invasive and noninvasive ventilation, and facilitates discharge without supplemental oxygen.