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Ameliorative Effects of Resveratrol on Acute Ovarian Toxicity Induced by Total Body Irradiation in Young Adult Rats
(Elsevier Science Inc, 2012) Simsek, Yavuz; Gurocak, Simay; Turkoz, Yusuf; Akpolat, Nusret; Celik, Onder; Ozer, Ali; Yilmaz, Ercan
Objective: The purpose of this study was to investigate the ovarian protective effects of resveratrol in rats exposed to total body irradiation. Design: Experimental study. Settings: University hospital. Participants and Interventions: Thirty female rats were randomized into four groups: (1) control group (n = 7); (2) low-dose (10 mg/kg) resveratrol group (n = 8); (3) high-dose (100 mg/kg) resveratrol group (n =7); and (4) sham irradiation group (n = 8). The drugs were administered intraperitoneally as single doses, and the rats were exposed to total body radiation 24 h after the treatment. The animals were sacrificed the following day, and their ovaries were excised for histopathological and biochemical analysis. Main Outcome Measures: The ovarian follicle counts were calculated, and irradiation-dependent ovarian damage and tissue levels of antioxidant enzymes were evaluated. Results: Group 2 and Group 3 showed significantly higher numbers of total follicle counts compared with Group 1 (P < 0.01). The low-dose resveratrol treatment was associated with significantly higher numbers of primary follicles than the high-dose group. The tissue activities of glutathione peroxidase (GsH-Px) and catalase (CAT) were significantly elevated in the resveratrol-treated animals. Evaluation of ovarian histology revealed no remarkable changes in fibrosis and leucocyte infiltration among the resveratrol-treated and control rats; however, vascularity was significantly reduced in the high-dose group (P = 0.014). Conclusion: Resveratrol attenuated irradiation-dependent ovarian damage, suggesting that this natural antioxidant is effective in reducing the follicle loss induced by ionizing radiation.
The approach of smokers to the new tobacco law and the change in their behaviour
(Turkish Assoc Tuberculosis & Thorax, 2012) Atilla, Nurhan; Koksal, Nurhan; Ozer, Ali; Kahraman, Hasan; Ekerbicer, Hasan
Introduction: The aim of our study is; to assess the approach of smokers to tobacco law, examine changes in their smoking related behaviors after the new law and determine the factors associated with these changes. Materials and Methods: Data collected by questionnaire including 30 question. We applied the questionnaire to 1509 current smokers, and ex-smokers who quitted smoking after the law. SPSS packet programme was used for analyses. Results: Participants consisted of 419 (28.0%) female, 1090 (72.0%) male with an average age of 33.6 +/- 10.5 years. Although 80% of them knew that passive smoking is harmful to non-smokers, rate of smoking at home and in the car were very high. 869 (58.0%) of participants supported the law. 87 (5.8%) smokers quitted smoking after the law, 316 (20.9%) reduced. While health problems (37.3%) were the most frequent reason for quitting, restriction of smoking area had the most effect to reduce (54.2%). Conclusion: We satisfied that; the new tobacco law encouraged smokers to quit smoking. In addition, the majority of smokers supported the law.
ASSESSMENT OF A DIABETES EDUCATION PROGRAM ON KNOWLEDGE OF DIABETES AMONG DIABETICS ATTENDING A GOVERNMENT HOSPITAL IN TURKEY
(Southeast Asian Ministers Educ Organization, 2019) Soylar, Pinar; Ozer, Ali
It is important for diabetics to understand their disease and how to prevent its complications. The aim of this study was to assess the efficacy of a diabetes education program on knowledge of diabetes among diabetic patients attending a government hospital in Turkey in order to inform program organizers about deficiencies and strengths of the program and how to improve it. A multidisciplinary team at a government hospital developed a diabetes educational program for diabetic patients following the 5 modules of the Turkey Diabetes Program (2015-2020). The study subjects consisted of patients with diabetes mellitus type 2 (T2DM) attending the diabetes outpatient clinic, Malatya State Hospital and were willing to participate in the all sessions of the education program and willing to complete the pre- and post-program questionnaire. All the eligible subjects were invited to participate (n=276) whom 185 completed the program and filled out the questionnaire. The mean [+/- standard deviation (SD)] age of study subjects was 56.3 (+/- 9.9) years; 54.6% males. The mean questionnaire score prior the program was 6.3 points and after the program was 11.7 points; this difference was significant (p<0.001). The mean questionnaire score in males prior to the program (6.6 points) was significantly higher (p=0.020) than the female subjects (6.0 points) but after the program the mean questionnaire score among males (11.8 points) was not significantly higher than the female subjects (11.5 points) (p=0.334). The mean questionnaire score prior to program among subjects with a higher education level (7.2 points) was significantly higher (p=0.002) than among subjects with a lower education level (5.9 points) but the questionnaire score after the program among subjects with a higher education level (11.9 points) was not significantly different (p=0.323) from those with a lower education level (11.6 points). We conclude the diabetes education program was effective in improving knowledge about T2DM and it corrected disparities in knowledge level by gender and education level. Further studies are needed to determine if this improved in knowledge level is retained over time and if it results in a measurable effect on the level of diabetes control and the prevelance of complications.
Assessment of Knowledge and Attitudes Toward Organ Donation Among School Teachers: First National Survey Study
(Elsevier Science Inc, 2022) Akbulut, Sami; Ozer, Ali; Firinci, Betul; Demyati, Khaled; Saritas, Hasan; Yilmaz, Sezai
Background and aim. The most important factors affecting organ donation are socioeconomic, educational, and cultural factors. The aim of this study was to evaluate the attitudes, knowledge levels, and behaviors of school teachers toward organ donation Methods. This study surveyed 2400 school teachers working in official public schools. Turkey was divided into 26 regions based on the similarity of social, economic, and geographic factors identified by the Turkish Statistical Institute. Teachers were distributed equally in the city center and towns based on population. The survey procedures were carried out using computer-assisted personal interviewing. Results. Among teachers, 89.6% had a bachelor's degree and 8.5% had a master's degree. In addition, 32.5% worked in primary schools, 33.1% worked in secondary schools, and 34.4% worked in high schools. Furthermore, 0.7% had donated an organ; 66.5% were not considering organ donation in the future, of whom 9.0% indicated religion as the reason for not donating an organ, and 34.8% did not indicate any reason. In addition, 96.6% considered organ donation to be proper behavior for humanity and 68% believed that organ donation is appropriate in religious terms. Conclusions. This study showed that school teachers have inadequate knowledge and attitudes toward organ donation. Encouraging children and adolescents to make a well-informed decision about organ donation and to register this choice will depend largely on preparing school teachers with adequate knowledge and motivation toward creating generations with a positive attitude toward organ donation.
Assessment of Patient Safety Attitude Levels Among Healthcare Professionals Working in the Operating Room
(Erciyes Univ Sch Medicine, 2023) Tamer, Murat; Akbulut, Sami; Cicek, Ipek Balikci; Saritas, Hasan; Akbulut, Mehmet Serdar; Ozer, Ali; Colak, Cemil
Objective: This study aims to determine the factors affecting the perception levels of operating room (OR) nurses and nurse anesthetists working in the OR regarding patient safety attitudes. Materials and Methods: This study was conducted using face-to-face interviews with 117 healthcare professionals working as OR nurses (n=60) and nurse anesthetists (n=57). The patient safety attitude questionnaire (SAQ), where the reliability analysis was also performed for the SAQ scale. and sociodemographic characteristics were used for this study. Qualitative variables were given as numbers and percentages (%), and the dataset belonging to quantitative variables that met the normal distribution criteria was given as mean (standard deviation), and data of quantitative variables that did not comply with nor-mality were given as median, IQR, and 95% CI of the median.Results: There were significant differences between OR nurses and nurse anesthetists regarding job satisfaction (p=0.015) and total SAQ score (p=0.040). Significant differences were detected between men and women participants regarding smoking (p=0.020) and stress recognition (p=0.040). The reliability analysis of the scale was as follows: total (alpha: 0.791), job satisfaction (alpha: 0.883), teamwork climate (alpha: 0.856), safety climate (alpha: 0.864), perceptions of management (alpha: 0.881), stress recognition (alpha: 0.791), and working conditions (alpha: 0.530).Conclusion: It was shown that the patient safety attitudes of the healthcare professionals participating in this study are above average, although it is still insufficient, where the stress identification score of the female participant was higher, and it was also found that the nurses' job satisfaction and SAQ score were higher.
Assessment of Temperament and Character Profile with Anxiety and Depression in Patients with Acne
(Galenos Publ House, 2013) Ozturk, Perihan; Orhan, Fatma Ozlem; Ozer, Ali; Karakas, Tugba; Oksuz, Ali Nuri; Yetisir, Nur Yalcin
Background: Acne is the most common skin disease, affecting nearly 85% of the population as well as their lives. Acne can severely affect social and psychological functioning. Patients with acne may have anxiety, depression, decreased self-esteem, interpersonal difficulties, unemployment, social withdrawal, and even suicidal intent. Aims: The aim of this study was to evaluate the temperament and character inventory (TCI) of patients with acne and to compare the results with those of healthy controls. Study Design: Case-control study Methods: The study population consisted of 47 patients with acne, and 40 healthy control subjects. All participants were instructed to complete a self-administered 240-item TCI and the Hospital Anxiety and Depression Scale. Results: In this study, the scores for the temperament properties Worry and pessimism (HA1) and Dependence (RD4) and the character properties Social acceptance (C1) and Integrated conscience (C5) were found to be higher in acne patients than in healthy controls (p<0.05). Compared to the controls, depression and anxiety scores were found to be markedly higher in the patients with acne. Acne type correlated positively with the Disorderliness (NS4) subscale of Novelty seeking (NS) and anxiety. Additionally, acne type correlated negatively with the Attachment (RD3) subscale of Reward Dependence (RD), with the Transpersonal identification (ST2) and Spiritual acceptance (ST3) subscales of Self-Trancendence (ST), and with the Compassion (C4) subscale of Cooperativeness (C). Conclusion: Studies in this area may lead to the development of specific and focused interventions for TCI in patients with acne vulgaris. We suggest that the evaluation and treatment of acne should also include psychosomatic approaches in clinical practice.
Attitudes, awareness, and knowledge levels of the Turkish adult population toward organ donation: Study of a nationwide survey
(Baishideng Publishing Group Inc, 2020) Akbulut, Sami; Ozer, Ali; Gokce, Ayse; Demyati, Khaled; Saritas, Hasan; Yilmaz, Sezai
BACKGROUND The most important factors affecting attitudes on organ donation are socioeconomic, educational, cultural, and religious factors in many countries. AIM To evaluate the attitudes, awareness, and knowledge levels of the Turkish adult population toward organ donation. METHODS This nationwide study surveyed 3000 adults (>= 18 years) in Turkey. To ensure a representative sample, the Nomenclature of Territorial Units for Statistics-II (modified for Turkey) was used. Turkey was divided into 26 regions based on social, economic, and geographic criteria as identified by the Turkish Statistical Institute. A stratified sampling method was used with an even distribution of adults across cities and towns based on population data. Data were collected by the PRP Research and Consultancy Company using computer-assisted personal interviews. RESULTS Out of 3000 individuals represented in the study population, 1465 (48.8%) were male and 1535 (51.2%) female. The results showed that most participants were under 45 years (59.0%) and married (72.1%), some had a bachelor's degree or higher (21.9%), and very few (1.5%) had any direct experience with organ transplantation - whether in the family, or a family member on a transplantation waiting list. Most of the study population (88.3%) had not considered donating an organ, however, most (87.9%) said that they would accept an organ from a donor if they needed one. Among the individuals surveyed, 67% were willing to donate an organ to a close relative, while 26.8% would donate an organ to an unrelated person. Only 47.2% said they had adequate information about brain death, and 85.2% refused to consent to donating organs of family members declared brain dead. Only 33.9% thought they had adequate information about organ donation. The main source of information was the television. The two main reasons for refusing organ donation were that it was too soon to think about organ donation and the importance of retaining the integrity of the dead person's body. CONCLUSION This study showed that Turkey's adult population has inadequate knowledge about organ donation. The study advocates for public education programs to increase awareness among the general population about legislation related to organ donation.
Attitudes, knowledge levels and behaviors of Islamic religious officials about organ donation in Turkey: National survey study
(Baishideng Publishing Group Inc, 2020) Akbulut, Sami; Ozer, Ali; Firinci, Betul; Saritas, Hasan; Demyati, Khaled; Yilmaz, Sezai
BACKGROUND The most important factors affecting the decision of organ donation are socioeconomic, educational, cultural, and religious factors. AIM To evaluate Islamic religious officials' attitudes and behaviors toward and level of knowledge on organ donation and transplantation. METHODS This study surveyed 2350 Islamic religious officials in Turkey. To ensure a representative sample, we used and modified the Nomenclature of Territorial Units for Statistics. Based on the Nomenclature of Territorial Units for Statistics-II, Turkey was divided into 26 regions. The number of Islamic religious officials in each city and town in each of the 26 regions was proportionate to the population. A stratified sampling method based on demographic factors, such as age, marital status, and educational level, was used. Data were collected by PRP Research and Consultancy Company using computer-assisted personal interviewing. RESULTS Of the 2350 religious officials surveyed, 59.9% were in the age group of 35-54 years; 84.7% had either a bachelor's or a master's degree; 99.7% never donated an organ; and 75.4% were not considering donating in the future. About 22% of the religious officials said religious belief was their reason for not donating; 45.3% did not indicate any reason. Although 41.5% of participants considered cadaveric organ donation as the best source of organ transplantation, 36.3% deemed living donor transplantation as the best option. Meanwhile, 52.9% of participants considered donating an organ from a brain dead relative in case they were asked for permission; 80.1% considered donating to a relative, if necessary; 81.6% considered undergoing organ transplantation, if necessary. About 83.7% of participants deemed organ donation as a proper human behavior; 60.5% believed that it is allowed by Islam; 55% said they preach for organ donation at their mosque; and 41.1% said their views of organ donation were influenced by their leaders in society. CONCLUSION Religious officials are unsure whether or not organ donation is respectful of their religious belief, but they consider donating an organ if a relative need to undergo organ transplantation.
Communication Skills, Empathic Tendency and Affecting Factors of Assistant Doctors in Inonu Universty, Faculty of Medicine, Malatya
(Medicine Science, 2015) Bozkir, Cigdem; Tekin, Cigdem; Mete, Burak; Nacar, Erkay; Ozer, Ali
Öz: Bu araştırma, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan asistan doktorların iletişim becerileri ve empatik eğilim düzeylerini belirlemek amacıyla yapılmış tanımlayıcı tipte bir araştırmadır. Araştırma, 2013 yılı Ekim-Aralık döneminde, Malatya İnönü Üniversitesi Tıp Fakültesinde ihtisas yapan 261 asistan doktor üzerinde gerçekleştirilmiştir. Çalışmada araştırmacı tarafından geliştirilen, demografik özellikler ile çalışma düzenlerini sorgulayan anket formu ve Balcı (1996) tarafından geliştirilmiş olan iletişim becerileri ölçeği (İBÖ) ve Dökmen tarafından geliştirilen empatik eğilim ölçeği (EEÖ) kullanılmıştır. Veriler, SPSS paket programı kullanılarak analiz edilmiştir. İstatistiksel analizlerde, yapılan Kolmogorov-Smirnov test (K-S) ile normal dağılıma uyan veriler için Student t ve One Way Anova testleri kullanılmış, normal dağılıma uymayan veriler için ise Mann-Whitney U ve Kruskall Wallis testleri kullanılmış ve tüm değerlendirmelerde p<0.05 düzeyi anlamlı kabul edilmiştir. Araştırmaya katılan asistanların %41.8'i kadın, %58.2'si erkektir. Araştırmaya katılan asistan doktorların sosyo demografik özelliklerine göre iletişim becerileri ölçeği ve alt ölçeklerinden aldıkları puanlarda anlamlı bir farklılık bulunmamıştır (p>0.05). Empatik eğilim ölçeğinden alınan puan ortalamaları, temel bilimlerde çalışanlarda; 61.33±5.50, dâhili bilimlerde çalışanlarda; 63.54±7.38, cerrahi bilimlerde çalışanlarda ise 64.00±5.76 olup aradaki farklılık istatiksel olarak anlamlı bulunmamıştır (p> 0.05). Araştırmaya katılan asistan doktorların empatik eğilim ölçeği ve iletişim becerileri ölçeği puanları arasında anlamlı bir korelasyon bulunmuştur (r=0,276; p<0.01). Elde edilen bu değerler sonucunda İnönü Üniversitesi Tıp Fakültesi asistan hekimlerinin iletişim becerileri ve empatik eğilim düzeylerinin "orta düzey" olduğu, temel bilimlerde çalışan hekimlerin çalışma ortam memnuniyetlerinin daha yüksek olduğu saptanmıştır
Comparison of keypads and touch-screen mobile phones/devices as potential risk for microbial contamination
(J Infection Developing Countries, 2015) Koroglu, Mehmet; Gunal, Selami; Yildiz, Fatma; Savas, Mehtap; Ozer, Ali; Altindis, Mustafa
Introduction: Touch-screen mobile phones/devices (TMPs/Ds) are increasingly used in hospitals. They may act as a mobile reservoir for microbial pathogens. The rates of microbial contamination of TMPs/Ds and keypad mobile phones (KMPs) with respect to different variables including use by healthcare workers (HCWs)/non-HCWs and the demographic characteristics of users were investigated. Methodology: A total of 205 mobile phones/devices were screened for microbial contamination: 76 devices belonged to HCWs and 129 devices belonged to the non-HCW group. By rubbing swabs to front screen, back, keypad, and metallic surfaces of devices, 444 samples were collected. Results: Of 205 mobile phones/devices, 143 (97.9%) of the TMPs/Ds and 58 (98.3%) of the KMPs were positive for microbial contamination, and there were no significant differences in contamination rates between these groups, although TMPs/Ds had significantly higher microbial load than KMPs (p < 0.05). The significant difference in this analysis was attributable to the screen size of mobile phones >= 5 ''. Microbial contamination rates increased significantly as phone size increased (p < 0.05). Higher numbers of coagulase-negative Staphylococci (CNS) were isolated from KMPs than TMPs/Ds (p = 0.049). The incidence of Enterococcus spp. was higher on the KMPs of HCWs, and methicillin resistant CNS was higher from the TMPs/Ds of non-HCWs (p < 0.05). Isolation of CNS, Streptococcus spp. and Escherichia coli was higher from the TMPs/Ds of HCWs (p < 0.05). Conclusions: We found no significant difference between TMP/Ds and KMPs in terms of microbial contamination, but TMP/Ds harboured more colonies and total microbial counts increased with screen size.
Correlation of clinical, endoscopic, and histological findings with virulence factors in children with Helicobacter pylori gastritis
(Lippincott Williams & Wilkins, 2014) Selimoglu, Mukadder A.; Karabiber, Hamza; Otlu, Baris; Yildirim, Ozge; Ozer, Ali; Samdanci, Emine
Background and goals As there are limited data regarding the correlation between virulence factors and clinical, endoscopic, and histological findings in children with Helicobacter pylori gastritis, we aimed to evaluate that probable relationship in pediatric cases. Study One hundred and fifty-nine children with chronic abdominal pain or dyspepsia were included in this study. Upper gastrointestinal endoscopy was performed and multiple biopsy samples were taken from the esophagus, the antrum, and the duodenum. PCR was used for the determination of virulence factors. Results According to PCR analysis, 98 (61.6%) children were positive for H. pylori. Using histopathological examination and culture, H. pylori was detected in 65 (40.9%) and 51 (32.1%) children, respectively. Peptic ulcer prevalence and histopathological features were not different among cagA, cagE, or iceA1 positive and negative groups (P > 0.05). Peptic ulcer prevalence and histopathological findings were more common in iceA2-positive patients (P < 0.05). Antral nodularity was more common in cagA-positive patients (P < 0.05). Endoscopic and histological features were not different among patients with or without m1 or m2 strains (P > 0.05). S1b positivity was associated with a higher esophagitis rate (P < 0.05). Conclusion Among virulence factors, iceA2 was associated with peptic ulcer and milder histopathological findings, and vacAs1 was associated with milder histopathological findings.
Current laparoscopic practice patterns among urologists in Turkey
(Aves, 2012) Altunoluk, Bulent; Soylemez, Haluk; Ozer, Ali; Efe, Erkan; Sancaktutar, Ahmet Ali; Resim, Sefa
Objective: Laparoscopic surgery has become increasingly popular in urology over the last decade. This survey was performed to evaluate the current practice patterns in laparoscopy among urologists in Turkey. Material and methods: A detailed questionnaire about urologic laparoscopic practice patterns was distributed to 1242 urologists who were working in Turkey. The questions pertained to age, practice demographics, and the amount and variety of laparoscopy performed. Results: Nearly half of the respondents (48.3%) already performed laparoscopy. Of the urologists in academic settings, including university hospitals and education and research hospitals, 69.6% and 59.4% performed laparoscopy, respectively. In state hospitals, the percentage of those who performed laparoscopy was lower (26.9%). The most important reasons mentioned for performing laparoscopy were shorter hospital stay, patient requests and greater flexibility of possible surgical techniques. The main laparoscopic procedures performed were nephrectomy (benign indication), 91%; renal cyst decortications, 90%; nephrectomy (malign indication), 65%; laparoscopic stone surgery, 47% and pyeloplasty, 38%. A large percentage (77.2%) of respondents intended to attend continuing education and to perform laparoscopy in the future. Conclusions: Our results show that laparoscopic practice steadily increases in frequency and that urologists are willing to substitute open surgery for laparoscopic surgery. The performance of laparoscopic surgery has become a goal for most urologists in Turkey to achieve in the near future.
Cutaneous changes in patients with chronic renal failure on hemodialysis
(Taylor & Francis Ltd, 2012) Onelmis, Husniye; Sener, Serpil; Sasmaz, Sezai; Ozer, Ali
Context: A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series. Objective: To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients. Materials and methods: The study comprised one hundred patients with CRF under regular HD as well as one hundred healthy control subjects of matched age and sex. Both groups were subjected to full history and thorough skin examination. Results: Numerous skin lesions (at least one in each patient) were detected in all patients examined. Of these patients, nail abnormalities were observed in 92%, xerosis in 87%, fungal infection in 68%, hyperpigmentation in 62%, pruritus in 51%, and paleness in 51%. The nail changes included absence of lunula (55%), half and half nail (51%), splinter hemorrhages (36%), subungual hyperkeratosis (34%), onychomycosis (31%), koilonychia (19%), and onycholysis (9%). Oral changes were oral candidiasis (50%), xerostomia (40%), angular cheilitis (27%), and ulcerative stomatitis (18%). Specific cutaneous findings such as acquired perforating dermatosis, pseudoporphyria cutanea tarda, calciphylaxis, calcinosis cutis, and nephrogenic fibrosing dermopathy were not detected in any of the patients. In our study, when the patients were evaluated on the relationship between xerosis and pruritus, pruritus was found to be significantly increased parallel to the increase in the severity of xerosis. Conclusions: Xerosis and pruritus are common problems in HD-dependent patients. The early recognition of cutaneous signs can relieve suffering and decrease morbidity.
Downstaging in patients with hepatocellular carcinoma: Is there real hope?
(2019) Ozer, Ali
Aim: The conventional criteria preclude many patients with hepatocelular carcinom (HCC) from liver transplantation (LT). Recent studies reported comparable results in downstaged patients. In present study, the outcomes of patients with HCC after LT was evaluated in regard to response to a uniform downstaging protocol.Materials and Methods: The data of 136 HCC patients who underwent LT between January 2012 and April 2018 were analysed. 82 patients who were with minimum follow-up of one year and/or who reached the end-point (recurrence and/or death) were enrolled to the study and were divided into two groups as downstaging group and initially within Milan group. We retrospectively collected and then compared the baseline characteristics, postoperative complications, survival rate, and tumor recurrence rate of patients.Results: One of the study group included 54 (45.7%) patients within Milan criteria initially and there were 28 (23.7%) patients in the downstaging group. The disease-free survival rates were 82.1% and 87.1% in downstaging group and initially witihin Milan group, respectively (p=0.368). The overall 3-year survival rates were 82.1% and 88.9% in downstaging group and intially within Milan group, respectively (p=0.402).Conclusion: The patients who were initially excluded according to the current conventional criteria had a chance for LT with comparable outcome according to both the overall survival and disease-free survival rates.Keywords: Hepatocelular carcinom; liver transplantation; downstaging.
The effect of spirituality and health perception on screening behavior of people with and without a family history of cancer
(Springer Heidelberg, 2024) Soylar, Pinar; Ozer, Ali
Aim This study explored the role of health perceptions and spirituality on cancer screening participation among people with and without cancer history in first degree relatives (FDRs). Subject and methods A cross-sectional study was conducted in Elazig, Turkey, with 150 individuals (75 individuals without a family history of cancer and 75 individuals with a family history of cancer). Spirituality and health perception of participants were measured using the Perception of Health Scale and Spirituality Scale at Firat University Hospital. Univariate analysis (independent t-test/chi-square test) was applied first to identify the candidate independent variables. Then, multivariate logistic regression was used to examine the association between independent variables and participation in cancer screenings. Results People with cancer history in FDRs participated in more cancer screening such as mammography and colonoscopy than those without FDRs (p = 0.002 and p = 0.001, respectively). People with cancer history in FDRs participated have a better health perception than without FDRs (p = 0.001). Women (OR 3.694; 95% CI, 1.207-11.301; p = 0.022), health perception (OR 1.480; 95% CI, 1.290-1.697; p = 0.001), and spirituality (OR 1.074; 95% CI, 1.028-1.122; p = 0.001), were positively associated with the likelihood of participating in cancer screening. Conclusion Our study emphasized that spirituality and health perception promote the participation in cancer screening. Future studies with large sample size are suggested to examine cancer screening behaviors for Turkish at-risk populations due to family history.
The Effects of Depression and Impulsivity on Obesity and Binge Eating Disorder
(Kure Iletisim Grubu A S, 2015) Annagur, Bilge Burcak; Orhan, Ozlem; Ozer, Ali; Yalcin, Nur; Tamarn, Lut
Objective: The aim of study was to evaluate depression and impulsivity in obese people with binge eating disorder (BED). Method: The study included 149 obese study participants who were compared to 151 non-obese healthy controls. They were assessed with the Structured Clinical Interview (SCID-I), Eating Attitudes Test (EAT), Beck Depression Inventory (BDI), and Barratt Impulsiveness Scale-11 (BIS-11). Results: The prevalence of BED was 47.6% in the obese study participants. Obesity with BED was more common in female participants. Depressive disorder was detected in 41.2% of the obese subjects. There was no significant difference between BED (+) and BED (-) groups with respect to depressive disorder (p>0.05). The cognitive impulsivity and non-planning activity scores of the depressive group were significantly higher than for the participants without depression (p<0.05). The cognitive impulsivity scores of depressive obese participants were significantly higher than for obese participants without depression (p<0.05). Conclusion: Obesity appears to be associated with depression rather than impulsivity. Impulsivity was found in obese people with binge-eating specifically. This study suggests that depression and/or binge eating may be mediating factors for the outcome of obesity.
Epidemiology of Cyclospora Species in Humans in Malatya Province in Turkey
(Kowsar Publ, 2015) Karaman, Ulku; Daldal, Nilgun; Ozer, Ali; Enginyurt, Ozgur; Erturk, Omer
Background: Cyclospora species are rare among other Coccidia parasites and can cause recurrent gastroenteritis. Cyclospora spp. can infect reptiles, insects, rodents, and mammals. Objectives: The present study aimed to determine the epidemiology of Cyclospora spp. in Malatya province and its neighboring provinces. Patients and Methods: Totally, 2281 stool samples taken from patients with digestive system complaints who referred to the polyclinics affiliated with Inonu University, Faculty of Medicine in Malatya Province and its neighboring provinces, in 2006, and whose stool specimens were submitted to the parasitology department were examined. A questionnaire was developed to determine the epidemiology of Cyclospora spp. in the patients as the dependent variable of the study. All the participants signed an informed written consent. The samples were coated with Entellan T after staining via acid-fast staining and were examined on an immersion microscope objective. The data are presented as mean, standard deviation, or number/percentage. The chi-square test was used for the statistical analyses. Statistically, a P value < 0.05 was accepted as meaningful. Results: The stool samples were examined via direct microscopic examination and acid-fast staining. Positivity was determined in 129 (5.7%) cases. In the overall assessment of the patients with respect to general body itching, rectal itching, allergy, immunosuppression plus cancer, shortness of breath, ulcerative colitis, diarrhea, abdominal pain, salivation, constipation, nausea, vomiting, growth retardation, and anemia, there was no significant relationship. However, in the statistical evaluations among the positive cases, the difference was found to be significant. Conclusions: The study was conducted in Malatya Province, but patients from the neighboring provinces were also included in the evaluation during the study. Of all the positive cases, 5.6% were those from Malatya Province and its surrounding areas. Additionally, Cyclospora spp. were observed among the patients referring to the polyclinics with digestive system complaints in 8.1% of those from the Adiyaman province and in 6.9% of those from the Kahramanmaras region. The incidence of Cyclospora cayetanensis may be higher in these regions if an epidemiological study is performed. Consequently, we suggest that Cyclospora spp. be investigated in digestive system disorders, especially in immunosuppressed patients.
Evaluation of Depression, Temperament and Character Profiles in Female Patients with Fibromyalgia Syndrome
(Aves, 2011) Altunoren, Ozlem; Orhan, Fatma Ozlem; Nacitarhan, Vedat; Ozer, Ali; Karaaslan, Mehmet Fatih; Altunoren, Orcun
Objective: Fibromyalgia syndrome (FMS) is a musculoskeletal disorder characterized by diffuse body pain and is also regarded as a psychosomatic disorder. FMS is most commonly associated with depression among the psychological disorders. It is known that personality plays an important role in the etiology of psychosomatic disorders. In this study, we analyzed the temperament characteristics of FMS patients and healthy control group and, using data obtained from both groups, investigated whether these traits were associated with clinical features and depressive states in FMS patients. Methods: Fifty-one FMS patients and 51 healthy women were included in the study. Both groups were evaluated according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (text revision) (DSM-IV-TR). The Temperament and Character Inventory (TCI), the Hamilton Depression Rating Scale (HAM-D), the Fibromyalgia Impact Questionnaire (FIQ), and the Visual Analogue Scale (VAS) were applied to both groups. Results: According to DSM-IV-TR, 76.5% of FMS patients were diagnosed with psychiatric disorder. FMS patients had higher harm avoidance scores and lower self-directedness and persistence scores than healthy controls. Harm avoidance scores were found higher and self-directedness scores were found lower when the total corrected increment (TCI) points were used, but cooperation scores increased. HAM-D scores correlated positively with harm avoidance scores, but negatively with both self-directedness and cooperation scores. Conclusion: Depressive symptoms and personality features are related to the duration and severity of FMS, and therefore, should be further evaluated by physicians when planning the treatment and follow-up in FMS patients. (Archives of Neuropsychiatry 2011; 48: 31-8)
Evaluation of diagnostic performance of new antigen-based enzyme immune assay for diagnosis of Hepatitis C virus (HCV) infections
(Academic Journals, 2012) Kooglu, Mehmet; Ak, Sibel; Ak, Muharrem; Yakupogullari, Yusuf; Ozer, Ali
Laboratory diagnosis of Hepatitis C virus (HCV) is sometimes problematic. A novel immune enzyme assay (HCV-Core Antigen, Abbott Laboratories/Germany) has been recently licensed for detection of HCV antigen in human serum. In this study, we aimed to evaluate diagnostic performance of this new test in comparison with the HCV-RNA quantification and anti-HCV antibody (anti-HCV-Ab) analyses. A total of 152 serum samples of which 112 anti-HCV-Ab positive (range 1.08 to 386.54 s/co) and 40 anti-HCV-Ab negative (<1 s/co) were analyzed with HCV-RNA and HCV-Ag tests. According to HCV-RNA detection, sensitivity and specificity of HCV-Ag test was measured as 96.9 and 100%, respectively and of anti-HCV-Ab were measured as 100 and 60%, orderly. An excellent positive predictive value for HCV-Ag test was detected as 100%, whereas 28.5% for anti-HCV-Ab test. Pearson correlation analysis showed that there was a statistically significant and strong relationship (p < 0.001, R: 0.773) between HCV-Ag and HCV-RNA quantification analysis. The correlation between the two tests showed an exponential trend (R-2: 0.949). These results suggest that HCV-Ag test may be a reliable assay for HCV antigen detection, which is also well-correlated with serum viral load. However, large studies, including different HCV genotypes and with extreme viral quantity, are required to assess analytic potency of this novel kit.
Evaluation of Nurses' Vaccine Hesitancy, Psychological Resilience, and Anxiety Levels During COVID-19 Pandemic
(Aves, 2023) Akbulut, Sami; Boz, Gulseda; Gokce, Ayse; Unsal, Selver; Saritas, Hasan; Kizilay, Erva; Ozer, Ali
Objective: This study aimed to evaluate the vaccine hesitancy, psychological resilience, and anxiety levels of nurses during the COVID-19 pandemic. Materials and Methods: This cross-sectional study was conducted with 676 nurses working at the survey time. Sociodemographic features, the status of hesitancy against the COVID-19 vaccine, the Coronavirus Anxiety Scale, and the Brief Resilience Scale were used in the questionnaire form to collect the data. Results: Most participants (68.6%; n = 464) stated they were hesitant about the COVID-19 vaccine. A significantly higher rate of hesitancy was detected in the age group of 20-39 years, those who did not have COVID-19 vaccine, and those who did not think the COVID-19 vaccine is protective (P < .05). It was determined that 6.8% (n = 46) of the nurses had COVID-19 anxiety. A significantly higher rate of anxiety was detected in the age group of 40 years and older, those working in the emergency department, and those working in the COVID-19 unit during the pandemic period (P < .05). The median Brief Resilience Scale score of nurses is 19(6). A negative, weak, and significant relationship was found between the Brief Resilience Scale and Coronavirus Anxiety Scale scores (P = .001). Conclusion: During the pandemic, higher rates of anxiety were detected in healthcare personnel and those working in COVID-19 units. It was also found that as the level of anxiety increased, the level of psychological resilience decreased. To reduce the anxiety level and strengthen the psychological resilience of nurses, the cornerstones of the health system, fast, effective, and curative interventions should be made.

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