Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

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dc.authoridAydogan Baykara, Rabia/0000-0003-0542-266X
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.authoridCüre, Erkan/0000-0001-7807-135X
dc.authoridCure, Medine Cumhur/0000-0001-9253-6459
dc.authoridSandikci, Sevinc Can/0000-0001-5921-8029
dc.authorwosiddoğan, erdal/ABI-7249-2020
dc.authorwosidAydogan Baykara, Rabia/ACI-5046-2022
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.authorwosidCüre, Erkan/W-4922-2017
dc.authorwosidCure, Medine Cumhur/A-1089-2018
dc.authorwosidSandikci, Sevinc Can/AAE-7267-2021
dc.contributor.authorTuzcu, Ayca
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorOmma, Ahmet
dc.contributor.authorAcet, Gunseli Karaca
dc.contributor.authorDogan, Erdal
dc.contributor.authorCure, Medine Cumhur
dc.contributor.authorSandikci, Sevinc Can
dc.date.accessioned2024-08-04T21:02:16Z
dc.date.available2024-08-04T21:02:16Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis. Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods. Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients. Conclusion. We found that the thiol-disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.en_US
dc.identifier.doi10.2478/rjim-2018-0025
dc.identifier.endpage36en_US
dc.identifier.issn1582-3296
dc.identifier.issn2501-062X
dc.identifier.issue1en_US
dc.identifier.pmid30375356en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.2478/rjim-2018-0025
dc.identifier.urihttps://hdl.handle.net/11616/104611
dc.identifier.volume57en_US
dc.identifier.wosWOS:000463772500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofRomanian Journal of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectthiolen_US
dc.subjectdisulfideen_US
dc.subjectthiol/disulfide homeostasisen_US
dc.subjectoxidative stressen_US
dc.titleThiol/Disulfide homeostasis in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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