Yazar "Otlu A." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    The effect of chronic alcohol consumption on pancreas mast cells of rats
    (2002) Vardi N.; Otlu A.; Öztürk F.
    Purpose: In this study the effect of chronic alcohol consumption on pancreas mast cells of rats was investigated at light microscopic levels. Material and Methods: The study was performed on male Wistar albino rats. The experimental group was fed with a modified liquid diet (MLD) containing 7.2 % ethanol for 2,4 and 6 months. Control rats were fed on isocaloric MLD with no ethanol. At the end of the experimental feeding period, samples were fixed in Bouin solution. The sections were stained with Heamatoxylen-Eosin and Toluidin Blue methods. Results: This study revealed that the number of mast cells was significantly reduced in the alcoholic group when compared with the control group. Mast cells also showed degranulation in the experimental group. Conclusion: We conclude that alcohol induced the secretion of mast cell mediators in the pancreas of the alcohol fed rats.
  • Küçük Resim Yok
    Öğe
    Improving effects of aminoguanidine on the histologic alterations in rat kidneys in diabetes
    (Turkiye Klinikleri, 2006) Vardi N.; Iraz M.; Gül M.; Öztürk F.; Uçar M.; Otlu A.
    Objective: This study was designed to investigate the improving effects of aminoguanidine on renal histological alterations in a streptozotocin (STZ)- induced diabetic rat model. Material and Methods: Fifteen Sprague-Dawley adult female rats were divided into three groups: control, diabetic (D) and diabetic treatment with aminoguanidine (DAG) groups. Experimental diabetes was induced by a single intraperitoneal dose of STZ (45 mg/kg). In the DAG group, AG was added in the drinking water (1 gr/L) after administration of STZ. This was maintained until the end of the study (for 8 weeks). At the end of the experiment, blood glucose levels were determined and after the routine tissue follow-up process, kidneys were embedded in paraffin. Histochemical and immunohistochemical stains were applied and the specimens were examined with light microscope. Results: After 8 weeks, the rats in diabetes group had significantly lower body weight and significantly higher blood glucose levels than the rats of control and DAG groups. The main histological changes resulting from diabetes were detected in glomerular and tübüler basal membrane and epithelial cells (glycogen accumulation, swelling and vacuolization). We observed the improving effects of aminoguanidine treatment on rat kidney. Conclusion: In conclusion, chronic administration of aminoguanidine reduced renal injury in STZ- induced diabetic rats. Therefore, we believe that aminoguanidine may be used to prevent development of diabetic renal damage. However, further studies are needed to elucidate the mechanisms of the improving effect of aminoguanidine on diabetic complications. Copyright © 2006 by Türkiye Klinikleri.