Thiol/Disulfide homeostasis in patients with rheumatoid arthritis
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
De Gruyter Poland Sp Zoo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. Conclusion. We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.
Açıklama
Anahtar Kelimeler
Rheumatoid arthritis, thiol, disulfide, thiol/disulfide homeostasis, oxidative stress
Kaynak
Romanian Journal of Internal Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
57
Sayı
1
