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Öğe The association between C-reactive protein and metabolic syndrome components(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2007) Kural, Alev; Koldaş, Macit; Seval, Hatice; Omma, Ahmet; Yiğit, NamıkÖz:Giriş: İnsülin direnci metabolik sendrom ile ilişkilidir ve kardiyovasküler hastalıklar için risk faktörüdür. C-Reaktif protein (CRP) gelecekteki kardiyovasküler hastalıkların habercisi olan bir proinflamatuar belirteçdir. Biz bu çalışmada insülin direnci ile CRP düzeylerinin ilişkisini ve CRP’nin metabolik sendromda kriter olup olmayacağını araştırdık. Gereç ve Yöntem: Bu çalışmaya metabolik sendrom tanısı almış 63 hasta ile 20 sağlıklı kontrol grubu dahil edildi. Açlık kan glukoz seviyeleri, insülin ve CRP düzeyleri ölçüldü. İnsülin dirençleri (Homeostasis Model Assessment=HOMA-IR) formülü kullanılarak değerlendirildi. Bulgular: Metabolik sendromlu hasta grubu ile kontrol grubu arasında bel çevresi, açlık glukozu, insülin ve CRP değerleri arasında istatistiksel anlamlı farklılıklar vardı. Hasta grubunda açlık glukoz düzeyleri ve CRP arasında (P=0,0001, r=0,3) ve HOMA-IR ile CRP arasında (P=0,007, r=0,29) zayıf fakat anlamlı bir ilişki vardı. Sonuç: CRP’nin metabolik sendromun tanı ve takibinde önemli bir parametre olduğu sonucuna vardık.Öğe Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?(Sciendo, 2021) Kucuk, Adem; Baykara, Rabia Aydogan; Tuzcu, Ayca; Omma, Ahmet; Cure, Medine Cumhur; Cure, Erkan; Acet, Gunseli KaracaIntroduction. Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B-12 (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and methods. The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results. The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions. There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis.Öğe CRP ile Metabolik Sendrom Arasındaki İlişki(İnönü Üniversitesi Tıp Fakültesi Dergisi, 2007) Kural, Alev; Koldaş, Macit; Seval, Hatice; Omma, Ahmet; Yiğit, Namıkİnsülin direnci metabolik sendrom ile ilişkilidir ve kardiyovasküler hastalıklar için risk faktörüdür. C-Reaktif protein (CRP) gelecekteki kardiyovasküler hastalıkların habercisi olan bir proinflamatuar belirteçdir. Biz bu çalışmada insülin direnci ile CRP düzeylerinin ilişkisini ve CRP’nin metabolik sendromda kriter olup olmayacağını araştırdık. Gereç ve Yöntem: Bu çalışmaya metabolik sendrom tanısı almış 63 hasta ile 20 sağlıklı kontrol grubu dahil edildi. Açlık kan glukoz seviyeleri, insülin ve CRP düzeyleri ölçüldü. İnsülin dirençleri (Homeostasis Model Assessment=HOMA-IR) formülü kullanılarak değerlendirildi. Bulgular: Metabolik sendromlu hasta grubu ile kontrol grubu arasında bel çevresi, açlık glukozu, insülin ve CRP değerleri arasında istatistiksel anlamlı farklılıklar vardı.Hasta grubunda açlık glukoz düzeyleri ve CRP arasında (P=0,0001, r=0,3) ve HOMA-IR ile CRP arasında (P=0,007, r=0,29) zayıf fakat anlamlı bir ilişki vardı. Sonuç: CRP’nin metabolik sendromun tanı ve takibinde önemli bir parametre olduğu sonucuna vardık.Öğe Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method(Kare Publ, 2019) Baykara, Rabia Aydogan; Tuzcu, Ayca; Omma, Ahmet; Acet, Gunseli Karaca; Dogan, Erdal; Aydin, Almila; Cure, Medine CumhurOBJECTIVE: Increased reactive oxygen species may play an important role in Ankylosing spondylitis (AS) etiopathogenesis. The thiol group is a very potent antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with AS by evaluating thiol/disulfide homeostasis. METHODS: In this study, a total of 66 AS patients (27 male, 39 female) and 66 healthy controls (21 male, 45 female) were enrolled. Recently, a novel method for the thiol measurement was found. Thiol and disulfide values were measured by the novel methods. RESULTS: Native thiol (NT) (p<0.001) and native thiol/total thiol (NTT) (p<0.001) levels of AS patients were significantly lower compared to the values of the healthy group. However, disulfide (p<0.001), disulfide/native thiol (DNT) (p<0.001) and disulfide/total thiol (DTT) levels of AS patients were a strongly higher control group. A negative correlation was found between BASFI and NTT. Also, a negative correlation was found between BASDAI and NT, NTT levels. A positive correlation was found between BASFI and disulfide, DNT and DTT levels. A positive correlation was found between BASFI and disulfide, DNT and DTT levels. CONCLUSION: The findings revealed that thiol-disulfide homeostasis deteriorated in patients with AS in favor of disulfide amounts. Thiol-disulfide homeostasis can play roles in the etiology and severity of AS.Öğe The relationship of serum visfatin levels with clinical parameters, flow-mediated dilation, and carotid intima-media thickness in patients with ankylosing spondylitis(Tubitak Scientific & Technological Research Council Turkey, 2021) Aydogan Baykara, Rabia; Kucuk, Adem; Tuzcu, Ayca; Tuzcu, Goksel; Cure, Erkan; Uslu, Ali Ugur; Omma, AhmetBackground/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods: Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods. Results: Visfatin levels of the patients were significantly higher than controls (p < 0.001). FMD values in patients with AS were significantly lower (p = 0.007) whereas cIMT were significantly higher than the controls (p = 0.003). There was a negative relationship between FMD with visfatin levels (p = 0.004), BASDAI (p = 0.010), and BASFI (p = 0.007). There was a positive relationship between cIMT with visfatin (p = 0.005), BASDAI (p < 0.001), and BASFI (p < 0.001). There was a positive relationship between visfatin with BASDAI (p < 0.001), and BASFI (p < 0.001). Conclusion: Visfatin levels are increased and associated with impaired FMD and increased cIMT in patients with AS. Increased visfatin levels may be associated with subclinical atherosclerosis in AS.Öğe Thiol/Disulfide homeostasis in patients with rheumatoid arthritis(De Gruyter Poland Sp Zoo, 2019) Tuzcu, Ayca; Baykara, Rabia Aydogan; Omma, Ahmet; Acet, Gunseli Karaca; Dogan, Erdal; Cure, Medine Cumhur; Sandikci, Sevinc CanBackground. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. Conclusion. We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.
